Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EDN2
  • Mouse genes Edn2
  • Rat genes Edn2
  • Zfish genes edn2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Edn2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031708	endothelin B receptor binding	EDN2	IPI	UniProtKB:P24530	Human	PMID:1713452
Molecular Function	GO:0005179	hormone activity	EDN2	IDA		Human	PMID:2649896
Cellular Component	GO:0005615	extracellular space	EDN2	IDA		Human	PMID:15691296
Cellular Component	GO:0005615	extracellular space	Edn2	IDA		Rat	PMID:1860178|RGD:1581821
Biological Process	GO:0001525	angiogenesis	Edn2	IDA		Mouse	PMID:24043815
Biological Process	GO:0001525	angiogenesis	Edn2	IGI	MGI:MGI:105923	Mouse	PMID:24043815
Biological Process	GO:0014824	artery smooth muscle contraction	EDN2	IDA		Human	PMID:8982507
Biological Process	GO:0048675	axon extension	Edn2	IDA		Mouse	PMID:18401410
Biological Process	GO:0019722	calcium-mediated signaling	EDN2	IDA		Human	PMID:1917960
Biological Process	GO:0009932	cell tip growth	Edn2	IDA		Mouse	PMID:24043815
Biological Process	GO:0019221	cytokine-mediated signaling pathway	EDN2	IDA		Human	PMID:12207323
Biological Process	GO:0043542	endothelial cell migration	Edn2	IDA		Mouse	PMID:24043815
Biological Process	GO:0097009	energy homeostasis	Edn2	IMP	MGI:MGI:5519239	Mouse	PMID:23676500
Biological Process	GO:0048016	inositol phosphate-mediated signaling	EDN2	IDA		Human	PMID:1917960
Biological Process	GO:0048286	lung alveolus development	Edn2	IMP	MGI:MGI:5519239	Mouse	PMID:23676500
Biological Process	GO:0042116	macrophage activation	EDN2	IDA		Human	PMID:12207323
Biological Process	GO:0048246	macrophage chemotaxis	EDN2	IDA		Human	PMID:12207323
Biological Process	GO:0046888	negative regulation of hormone secretion	Edn2	IDA		Rat	PMID:1533364|RGD:1581817
Biological Process	GO:0031175	neuron projection development	Edn2	IDA		Mouse	PMID:24875861
Biological Process	GO:0030593	neutrophil chemotaxis	EDN2	IDA		Human	PMID:9696419
Biological Process	GO:0001543	ovarian follicle rupture	Edn2	IDA		Rat	PMID:16410304|RGD:1581792
Biological Process	GO:0008284	positive regulation of cell population proliferation	EDN2	IDA		Human	PMID:1917960
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	EDN2	IDA		Human	PMID:1917960
Biological Process	GO:0010460	positive regulation of heart rate	EDN2	IDA		Human	PMID:2649896
Biological Process	GO:0046887	positive regulation of hormone secretion	Edn2	IDA		Rat	PMID:1533364|RGD:1581817
Biological Process	GO:0002690	positive regulation of leukocyte chemotaxis	EDN2	IDA		Human	PMID:9696419
Biological Process	GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity	EDN2	IMP		Human	PMID:9492062
Biological Process	GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity	Edn2	IMP		Mouse	MGI:MGI:3847878|PMID:9492062
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	Edn2	IDA		Mouse	PMID:2768235
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	Edn2	IDA		Rat	PMID:12396026|RGD:1581797
Biological Process	GO:0001516	prostaglandin biosynthetic process	EDN2	IDA		Human	PMID:9492062
Biological Process	GO:0001516	prostaglandin biosynthetic process	Edn2	IDA		Mouse	MGI:MGI:3847878|PMID:9492062
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	Edn2	IMP		Rat	PMID:1533364|RGD:1581817
Biological Process	GO:0003100	regulation of systemic arterial blood pressure by endothelin	EDN2	IDA		Human	PMID:2649896
Biological Process	GO:0006939	smooth muscle contraction	Edn2	IDA		Mouse	PMID:2768235
Biological Process	GO:0001659	temperature homeostasis	Edn2	IMP	MGI:MGI:5519239	Mouse	PMID:23676500
Biological Process	GO:0001944	vasculature development	Edn2	IDA		Mouse	PMID:24043815
Biological Process	GO:0042310	vasoconstriction	EDN2	IDA		Human	PMID:2649896
Biological Process	GO:0042310	vasoconstriction	EDN2	IDA		Human	PMID:8982507
Biological Process	GO:0014826	vein smooth muscle contraction	EDN2	IDA		Human	PMID:8982507
Biological Process	GO:0014826	vein smooth muscle contraction	EDN2	IDA		Human	PMID:9422810

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern