Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes E2F8
  • Mouse genes E2f8
  • Rat genes E2f8
  • Zfish genes e2f8
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set E2f8

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	E2F8	IDA		Human	PMID:22903062
Molecular Function	GO:0003677	DNA binding	E2f8	IDA		Mouse	PMID:15722552
Molecular Function	GO:0003677	DNA binding	e2f8	IDA		Zfish	PMID:22903062
Molecular Function	GO:0003700	DNA-binding transcription factor activity	E2F8	IMP		Human	PMID:22903062
Molecular Function	GO:0003700	DNA-binding transcription factor activity	E2f8	IMP		Mouse	MGI:MGI:5449497|PMID:23064266
Molecular Function	GO:0003700	DNA-binding transcription factor activity	E2f8	IMP		Mouse	MGI:MGI:5449498|PMID:23064264
Molecular Function	GO:0003700	DNA-binding transcription factor activity	E2f8	IMP		Mouse	MGI:MGI:5319718|PMID:22516201
Molecular Function	GO:0003700	DNA-binding transcription factor activity	e2f8	IMP		Zfish	PMID:22903062|ZFIN:ZDB-PUB-120822-27
Molecular Function	GO:0001217	DNA-binding transcription repressor activity	E2f8	IMP		Mouse	MGI:MGI:5319718|PMID:22516201
Molecular Function	GO:0001217	DNA-binding transcription repressor activity	E2f8	IMP		Mouse	MGI:MGI:5449498|PMID:23064264
Molecular Function	GO:0001217	DNA-binding transcription repressor activity	E2f8	IMP		Mouse	MGI:MGI:5449497|PMID:23064266
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	E2F8	IDA		Human	PMID:16179649
Molecular Function	GO:0042802	identical protein binding	E2f8	IPI	PR:Q58FA4	Mouse	PMID:15722552
Molecular Function	GO:0005515	protein binding	E2F8	IPI	UniProtKB:Q96AV8	Human	PMID:18202719
Molecular Function	GO:0005515	protein binding	E2F8	IPI	UniProtKB:Q12800	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	E2F8	IPI	UniProtKB:Q13643	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	E2F8	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	E2F8	IPI	UniProtKB:Q9UNE7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	E2F8	IPI	UniProtKB:O14645	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	E2F8	IPI	UniProtKB:O14901	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	E2F8	IPI	UniProtKB:P01112	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	E2F8	IPI	UniProtKB:P06396	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	E2F8	IPI	UniProtKB:P07550	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	E2F8	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	E2F8	IPI	UniProtKB:P37840	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	E2F8	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	E2F8	IPI	UniProtKB:P46379-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	E2F8	IPI	UniProtKB:P55212	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	E2F8	IPI	UniProtKB:Q14957	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	E2F8	IPI	UniProtKB:Q7Z412	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	E2F8	IPI	UniProtKB:Q92870-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	E2F8	IPI	UniProtKB:Q9UMX0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	E2F8	IPI	UniProtKB:Q9Y649	Human	PMID:32814053
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	E2F8	IDA		Human	PMID:16179649
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	E2F8	IDA		Human	PMID:28473536
Cellular Component	GO:0005829	cytosol	E2F8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005730	nucleolus	E2F8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	E2F8	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	E2f8	IDA		Mouse	PMID:15722552
Biological Process	GO:0033301	cell cycle comprising mitosis without cytokinesis	E2f8	IMP		Mouse	MGI:MGI:5449497|PMID:23064266
Biological Process	GO:0060718	chorionic trophoblast cell differentiation	E2f8	IMP		Mouse	MGI:MGI:5319718|PMID:22516201
Biological Process	GO:0048144	fibroblast proliferation	E2f8	IDA		Mouse	PMID:15722552
Biological Process	GO:0070365	hepatocyte differentiation	E2f8	IMP		Mouse	MGI:MGI:5449497|PMID:23064266
Biological Process	GO:0070365	hepatocyte differentiation	E2f8	IMP		Mouse	MGI:MGI:5449498|PMID:23064264
Biological Process	GO:0001946	lymphangiogenesis	e2f8	IGI	ZFIN:ZDB-MRPHLNO-121116-1,ZFIN:ZDB-MRPHLNO-121116-2	Zfish	PMID:24069224
Biological Process	GO:0001946	lymphangiogenesis	e2f8	IGI	ZFIN:ZDB-MRPHLNO-090507-1,ZFIN:ZDB-MRPHLNO-121116-1,ZFIN:ZDB-MRPHLNO-121116-2	Zfish	PMID:24069224
Biological Process	GO:0001946	lymphangiogenesis	e2f8	IGI	ZFIN:ZDB-MRPHLNO-100205-5,ZFIN:ZDB-MRPHLNO-121116-1,ZFIN:ZDB-MRPHLNO-121116-2	Zfish	PMID:24069224
Biological Process	GO:0008045	motor neuron axon guidance	e2f8	IGI	ZFIN:ZDB-GENE-030131-3527	Zfish	PMID:26681691
Biological Process	GO:0008045	motor neuron axon guidance	e2f8	IGI	ZFIN:ZDB-GENE-030131-3527,ZFIN:ZDB-GENE-030519-2	Zfish	PMID:26681691
Biological Process	GO:0032466	negative regulation of cytokinesis	E2f8	IMP		Mouse	MGI:MGI:5449497|PMID:23064266
Biological Process	GO:0032466	negative regulation of cytokinesis	E2f8	IMP		Mouse	MGI:MGI:5449498|PMID:23064264
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	e2f8	IGI	ZFIN:ZDB-GENE-030131-3527	Zfish	PMID:26681691
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	E2F8	IDA		Human	PMID:16179649
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	E2f8	IMP		Mouse	MGI:MGI:5449497|PMID:23064266
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	E2f8	IMP		Mouse	MGI:MGI:5319718|PMID:22516201
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	E2f8	IMP		Mouse	MGI:MGI:5449498|PMID:23064264
Biological Process	GO:0001890	placenta development	E2f8	IMP		Mouse	MGI:MGI:5319718|PMID:22516201
Biological Process	GO:0032877	positive regulation of DNA endoreduplication	E2f8	IMP		Mouse	MGI:MGI:5449497|PMID:23064266
Biological Process	GO:0032877	positive regulation of DNA endoreduplication	E2f8	IMP		Mouse	MGI:MGI:5449498|PMID:23064264
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	E2F8	IMP		Human	PMID:22903062
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	e2f8	IMP		Zfish	PMID:22903062|ZFIN:ZDB-PUB-120822-27
Biological Process	GO:0002040	sprouting angiogenesis	E2F8	IMP		Human	PMID:22903062
Biological Process	GO:0002040	sprouting angiogenesis	E2f8	IMP		Mouse	MGI:MGI:5447251|PMID:22903062
Biological Process	GO:0002040	sprouting angiogenesis	e2f8	IMP		Zfish	PMID:22903062|ZFIN:ZDB-PUB-120822-27
Biological Process	GO:0002040	sprouting angiogenesis	e2f8	IGI	ZFIN:ZDB-MRPHLNO-121116-1,ZFIN:ZDB-MRPHLNO-121116-2	Zfish	PMID:24069224
Biological Process	GO:0002040	sprouting angiogenesis	e2f8	IGI	ZFIN:ZDB-MRPHLNO-090507-1,ZFIN:ZDB-MRPHLNO-121116-1,ZFIN:ZDB-MRPHLNO-121116-2	Zfish	PMID:24069224
Biological Process	GO:0002040	sprouting angiogenesis	e2f8	IGI	ZFIN:ZDB-MRPHLNO-100205-5,ZFIN:ZDB-MRPHLNO-121116-1,ZFIN:ZDB-MRPHLNO-121116-2	Zfish	PMID:24069224
Biological Process	GO:0002040	sprouting angiogenesis	e2f8	IGI	ZFIN:ZDB-MRPHLNO-121116-1,ZFIN:ZDB-MRPHLNO-121116-2	Zfish	PMID:22903062
Biological Process	GO:0002040	sprouting angiogenesis	e2f8	IGI	ZFIN:ZDB-MRPHLNO-050513-12,ZFIN:ZDB-MRPHLNO-121116-1,ZFIN:ZDB-MRPHLNO-121116-2	Zfish	PMID:22903062
Biological Process	GO:0060707	trophoblast giant cell differentiation	E2f8	IMP		Mouse	MGI:MGI:5449497|PMID:23064266

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern