Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ECE1
  • Mouse genes Ece1
  • Rat genes Ece1
  • Zfish genes ece1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ece1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	ECE1	IDA		Human	PMID:18039931
Molecular Function	GO:0004175	endopeptidase activity	ECE1	IDA		Human	PMID:7805846
Molecular Function	GO:0042802	identical protein binding	Ece1	IMP		Rat	PMID:8645169|RGD:7244169
Molecular Function	GO:0005515	protein binding	ECE1	IPI	UniProtKB:P49760	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ECE1	IPI	UniProtKB:P60370	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ECE1	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ECE1	IPI	UniProtKB:P49760	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ECE1	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ECE1	IPI	UniProtKB:Q8IUG1	Human	PMID:32296183
Molecular Function	GO:0042803	protein homodimerization activity	ECE1	IPI	UniProtKB:P42892	Human	PMID:7805846
Molecular Function	GO:0008270	zinc ion binding	ECE1	IDA		Human	PMID:18992253
Cellular Component	GO:0031410	cytoplasmic vesicle	Ece1	IDA		Rat	PMID:22881710|RGD:7243859
Cellular Component	GO:0005769	early endosome	Ece1	IDA		Rat	PMID:22881710|RGD:7243859
Cellular Component	GO:0005768	endosome	ECE1	IDA		Human	PMID:18039931
Cellular Component	GO:0009897	external side of plasma membrane	ECE1	IDA		Human	PMID:9449382
Cellular Component	GO:0009897	external side of plasma membrane	ECE1	IDA		Human	PMID:9710124
Cellular Component	GO:0009897	external side of plasma membrane	Ece1	IDA		Rat	PMID:9449382|RGD:8553464
Cellular Component	GO:0070062	extracellular exosome	ECE1	HDA		Human	PMID:19056867
Cellular Component	GO:0005765	lysosomal membrane	ECE1	HDA		Human	PMID:17897319
Cellular Component	GO:0016020	membrane	ECE1	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	ECE1	IDA		Human	PMID:7805846
Cellular Component	GO:0016020	membrane	Ece1	IDA		Rat	PMID:8034569|RGD:728596
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ECE1	IDA		Human	PMID:9710124
Cellular Component	GO:0005886	plasma membrane	Ece1	IDA		Rat	PMID:8645169|RGD:7244169
Cellular Component	GO:0030141	secretory granule	Ece1	IDA		Rat	PMID:11813889|RGD:728806
Cellular Component	GO:0031982	vesicle	Ece1	IDA		Rat	PMID:9449382|RGD:8553464
Cellular Component	GO:0033093	Weibel-Palade body	ECE1	IDA		Human	PMID:9710124
Biological Process	GO:0006915	apoptotic process	Ece1	IMP		Rat	PMID:15733912|RGD:1581735
Biological Process	GO:0060385	axonogenesis involved in innervation	Ece1	IMP	MGI:MGI:2158947	Mouse	PMID:30735130
Biological Process	GO:0097746	blood vessel diameter maintenance	Ece1	IMP		Rat	PMID:22881710|RGD:7243859
Biological Process	GO:0010815	bradykinin catabolic process	ECE1	IDA		Human	PMID:18039931
Biological Process	GO:0010816	calcitonin catabolic process	ECE1	IDA		Human	PMID:18039931
Biological Process	GO:0043583	ear development	ECE1	IMP		Human	PMID:9915973
Biological Process	GO:0042733	embryonic digit morphogenesis	ECE1	IMP		Human	PMID:9915973
Biological Process	GO:0035050	embryonic heart tube development	Ece1	IMP	MGI:MGI:2158947	Mouse	PMID:30735130
Biological Process	GO:0035050	embryonic heart tube development	Ece1	IMP	MGI:MGI:2687362	Mouse	PMID:30735130
Biological Process	GO:0035050	embryonic heart tube development	Ece1	IMP	MGI:MGI:1857637	Mouse	PMID:30735130
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	ece1	IMP	ZFIN:ZDB-MRPHLNO-170512-2	Zfish	PMID:28109039
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	ece1	IMP	ZFIN:ZDB-MRPHLNO-170512-1	Zfish	PMID:28109039
Biological Process	GO:0034959	endothelin maturation	ECE1	IDA		Human	PMID:7805846
Biological Process	GO:0010467	gene expression	Ece1	IMP	MGI:MGI:2158947	Mouse	PMID:30735130
Biological Process	GO:0007507	heart development	ECE1	IMP		Human	PMID:9915973
Biological Process	GO:0042447	hormone catabolic process	ECE1	IDA		Human	PMID:7864876
Biological Process	GO:0031175	neuron projection development	Ece1	IMP	MGI:MGI:2158947	Mouse	PMID:24875861
Biological Process	GO:0016486	peptide hormone processing	ECE1	IDA		Human	PMID:7864876
Biological Process	GO:0060037	pharyngeal system development	Ece1	IMP	MGI:MGI:2158947	Mouse	PMID:12950083
Biological Process	GO:0043950	positive regulation of cAMP-mediated signaling	Ece1	IMP		Rat	PMID:22881710|RGD:7243859
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	Ece1	IMP		Rat	PMID:20099522|RGD:7243873
Biological Process	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	Ece1	IMP		Rat	PMID:15733912|RGD:1581735
Biological Process	GO:0001921	positive regulation of receptor recycling	ECE1	IMP		Human	PMID:18039931
Biological Process	GO:0001921	positive regulation of receptor recycling	Ece1	IMP		Rat	PMID:21878523|RGD:7243869
Biological Process	GO:0016485	protein processing	ECE1	IDA		Human	PMID:7805846
Biological Process	GO:0016485	protein processing	Ece1	IDA		Rat	PMID:8034569|RGD:728596
Biological Process	GO:0008217	regulation of blood pressure	Ece1	IMP		Rat	PMID:19596829|RGD:7243876
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	Ece1	IMP		Rat	PMID:21878523|RGD:7243869
Biological Process	GO:0046686	response to cadmium ion	Ece1	IEP		Rat	PMID:12189509|RGD:7244161
Biological Process	GO:0001666	response to hypoxia	Ece1	IDA		Rat	PMID:11813889|RGD:728806
Biological Process	GO:0035994	response to muscle stretch	Ece1	IEP		Rat	PMID:16410403|RGD:7243951
Biological Process	GO:0009410	response to xenobiotic stimulus	Ece1	IEP		Rat	PMID:11145282|RGD:7244163
Biological Process	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	Ece1	IMP	MGI:MGI:1857637	Mouse	PMID:30735130
Biological Process	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	Ece1	IMP	MGI:MGI:2687362	Mouse	PMID:30735130
Biological Process	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	Ece1	IMP	MGI:MGI:2158947	Mouse	PMID:30735130
Biological Process	GO:0010814	substance P catabolic process	ECE1	IDA		Human	PMID:18039931
Biological Process	GO:0097492	sympathetic neuron axon guidance	Ece1	IMP	MGI:MGI:1857637	Mouse	PMID:30735130
Biological Process	GO:0097492	sympathetic neuron axon guidance	Ece1	IMP	MGI:MGI:3718323	Mouse	PMID:30735130
Biological Process	GO:0097492	sympathetic neuron axon guidance	Ece1	IMP	MGI:MGI:2158947	Mouse	PMID:30735130
Biological Process	GO:0097492	sympathetic neuron axon guidance	Ece1	IMP	MGI:MGI:2687362	Mouse	PMID:30735130

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern