Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EDN3
  • Mouse genes Edn3
  • Rat genes Edn3
  • Zfish genes edn3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Edn3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031708	endothelin B receptor binding	EDN3	IPI	UniProtKB:P24530	Human	PMID:1713452
Molecular Function	GO:0005179	hormone activity	EDN3	IDA		Human	PMID:10770212
Molecular Function	GO:0005179	hormone activity	EDN3	IDA		Human	PMID:2649896
Cellular Component	GO:0005615	extracellular space	EDN3	IDA		Human	PMID:15691296
Biological Process	GO:0048675	axon extension	Edn3	IDA		Mouse	PMID:18401410
Biological Process	GO:0007411	axon guidance	Edn3	IMP	MGI:MGI:1857160	Mouse	PMID:18401410
Biological Process	GO:0008283	cell population proliferation	Edn3	IDA		Mouse	PMID:11401406
Biological Process	GO:0007166	cell surface receptor signaling pathway	EDN3	IDA		Human	PMID:1713452
Biological Process	GO:0051649	establishment of localization in cell	Edn3	IGI	MGI:MGI:1346053	Mouse	PMID:19544475
Biological Process	GO:0048016	inositol phosphate-mediated signaling	EDN3	IDA		Human	PMID:1917960
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Edn3	IGI	MGI:MGI:103569	Mouse	PMID:23122227
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Edn3	IGI	MGI:MGI:1346053	Mouse	PMID:23122227
Biological Process	GO:0010961	intracellular magnesium ion homeostasis	Edn3	IGI	MGI:MGI:1346053	Mouse	PMID:23122227
Biological Process	GO:0010961	intracellular magnesium ion homeostasis	Edn3	IGI	MGI:MGI:103569	Mouse	PMID:23122227
Biological Process	GO:0030318	melanocyte differentiation	Edn3	IDA		Mouse	PMID:9012511
Biological Process	GO:0030318	melanocyte differentiation	edn3b	IMP	ZFIN:ZDB-GENO-170425-4	Zfish	PMID:28181494
Biological Process	GO:0046888	negative regulation of hormone secretion	Edn3	IDA		Rat	PMID:1533364|RGD:1581817
Biological Process	GO:0001755	neural crest cell migration	Edn3	IMP	MGI:MGI:1856392	Mouse	PMID:9624616
Biological Process	GO:0030182	neuron differentiation	Edn3	IMP	MGI:MGI:1856392	Mouse	PMID:9624616
Biological Process	GO:0031175	neuron projection development	Edn3	IDA		Mouse	PMID:24875861
Biological Process	GO:0030593	neutrophil chemotaxis	EDN3	IDA		Human	PMID:9696419
Biological Process	GO:0030072	peptide hormone secretion	EDN3	IDA		Human	PMID:10770212
Biological Process	GO:0070285	pigment cell development	edn3b	IMP	ZFIN:ZDB-MRPHLNO-140924-2	Zfish	PMID:24857848
Biological Process	GO:0070285	pigment cell development	edn3b	IMP	ZFIN:ZDB-MRPHLNO-140924-1	Zfish	PMID:24857848
Biological Process	GO:0045597	positive regulation of cell differentiation	EDN3	IGI	UniProtKB:P39905	Human	PMID:22897442
Biological Process	GO:0008284	positive regulation of cell population proliferation	EDN3	IDA		Human	PMID:22897442
Biological Process	GO:0008284	positive regulation of cell population proliferation	Edn3	IDA		Mouse	PMID:11401406
Biological Process	GO:0010460	positive regulation of heart rate	EDN3	IDA		Human	PMID:2649896
Biological Process	GO:0046887	positive regulation of hormone secretion	EDN3	IDA		Human	PMID:10770212
Biological Process	GO:0002690	positive regulation of leukocyte chemotaxis	EDN3	IDA		Human	PMID:9696419
Biological Process	GO:0043406	positive regulation of MAP kinase activity	EDN3	IDA		Human	PMID:10770212
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	EDN3	IDA		Human	PMID:10770212
Biological Process	GO:1901381	positive regulation of potassium ion transmembrane transport	Edn3	IGI	MGI:MGI:1346053	Mouse	PMID:19544475
Biological Process	GO:0071805	potassium ion transmembrane transport	Edn3	IGI	MGI:MGI:1346053	Mouse	PMID:19544475
Biological Process	GO:0030334	regulation of cell migration	Edn3	IMP	MGI:MGI:1856392	Mouse	PMID:14138974
Biological Process	GO:0048070	regulation of developmental pigmentation	Edn3	IMP	MGI:MGI:1856392	Mouse	PMID:14138974
Biological Process	GO:0010468	regulation of gene expression	EDN3	IGI	UniProtKB:P39905	Human	PMID:22897442
Biological Process	GO:0046928	regulation of neurotransmitter secretion	Edn3	IDA		Rat	PMID:12184995|RGD:1299957
Biological Process	GO:0003100	regulation of systemic arterial blood pressure by endothelin	EDN3	IDA		Human	PMID:2649896
Biological Process	GO:0042310	vasoconstriction	EDN3	IDA		Human	PMID:2649896
Biological Process	GO:0042310	vasoconstriction	EDN3	IDA		Human	PMID:8982507
Biological Process	GO:0014826	vein smooth muscle contraction	EDN3	IDA		Human	PMID:8982507

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern