Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EDEM1
  • Mouse genes Edem1
  • Rat genes Edem1
  • Zfish genes edem1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Edem1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	EDEM1	IMP		Human	PMID:25092655
Molecular Function	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	Edem1	IMP		Mouse	MGI:MGI:5645205|PMID:20065073
Molecular Function	GO:0051787	misfolded protein binding	EDEM1	IDA		Human	PMID:19524542
Molecular Function	GO:0051787	misfolded protein binding	EDEM1	IMP		Human	PMID:23233672
Molecular Function	GO:0005515	protein binding	EDEM1	IPI	UniProtKB:Q96Q80	Human	PMID:16449189
Molecular Function	GO:0005515	protein binding	EDEM1	IPI	UniProtKB:Q9GZP9	Human	PMID:16449189
Molecular Function	GO:0005515	protein binding	EDEM1	IPI	UniProtKB:Q9UBV2	Human	PMID:19524542
Molecular Function	GO:0005515	protein binding	EDEM1	IPI	UniProtKB:P08100	Human	PMID:19934218
Molecular Function	GO:0005515	protein binding	Edem1	IPI	UniProtKB:Q9DC23	Mouse	MGI:MGI:4947480|PMID:21329881
Molecular Function	GO:0005515	protein binding	Edem1	IPI	UniProtKB:P02879	Mouse	MGI:MGI:5563002|PMID:24200403
Cellular Component	GO:0016235	aggresome	EDEM1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	EDEM1	IMP		Human	PMID:21062743
Cellular Component	GO:0005783	endoplasmic reticulum	EDEM1	IDA		Human	PMID:24200403
Cellular Component	GO:0005789	endoplasmic reticulum membrane	Edem1	IDA		Mouse	PMID:11375934
Cellular Component	GO:0044322	endoplasmic reticulum quality control compartment	EDEM1	IDA		Human	PMID:23233672
Biological Process	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	EDEM1	IMP		Human	PMID:25092655
Biological Process	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol	EDEM1	IGI	UniProtKB:Q9BV94	Human	PMID:24200403
Biological Process	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol	EDEM1	IMP		Human	PMID:24200403
Biological Process	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol	Edem1	IDA		Mouse	MGI:MGI:5563002|PMID:24200403
Biological Process	GO:0045047	protein targeting to ER	EDEM1	IMP		Human	PMID:23233672
Biological Process	GO:0036510	trimming of terminal mannose on C branch	Edem1	IMP		Mouse	MGI:MGI:5645205|PMID:20065073
Biological Process	GO:0030433	ubiquitin-dependent ERAD pathway	Edem1	IDA		Mouse	PMID:11375934
Biological Process	GO:0097466	ubiquitin-dependent glycoprotein ERAD pathway	EDEM1	IMP		Human	PMID:21062743
Biological Process	GO:0097466	ubiquitin-dependent glycoprotein ERAD pathway	EDEM1	IMP		Human	PMID:25092655

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern