Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EDN1
  • Mouse genes Edn1
  • Rat genes Edn1
  • Zfish genes edn1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Edn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005125	cytokine activity	EDN1	IDA		Human	PMID:19767294
Molecular Function	GO:0031707	endothelin A receptor binding	EDN1	IDA		Human	PMID:10770212
Molecular Function	GO:0031707	endothelin A receptor binding	Edn1	IPI	PR:Q61614	Mouse	PMID:9449664
Molecular Function	GO:0031707	endothelin A receptor binding	Edn1	IMP		Rat	PMID:15655307|RGD:1580292
Molecular Function	GO:0031708	endothelin B receptor binding	EDN1	IDA		Human	PMID:10770212
Molecular Function	GO:0031708	endothelin B receptor binding	EDN1	IPI	UniProtKB:P24530	Human	PMID:1713452
Molecular Function	GO:0031708	endothelin B receptor binding	Edn1	IMP		Rat	PMID:15655307|RGD:1580292
Molecular Function	GO:0005179	hormone activity	EDN1	IDA		Human	PMID:10770212
Molecular Function	GO:0005179	hormone activity	EDN1	IDA		Human	PMID:2649896
Molecular Function	GO:0005515	protein binding	EDN1	IPI	UniProtKB:B0L3A2	Human	PMID:17446437
Molecular Function	GO:0005515	protein binding	EDN1	IPI	UniProtKB:P24530	Human	PMID:23597562
Molecular Function	GO:0005515	protein binding	EDN1	IPI	UniProtKB:P25101	Human	PMID:23597562
Molecular Function	GO:0005515	protein binding	Edn1	IPI	PR:P48302	Mouse	PMID:12441350
Molecular Function	GO:0005102	signaling receptor binding	Edn1	IDA		Mouse	PMID:2542249
Molecular Function	GO:0005102	signaling receptor binding	Edn1	IDA		Mouse	PMID:8680799
Cellular Component	GO:0045178	basal part of cell	Edn1	IDA		Rat	PMID:11174056|RGD:8662388
Cellular Component	GO:0005737	cytoplasm	EDN1	IDA		Human	PMID:12379507
Cellular Component	GO:0005615	extracellular space	EDN1	IDA		Human	PMID:10770212
Cellular Component	GO:0005615	extracellular space	EDN1	IDA		Human	PMID:15691296
Cellular Component	GO:0005615	extracellular space	EDN1	IDA		Human	PMID:16820593
Cellular Component	GO:0005615	extracellular space	Edn1	IDA		Mouse	PMID:15314687
Cellular Component	GO:0005615	extracellular space	Edn1	IDA		Rat	PMID:15738350|RGD:1625066
Cellular Component	GO:0048237	rough endoplasmic reticulum lumen	Edn1	IDA		Rat	PMID:10903535|RGD:8662311
Cellular Component	GO:0033093	Weibel-Palade body	Edn1	IDA		Rat	PMID:10903535|RGD:8662311
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	Edn1	IDA		Mouse	PMID:2542249
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	Edn1	IGI	MGI:MGI:88121	Mouse	PMID:15632412
Biological Process	GO:0048899	anterior lateral line development	edn1	IMP	ZFIN:ZDB-MRPHLNO-060317-3	Zfish	PMID:20171200
Biological Process	GO:0048901	anterior lateral line neuromast development	edn1	IMP	ZFIN:ZDB-MRPHLNO-060317-3	Zfish	PMID:20171200
Biological Process	GO:0014824	artery smooth muscle contraction	EDN1	IDA		Human	PMID:8982507
Biological Process	GO:0014824	artery smooth muscle contraction	Edn1	IDA		Rat	PMID:7586220|RGD:8662314
Biological Process	GO:0048675	axon extension	Edn1	IDA		Mouse	PMID:18401410
Biological Process	GO:0060385	axonogenesis involved in innervation	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:30735130
Biological Process	GO:0060385	axonogenesis involved in innervation	Edn1	IMP		Mouse	PMID:24875861
Biological Process	GO:0048514	blood vessel morphogenesis	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:7615798
Biological Process	GO:0007589	body fluid secretion	Edn1	IMP	MGI:MGI:3044563,MGI:MGI:3054057	Mouse	PMID:15314687
Biological Process	GO:0060349	bone morphogenesis	edn1	IMP	ZFIN:ZDB-MRPHLNO-060317-3	Zfish	PMID:20171200
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:23933587
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:7615798
Biological Process	GO:0070588	calcium ion transmembrane transport	Edn1	IDA		Mouse	PMID:24722437
Biological Process	GO:0019722	calcium-mediated signaling	EDN1	IDA		Human	PMID:10770212
Biological Process	GO:0019722	calcium-mediated signaling	EDN1	IDA		Human	PMID:1917960
Biological Process	GO:0060070	canonical Wnt signaling pathway	Edn1	IDA		Mouse	PMID:24722437
Biological Process	GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis	Edn1	IDA		Mouse	PMID:31219639
Biological Process	GO:0051216	cartilage development	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:8152482
Biological Process	GO:0051216	cartilage development	edn1	IMP	ZFIN:ZDB-GENO-980202-1068	Zfish	PMID:16678149
Biological Process	GO:0051216	cartilage development	edn1	IMP	ZFIN:ZDB-MRPHLNO-060317-3	Zfish	PMID:16678149
Biological Process	GO:0051216	cartilage development	edn1	IGI	ZFIN:ZDB-GENO-980202-1065,ZFIN:ZDB-GENO-980202-1068	Zfish	PMID:16678149
Biological Process	GO:0051216	cartilage development	edn1	IMP	ZFIN:ZDB-MRPHLNO-060317-3	Zfish	PMID:16759393
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	edn1	IGI	ZFIN:ZDB-GENO-980202-1068,ZFIN:ZDB-MRPHLNO-041207-6	Zfish	PMID:20431122
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	edn1	IMP	ZFIN:ZDB-GENO-980202-1068	Zfish	PMID:20431122
Biological Process	GO:0060351	cartilage development involved in endochondral bone morphogenesis	edn1	IGI	ZFIN:ZDB-GENO-100727-7	Zfish	PMID:20431122
Biological Process	GO:0060536	cartilage morphogenesis	edn1	IMP	ZFIN:ZDB-GENO-980202-1068	Zfish	PMID:9007254
Biological Process	GO:0007166	cell surface receptor signaling pathway	EDN1	IDA		Human	PMID:1713452
Biological Process	GO:0007267	cell-cell signaling	EDN1	IDA		Human	PMID:12379507
Biological Process	GO:0071277	cellular response to calcium ion	Edn1	IEP		Rat	PMID:1852000|RGD:8662267
Biological Process	GO:0071398	cellular response to fatty acid	Edn1	IEP		Rat	PMID:9784597|RGD:8662270
Biological Process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	Edn1	IDA		Mouse	PMID:19111534
Biological Process	GO:0071385	cellular response to glucocorticoid stimulus	Edn1	IEP		Rat	PMID:9514952|RGD:8662272
Biological Process	GO:0044751	cellular response to human chorionic gonadotropin stimulus	Edn1	IDA		Mouse	PMID:19111534
Biological Process	GO:0070301	cellular response to hydrogen peroxide	EDN1	IDA		Human	PMID:30990108
Biological Process	GO:0071456	cellular response to hypoxia	Edn1	IEP		Rat	PMID:9551744|RGD:8662285
Biological Process	GO:0071347	cellular response to interleukin-1	Edn1	IEP		Rat	PMID:20512083|RGD:4144864
Biological Process	GO:0071373	cellular response to luteinizing hormone stimulus	Edn1	IDA		Mouse	PMID:19111534
Biological Process	GO:0071389	cellular response to mineralocorticoid stimulus	Edn1	IEP		Rat	PMID:19638349|RGD:8661802
Biological Process	GO:0071310	cellular response to organic substance	EDN1	IDA		Human	PMID:30990108
Biological Process	GO:0071310	cellular response to organic substance	Edn1	IMP	MGI:MGI:3692770	Mouse	PMID:30990108
Biological Process	GO:0071310	cellular response to organic substance	Edn1	IDA		Mouse	PMID:30990108
Biological Process	GO:0071310	cellular response to organic substance	Edn1	IMP		Mouse	PMID:30990108
Biological Process	GO:0071375	cellular response to peptide hormone stimulus	Edn1	IEP		Rat	PMID:18094363|RGD:2325639
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Edn1	IEP		Rat	PMID:8439651|RGD:8662306
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Edn1	IEP		Rat	PMID:20512083|RGD:4144864
Biological Process	GO:0071346	cellular response to type II interferon	Edn1	IEP		Rat	PMID:22301113|RGD:8662301
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Edn1	IEP		Rat	PMID:8129032|RGD:8662286
Biological Process	GO:1904888	cranial skeletal system development	edn1	IMP	ZFIN:ZDB-GENO-980202-1068	Zfish	PMID:27058748
Biological Process	GO:0009953	dorsal/ventral pattern formation	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:15110048
Biological Process	GO:0009953	dorsal/ventral pattern formation	edn1	IMP	ZFIN:ZDB-GENO-130816-8	Zfish	PMID:22031546
Biological Process	GO:0035050	embryonic heart tube development	Edn1	IMP	MGI:MGI:1857473	Mouse	PMID:31219639
Biological Process	GO:0035050	embryonic heart tube development	Edn1	IMP	MGI:MGI:2687362	Mouse	PMID:30735130
Biological Process	GO:0035050	embryonic heart tube development	Edn1	IMP	MGI:MGI:2158947	Mouse	PMID:30735130
Biological Process	GO:0035050	embryonic heart tube development	Edn1	IMP	MGI:MGI:2687362	Mouse	PMID:24875861
Biological Process	GO:0035050	embryonic heart tube development	Edn1	IMP	MGI:MGI:1857473	Mouse	PMID:24875861
Biological Process	GO:0035050	embryonic heart tube development	Edn1	IMP	MGI:MGI:2687362	Mouse	PMID:31219639
Biological Process	GO:0035050	embryonic heart tube development	Edn1	IMP		Mouse	PMID:24875861
Biological Process	GO:0035050	embryonic heart tube development	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:30735130
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	edn1	IMP	ZFIN:ZDB-GENO-150219-10,ZFIN:ZDB-GENO-150219-12	Zfish	PMID:23826316
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	edn1	IGI	ZFIN:ZDB-GENE-030131-9854	Zfish	PMID:24915580
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	edn1	IMP	ZFIN:ZDB-GENO-980202-1068	Zfish	PMID:21073867
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	edn1	IGI	ZFIN:ZDB-GENO-070209-215,ZFIN:ZDB-GENO-080226-1	Zfish	PMID:17239364
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	edn1	IMP	ZFIN:ZDB-GENO-980202-1068	Zfish	PMID:12588851
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	edn1	IMP	ZFIN:ZDB-GENO-980202-1068	Zfish	PMID:10934026
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	edn1	IMP	ZFIN:ZDB-MRPHLNO-060317-3	Zfish	PMID:28109039
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	edn1	IMP	ZFIN:ZDB-MRPHLNO-060317-3	Zfish	PMID:27880803
Biological Process	GO:0086100	endothelin receptor signaling pathway	EDN1	IMP		Human	PMID:19086031
Biological Process	GO:0086101	endothelin receptor signaling pathway involved in heart process	Edn1	IDA		Mouse	PMID:31219639
Biological Process	GO:0042045	epithelial fluid transport	Edn1	IDA		Rat	PMID:18948426|RGD:4892575
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Edn1	IDA		Mouse	PMID:20929948
Biological Process	GO:0060325	face morphogenesis	edn1	IMP	ZFIN:ZDB-GENO-980202-1068	Zfish	PMID:20431122
Biological Process	GO:0060325	face morphogenesis	edn1	IGI	ZFIN:ZDB-GENO-100727-7	Zfish	PMID:20431122
Biological Process	GO:0060325	face morphogenesis	edn1	IGI	ZFIN:ZDB-GENO-980202-1068,ZFIN:ZDB-MRPHLNO-041207-6	Zfish	PMID:20431122
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	EDN1	IDA		Human	PMID:17078114
Biological Process	GO:0010467	gene expression	Edn1	IMP	MGI:MGI:3044563	Mouse	PMID:20516397
Biological Process	GO:0010467	gene expression	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:30735130
Biological Process	GO:0010467	gene expression	Edn1	IDA		Mouse	PMID:24722437
Biological Process	GO:0010467	gene expression	Edn1	IDA		Mouse	PMID:20929948
Biological Process	GO:0007507	heart development	Edn1	IMP		Mouse	PMID:24875861
Biological Process	GO:0007507	heart development	Edn1	IMP	MGI:MGI:1857473	Mouse	PMID:24875861
Biological Process	GO:0007507	heart development	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:7615798
Biological Process	GO:0001821	histamine secretion	Edn1	IDA		Rat	PMID:18787779|RGD:4892576
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Edn1	IDA		Mouse	PMID:24722437
Biological Process	GO:0001701	in utero embryonic development	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:15327783
Biological Process	GO:0048016	inositol phosphate-mediated signaling	EDN1	IDA		Human	PMID:1917960
Biological Process	GO:0006874	intracellular calcium ion homeostasis	EDN1	IDA		Human	PMID:30990108
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Edn1	IDA		Mouse	PMID:30990108
Biological Process	GO:0035556	intracellular signal transduction	Edn1	IDA		Rat	PMID:12388423|RGD:727457
Biological Process	GO:0000165	MAPK cascade	Edn1	IMP		Mouse	PMID:19111534
Biological Process	GO:0000165	MAPK cascade	Edn1	IDA		Mouse	PMID:19111534
Biological Process	GO:0060137	maternal process involved in parturition	Edn1	IEP		Rat	PMID:18948426|RGD:4892575
Biological Process	GO:1903537	meiotic cell cycle process involved in oocyte maturation	Edn1	IDA		Mouse	PMID:19111534
Biological Process	GO:0051899	membrane depolarization	Edn1	IMP		Rat	PMID:15655307|RGD:1580292
Biological Process	GO:0042474	middle ear morphogenesis	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:8152482
Biological Process	GO:0007005	mitochondrion organization	Edn1	IDA		Mouse	PMID:27899487
Biological Process	GO:0010259	multicellular organism aging	Edn1	IEP		Rat	PMID:20522806|RGD:4144863
Biological Process	GO:0010629	negative regulation of gene expression	Edn1	IDA		Rat	PMID:28484848|RGD:13601996
Biological Process	GO:0046888	negative regulation of hormone secretion	Edn1	IDA		Rat	PMID:1533364|RGD:1581817
Biological Process	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process	EDN1	IDA		Human	PMID:16820593
Biological Process	GO:0051248	negative regulation of protein metabolic process	EDN1	IDA		Human	PMID:19767294
Biological Process	GO:0034392	negative regulation of smooth muscle cell apoptotic process	Edn1	IDA		Rat	PMID:16857764|RGD:4892596
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	EDN1	IDA		Human	PMID:19767294
Biological Process	GO:0014032	neural crest cell development	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:15327783
Biological Process	GO:0014032	neural crest cell development	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:9671575
Biological Process	GO:0014033	neural crest cell differentiation	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:23933587
Biological Process	GO:0014033	neural crest cell differentiation	edn1	IMP	ZFIN:ZDB-GENO-980202-1068	Zfish	PMID:21073867
Biological Process	GO:0014034	neural crest cell fate commitment	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:23933587
Biological Process	GO:0031175	neuron projection development	Edn1	IDA		Mouse	PMID:24875861
Biological Process	GO:0030185	nitric oxide transport	EDN1	IDA		Human	PMID:16820593
Biological Process	GO:0003357	noradrenergic neuron differentiation	Edn1	IMP	MGI:MGI:1857473	Mouse	PMID:24875861
Biological Process	GO:0003357	noradrenergic neuron differentiation	Edn1	IMP		Mouse	PMID:24875861
Biological Process	GO:0030072	peptide hormone secretion	EDN1	IDA		Human	PMID:10770212
Biological Process	GO:0061626	pharyngeal arch artery morphogenesis	Edn1	IMP	MGI:MGI:4867385	Mouse	PMID:23933587
Biological Process	GO:0061626	pharyngeal arch artery morphogenesis	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:23933587
Biological Process	GO:0061626	pharyngeal arch artery morphogenesis	Edn1	IMP	MGI:MGI:3773698	Mouse	PMID:23933587
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	EDN1	IDA		Human	PMID:17078114
Biological Process	GO:0031583	phospholipase D-activating G protein-coupled receptor signaling pathway	Edn1	IDA		Mouse	PMID:8978712
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	EDN1	IDA		Human	PMID:12847114
Biological Process	GO:2001259	positive regulation of cation channel activity	EDN1	IDA		Human	PMID:30990108
Biological Process	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	EDN1	IDA		Human	PMID:24117217
Biological Process	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	EDN1	IGI	RNAcentral:URS000006FDD4_9606,RNAcentral:URS000013D17D_9606	Human	PMID:24117217
Biological Process	GO:0030335	positive regulation of cell migration	EDN1	IDA		Human	PMID:9696419
Biological Process	GO:0008284	positive regulation of cell population proliferation	EDN1	IDA		Human	PMID:17078114
Biological Process	GO:0008284	positive regulation of cell population proliferation	EDN1	IDA		Human	PMID:1917960
Biological Process	GO:0008284	positive regulation of cell population proliferation	Edn1	IDA		Mouse	PMID:2542249
Biological Process	GO:0008284	positive regulation of cell population proliferation	Edn1	IDA		Rat	PMID:19628632|RGD:4892557
Biological Process	GO:0045793	positive regulation of cell size	EDN1	IDA		Human	PMID:12847114
Biological Process	GO:0070101	positive regulation of chemokine-mediated signaling pathway	EDN1	IDA		Human	PMID:17178876
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	EDN1	IDA		Human	PMID:1917960
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Edn1	IDA		Rat	PMID:18288637|RGD:4892583
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	Edn1	IDA		Mouse	PMID:2542249
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	EDN1	IDA		Human	PMID:24117217
Biological Process	GO:0010460	positive regulation of heart rate	EDN1	IDA		Human	PMID:2649896
Biological Process	GO:0046887	positive regulation of hormone secretion	EDN1	IDA		Human	PMID:10770212
Biological Process	GO:0043507	positive regulation of JUN kinase activity	EDN1	IDA		Human	PMID:12847114
Biological Process	GO:0043406	positive regulation of MAP kinase activity	EDN1	IDA		Human	PMID:10770212
Biological Process	GO:0043406	positive regulation of MAP kinase activity	EDN1	IDA		Human	PMID:12847114
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	EDN1	IDA		Human	PMID:10770212
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	Edn1	IDA		Rat	PMID:18787779|RGD:4892576
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	Edn1	IDA		Rat	PMID:28484848|RGD:13601996
Biological Process	GO:0042482	positive regulation of odontogenesis	Edn1	IDA		Rat	PMID:16843458|RGD:4892598
Biological Process	GO:0032308	positive regulation of prostaglandin secretion	Edn1	IDA		Rat	PMID:1324048|RGD:8662308
Biological Process	GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity	EDN1	IMP		Human	PMID:9492062
Biological Process	GO:0035815	positive regulation of renal sodium excretion	Edn1	IMP	MGI:MGI:3044563,MGI:MGI:3054057	Mouse	PMID:15314687
Biological Process	GO:0060298	positive regulation of sarcomere organization	EDN1	IMP		Human	PMID:12847114
Biological Process	GO:2000273	positive regulation of signaling receptor activity	EDN1	IDA		Human	PMID:17178876
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	EDN1	IDA		Human	PMID:10393673
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	Edn1	IDA		Mouse	PMID:8010105
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	Edn1	IDA		Rat	PMID:12396026|RGD:1581797
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	Edn1	IMP		Rat	PMID:8893723|RGD:8662282
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	EDN1	IDA		Human	PMID:24117217
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Edn1	IDA		Rat	PMID:18094364|RGD:8662300
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Edn1	IDA		Rat	PMID:8587476|RGD:8662397
Biological Process	GO:0035810	positive regulation of urine volume	Edn1	IGI	MGI:MGI:88121	Mouse	PMID:15632412
Biological Process	GO:0035810	positive regulation of urine volume	Edn1	IMP	MGI:MGI:3044563,MGI:MGI:3054057	Mouse	PMID:15632412
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	Edn1	IDA		Rat	PMID:28484848|RGD:13601996
Biological Process	GO:0001516	prostaglandin biosynthetic process	EDN1	IDA		Human	PMID:9492062
Biological Process	GO:0010737	protein kinase A signaling	EDN1	IDA		Human	PMID:30990108
Biological Process	GO:0042313	protein kinase C deactivation	EDN1	IDA		Human	PMID:16820593
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	Edn1	IDA		Mouse	PMID:2542249
Biological Process	GO:0006468	protein phosphorylation	Edn1	IDA		Mouse	PMID:31219639
Biological Process	GO:0008217	regulation of blood pressure	Edn1	IMP	MGI:MGI:3044563	Mouse	PMID:16868309
Biological Process	GO:0008217	regulation of blood pressure	Edn1	IMP	MGI:MGI:3044563	Mouse	PMID:20516397
Biological Process	GO:0008217	regulation of blood pressure	Edn1	IMP	MGI:MGI:3044563,MGI:MGI:3054057	Mouse	PMID:15314687
Biological Process	GO:0008217	regulation of blood pressure	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:8152482
Biological Process	GO:0008217	regulation of blood pressure	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:10626068
Biological Process	GO:0008217	regulation of blood pressure	Edn1	IMP		Rat	PMID:14707164|RGD:1580293
Biological Process	GO:0010827	regulation of glucose transmembrane transport	Edn1	IDA		Mouse	PMID:11546805
Biological Process	GO:0006885	regulation of pH	Edn1	IDA		Mouse	PMID:11413164
Biological Process	GO:0051930	regulation of sensory perception of pain	Edn1	IDA		Rat	PMID:19559389|RGD:4892558
Biological Process	GO:0003100	regulation of systemic arterial blood pressure by endothelin	EDN1	IDA		Human	PMID:2649896
Biological Process	GO:0070294	renal sodium ion absorption	Edn1	IDA		Mouse	PMID:23698114
Biological Process	GO:0007585	respiratory gaseous exchange by respiratory system	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:10626068
Biological Process	GO:0014823	response to activity	Edn1	IEP		Rat	PMID:15838345|RGD:8662289
Biological Process	GO:0043200	response to amino acid	Edn1	IEP		Rat	PMID:20871618|RGD:4144131
Biological Process	GO:0001975	response to amphetamine	Edn1	IMP		Mouse	PMID:24875861
Biological Process	GO:0071548	response to dexamethasone	Edn1	IEP		Rat	PMID:9888569|RGD:8662273
Biological Process	GO:0001666	response to hypoxia	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:8764295
Biological Process	GO:0001666	response to hypoxia	Edn1	IMP	MGI:MGI:1857637	Mouse	MGI:MGI:892631
Biological Process	GO:0001666	response to hypoxia	Edn1	IEP		Rat	PMID:12060564|RGD:625753
Biological Process	GO:0044321	response to leptin	Edn1	IEP		Rat	PMID:16144973|RGD:8662327
Biological Process	GO:0032496	response to lipopolysaccharide	Edn1	IEP		Rat	PMID:16360659|RGD:4144129
Biological Process	GO:0035994	response to muscle stretch	Edn1	IEP		Rat	PMID:16410403|RGD:7243951
Biological Process	GO:0035094	response to nicotine	Edn1	IEP		Rat	PMID:20854829|RGD:4144132
Biological Process	GO:0010193	response to ozone	Edn1	IEP		Rat	PMID:16081523|RGD:8662405
Biological Process	GO:0034696	response to prostaglandin F	Edn1	IEP		Rat	PMID:16947426|RGD:8662271
Biological Process	GO:1902074	response to salt	Edn1	IEP		Rat	PMID:7726830|RGD:8662278
Biological Process	GO:0033574	response to testosterone	Edn1	IEP		Rat	PMID:20660069|RGD:4144839
Biological Process	GO:0071559	response to transforming growth factor beta	Edn1	IEP		Rat	PMID:11061980|RGD:8662323
Biological Process	GO:0009410	response to xenobiotic stimulus	Edn1	IEP		Rat	PMID:20666571|RGD:4144838
Biological Process	GO:0009410	response to xenobiotic stimulus	Edn1	IEP		Rat	PMID:20851640|RGD:4144133
Biological Process	GO:0043179	rhythmic excitation	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:8764295
Biological Process	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	Edn1	IMP	MGI:MGI:2158947	Mouse	PMID:30735130
Biological Process	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	Edn1	IMP	MGI:MGI:2687362	Mouse	PMID:30735130
Biological Process	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:30735130
Biological Process	GO:0019233	sensory perception of pain	Edn1	IDA		Rat	PMID:19429182|RGD:4892559
Biological Process	GO:0001501	skeletal system development	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:8152482
Biological Process	GO:0006939	smooth muscle contraction	Edn1	IDA		Mouse	PMID:8010105
Biological Process	GO:0042554	superoxide anion generation	Edn1	IDA		Rat	PMID:16788136|RGD:4892602
Biological Process	GO:0097492	sympathetic neuron axon guidance	Edn1	IMP	MGI:MGI:2687362	Mouse	PMID:30735130
Biological Process	GO:0097492	sympathetic neuron axon guidance	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:30735130
Biological Process	GO:0097492	sympathetic neuron axon guidance	Edn1	IMP	MGI:MGI:2158947	Mouse	PMID:30735130
Biological Process	GO:0097492	sympathetic neuron axon guidance	Edn1	IMP	MGI:MGI:3718323	Mouse	PMID:30735130
Biological Process	GO:0030878	thyroid gland development	Edn1	IMP	MGI:MGI:1857637	Mouse	PMID:26506449
Biological Process	GO:0006366	transcription by RNA polymerase II	Edn1	IDA		Mouse	PMID:27026367
Biological Process	GO:0042310	vasoconstriction	EDN1	IDA		Human	PMID:11410113
Biological Process	GO:0042310	vasoconstriction	EDN1	IDA		Human	PMID:2649896
Biological Process	GO:0042310	vasoconstriction	Edn1	IDA		Rat	PMID:19628632|RGD:4892557
Biological Process	GO:0014826	vein smooth muscle contraction	EDN1	IDA		Human	PMID:9422810

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern