Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EDEM2
  • Mouse genes Edem2
  • Rat genes Edem2
  • Zfish genes edem2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Edem2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	EDEM2	IMP		Human	PMID:25092655
Molecular Function	GO:0005515	protein binding	Edem2	IPI	UniProtKB:P02879	Mouse	MGI:MGI:5563002|PMID:24200403
Cellular Component	GO:0005783	endoplasmic reticulum	EDEM2	IDA		Human	PMID:15537790
Cellular Component	GO:0005783	endoplasmic reticulum	EDEM2	IDA		Human	PMID:24200403
Biological Process	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	EDEM2	IMP		Human	PMID:25092655
Biological Process	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol	EDEM2	IGI	UniProtKB:Q92611	Human	PMID:24200403
Biological Process	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol	EDEM2	IMP		Human	PMID:24200403
Biological Process	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol	Edem2	IDA		Mouse	MGI:MGI:5563002|PMID:24200403
Biological Process	GO:0036509	trimming of terminal mannose on B branch	EDEM2	IMP		Human	PMID:25092655
Biological Process	GO:0097466	ubiquitin-dependent glycoprotein ERAD pathway	EDEM2	IMP		Human	PMID:15537790

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern