Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes E4F1
  • Mouse genes E4f1
  • Rat genes E4f1
  • Zfish genes e4f1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set E4f1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0035497	cAMP response element binding	E4F1	IDA		Human	PMID:14645522
Molecular Function	GO:0003677	DNA binding	E4f1	IDA		Mouse	PMID:15226446
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	E4F1	IDA		Human	PMID:10869426
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	E4F1	IDA		Human	PMID:9121437
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	E4F1	IDA		Human	PMID:16652157
Molecular Function	GO:0005515	protein binding	E4F1	IPI	UniProtKB:Q08999	Human	PMID:10869426
Molecular Function	GO:0005515	protein binding	E4F1	IPI	UniProtKB:Q13547	Human	PMID:12730668
Molecular Function	GO:0005515	protein binding	E4F1	IPI	UniProtKB:Q64770	Human	PMID:12730668
Molecular Function	GO:0005515	protein binding	E4F1	IPI	UniProtKB:Q9NS23-2	Human	PMID:14729613
Molecular Function	GO:0005515	protein binding	E4F1	IPI	UniProtKB:P39687	Human	PMID:17557114
Molecular Function	GO:0005515	protein binding	E4F1	IPI	UniProtKB:A4VCF7	Human	PMID:21666599
Molecular Function	GO:0005515	protein binding	E4F1	IPI	UniProtKB:Q6IT96	Human	PMID:21666599
Molecular Function	GO:0005515	protein binding	E4F1	IPI	UniProtKB:Q9YHE8	Human	PMID:21666599
Molecular Function	GO:0005515	protein binding	E4f1	IPI	UniProtKB:O35381	Mouse	MGI:MGI:3790451|PMID:17557114
Molecular Function	GO:0005515	protein binding	E4f1	IPI	PR:P25233	Mouse	PMID:12198120
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	E4F1	IDA		Human	PMID:2169022
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	E4F1	IPI	UniProtKB:P52926	Human	PMID:14645522
Cellular Component	GO:0016604	nuclear body	E4F1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	E4F1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	E4f1	IDA		Mouse	PMID:15226446
Cellular Component	GO:0005819	spindle	E4f1	IDA		Mouse	PMID:15226446
Biological Process	GO:0006260	DNA replication	E4f1	IMP	MGI:MGI:3050154	Mouse	PMID:15226446
Biological Process	GO:0009790	embryo development	E4f1	IMP	MGI:MGI:3050154	Mouse	PMID:15226446
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	E4F1	IDA		Human	PMID:14645522
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	E4F1	IDA		Human	PMID:16652157
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	E4F1	IDA		Human	PMID:9121437
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	E4f1	IDA		Mouse	PMID:12198120
Biological Process	GO:0010564	regulation of cell cycle process	E4F1	IDA		Human	PMID:14645522
Biological Process	GO:0010564	regulation of cell cycle process	E4f1	IDA		Mouse	MGI:MGI:5284804|PMID:14645522
Biological Process	GO:0009794	regulation of mitotic cell cycle, embryonic	E4f1	IMP	MGI:MGI:3050154	Mouse	PMID:15226446

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern