Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EDNRB
  • Mouse genes Ednrb
  • Rat genes Ednrb
  • Zfish genes ednrba,ednrbb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ednrb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004962	endothelin receptor activity	EDNRB	IDA		Human	PMID:1713452
Molecular Function	GO:0004962	endothelin receptor activity	EDNRB	IMP		Human	PMID:19767294
Molecular Function	GO:0004962	endothelin receptor activity	EDNRB	IMP		Human	PMID:28236341
Molecular Function	GO:0004962	endothelin receptor activity	Ednrb	IDA		Mouse	PMID:12441350
Molecular Function	GO:0004962	endothelin receptor activity	Ednrb	IMP	MGI:MGI:1857161	Mouse	PMID:11413164
Molecular Function	GO:0004962	endothelin receptor activity	Ednrb	IDA		Rat	PMID:2175397|RGD:730808
Molecular Function	GO:0017046	peptide hormone binding	EDNRB	IPI	UniProtKB:P05305	Human	PMID:1713452
Molecular Function	GO:0017046	peptide hormone binding	EDNRB	IPI	UniProtKB:P14138	Human	PMID:1713452
Molecular Function	GO:0017046	peptide hormone binding	EDNRB	IPI	UniProtKB:P20800	Human	PMID:1713452
Molecular Function	GO:0005515	protein binding	EDNRB	IPI	UniProtKB:P05305	Human	PMID:23597562
Molecular Function	GO:0005515	protein binding	Ednrb	IPI	PR:P22387	Mouse	PMID:12441350
Molecular Function	GO:0031702	type 1 angiotensin receptor binding	Ednrb	IPI	RGD:2070	Rat	PMID:16014039|RGD:1581862
Molecular Function	GO:0031702	type 1 angiotensin receptor binding	Ednrb	IPI	RGD:2071	Rat	PMID:16014039|RGD:1581862
Cellular Component	GO:0016020	membrane	Ednrb	IDA		Rat	PMID:11709437|RGD:628459
Cellular Component	GO:0045121	membrane raft	Ednrb	IDA		Rat	PMID:18288637|RGD:4892583
Cellular Component	GO:0031965	nuclear membrane	Ednrb	IDA		Rat	PMID:12756260|RGD:1581838
Cellular Component	GO:0005886	plasma membrane	EDNRB	IDA		Human	PMID:28236341
Cellular Component	GO:0005886	plasma membrane	Ednrb	IDA		Rat	PMID:16014039|RGD:1581862
Biological Process	GO:0007568	aging	Ednrb	IEP		Rat	PMID:16803983|RGD:4892600
Biological Process	GO:0032341	aldosterone metabolic process	Ednrb	IMP	MGI:MGI:3693642	Mouse	PMID:16868309
Biological Process	GO:0070588	calcium ion transmembrane transport	Ednrb	IMP		Mouse	PMID:24722437
Biological Process	GO:0070588	calcium ion transmembrane transport	Ednrb	IGI	MGI:MGI:105923	Mouse	PMID:24722437
Biological Process	GO:0070588	calcium ion transmembrane transport	Ednrb	IDA		Mouse	PMID:24722437
Biological Process	GO:0019722	calcium-mediated signaling	EDNRB	IMP		Human	PMID:28236341
Biological Process	GO:0060070	canonical Wnt signaling pathway	Ednrb	IGI	MGI:MGI:105923	Mouse	PMID:24722437
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Ednrb	IEP		Rat	PMID:18091567|RGD:4892289
Biological Process	GO:0019934	cGMP-mediated signaling	Ednrb	IMP		Rat	PMID:17585504|RGD:4892585
Biological Process	GO:0048066	developmental pigmentation	Ednrb	IMP	MGI:MGI:1856149	Mouse	PMID:15322542
Biological Process	GO:0048066	developmental pigmentation	ednrba	IMP	ZFIN:ZDB-GENO-101110-2	Zfish	PMID:23737760
Biological Process	GO:0086100	endothelin receptor signaling pathway	EDNRB	IDA		Human	PMID:1713452
Biological Process	GO:0086100	endothelin receptor signaling pathway	EDNRB	IMP		Human	PMID:19767294
Biological Process	GO:0086100	endothelin receptor signaling pathway	EDNRB	IMP		Human	PMID:28236341
Biological Process	GO:0086100	endothelin receptor signaling pathway	Ednrb	IGI	MGI:MGI:105923	Mouse	PMID:24722437
Biological Process	GO:0048484	enteric nervous system development	Ednrb	IDA		Mouse	MGI:MGI:1330409|PMID:10021336
Biological Process	GO:0035645	enteric smooth muscle cell differentiation	Ednrb	IDA		Mouse	MGI:MGI:1330409|PMID:10021336
Biological Process	GO:0042045	epithelial fluid transport	Ednrb	IMP		Rat	PMID:18948426|RGD:4892575
Biological Process	GO:0061028	establishment of endothelial barrier	Ednrb	IDA		Mouse	PMID:27026367
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Ednrb	IDA		Mouse	PMID:12441350
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Ednrb	IGI	MGI:MGI:95768	Mouse	PMID:12441350
Biological Process	GO:0010467	gene expression	Ednrb	IGI	MGI:MGI:105923	Mouse	PMID:24722437
Biological Process	GO:0010467	gene expression	Ednrb	IGI	MGI:MGI:102720	Mouse	PMID:24722437
Biological Process	GO:0010467	gene expression	Ednrb	IMP		Mouse	PMID:18199583
Biological Process	GO:0030202	heparin metabolic process	Ednrb	IGI	MGI:MGI:105923	Mouse	PMID:27026367
Biological Process	GO:0030202	heparin metabolic process	Ednrb	IGI	MGI:MGI:102720	Mouse	PMID:27026367
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Ednrb	IGI	MGI:MGI:105923	Mouse	PMID:24722437
Biological Process	GO:0050935	iridophore differentiation	ednrba	IMP	ZFIN:ZDB-GENO-140819-5	Zfish	PMID:23821036
Biological Process	GO:0048246	macrophage chemotaxis	EDNRB	IMP		Human	PMID:12207323
Biological Process	GO:0030318	melanocyte differentiation	Ednrb	IDA		Mouse	PMID:9012511
Biological Process	GO:0030318	melanocyte differentiation	Ednrb	IMP	MGI:MGI:1856148	Mouse	PMID:2379821
Biological Process	GO:0030318	melanocyte differentiation	Ednrb	IDA		Rat	PMID:11709437|RGD:628459
Biological Process	GO:0043066	negative regulation of apoptotic process	Ednrb	IMP		Rat	PMID:18683040|RGD:4892578
Biological Process	GO:0014043	negative regulation of neuron maturation	Ednrb	IDA		Mouse	MGI:MGI:1330409|PMID:10021336
Biological Process	GO:0051248	negative regulation of protein metabolic process	EDNRB	IMP		Human	PMID:19767294
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	EDNRB	IMP		Human	PMID:19767294
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Ednrb	IDA		Mouse	MGI:MGI:1330409|PMID:10021336
Biological Process	GO:0001755	neural crest cell migration	Ednrb	IMP		Mouse	PMID:10591209
Biological Process	GO:0097402	neuroblast migration	Ednrb	IMP		Mouse	PMID:10591209
Biological Process	GO:0007422	peripheral nervous system development	Ednrb	IMP	MGI:MGI:1856149	Mouse	PMID:8582288
Biological Process	GO:0060465	pharynx development	Ednrb	IDA		Mouse	PMID:18199583
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	Ednrb	IMP		Rat	PMID:15245872|RGD:1581866
Biological Process	GO:0043473	pigmentation	Ednrb	IMP	MGI:MGI:1856148	Mouse	PMID:2379821
Biological Process	GO:0043473	pigmentation	Ednrb	IMP		Rat	PMID:8570650|RGD:628515
Biological Process	GO:0072112	podocyte differentiation	Ednrb	IGI	MGI:MGI:105923	Mouse	PMID:24722437
Biological Process	GO:0072112	podocyte differentiation	Ednrb	IGI	MGI:MGI:102720	Mouse	PMID:24722437
Biological Process	GO:0008284	positive regulation of cell population proliferation	Ednrb	IMP		Rat	PMID:18683040|RGD:4892578
Biological Process	GO:0008284	positive regulation of cell population proliferation	Ednrb	IMP		Rat	PMID:19628632|RGD:4892557
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Ednrb	IDA		Rat	PMID:2175397|RGD:730808
Biological Process	GO:0060406	positive regulation of penile erection	Ednrb	IMP		Rat	PMID:19884966|RGD:4892342
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Ednrb	IDA		Rat	PMID:16014039|RGD:1581862
Biological Process	GO:0035815	positive regulation of renal sodium excretion	Ednrb	IMP		Rat	PMID:18305094|RGD:4892582
Biological Process	GO:0035810	positive regulation of urine volume	Ednrb	IMP		Rat	PMID:18305094|RGD:4892582
Biological Process	GO:0007497	posterior midgut development	Ednrb	IMP	MGI:MGI:1856149	Mouse	PMID:8582288
Biological Process	GO:0071806	protein transmembrane transport	Ednrb	IDA		Mouse	PMID:27026367
Biological Process	GO:0008217	regulation of blood pressure	Ednrb	IMP		Mouse	PMID:16399858
Biological Process	GO:0008217	regulation of blood pressure	Ednrb	IGI	MGI:MGI:105923	Mouse	PMID:16399858
Biological Process	GO:0008217	regulation of blood pressure	Ednrb	IMP	MGI:MGI:3693642	Mouse	PMID:16868309
Biological Process	GO:0008217	regulation of blood pressure	Ednrb	IGI	MGI:MGI:102720	Mouse	PMID:18784261
Biological Process	GO:0008217	regulation of blood pressure	Ednrb	IGI	MGI:MGI:105923	Mouse	PMID:18784261
Biological Process	GO:0008217	regulation of blood pressure	Ednrb	IMP	MGI:MGI:1857161	Mouse	PMID:10626068
Biological Process	GO:0008217	regulation of blood pressure	Ednrb	IMP		Rat	PMID:16763077|RGD:1601009
Biological Process	GO:0048070	regulation of developmental pigmentation	ednrba	IMP	ZFIN:ZDB-GENO-140819-5	Zfish	PMID:23821036
Biological Process	GO:0050678	regulation of epithelial cell proliferation	Ednrb	IMP		Rat	PMID:12538737|RGD:1581844
Biological Process	GO:0031620	regulation of fever generation	Ednrb	IMP		Rat	PMID:16123229|RGD:1581859
Biological Process	GO:0002027	regulation of heart rate	Ednrb	IMP		Mouse	PMID:16399858
Biological Process	GO:0002027	regulation of heart rate	Ednrb	IGI	MGI:MGI:105923	Mouse	PMID:16399858
Biological Process	GO:0006885	regulation of pH	Ednrb	IMP	MGI:MGI:1857161	Mouse	PMID:11413164
Biological Process	GO:0051930	regulation of sensory perception of pain	Ednrb	IMP		Rat	PMID:12847519|RGD:1581889
Biological Process	GO:0097018	renal albumin absorption	Ednrb	IGI	MGI:MGI:102720	Mouse	PMID:24722437
Biological Process	GO:0097018	renal albumin absorption	Ednrb	IGI	MGI:MGI:105923	Mouse	PMID:24722437
Biological Process	GO:0035812	renal sodium excretion	Ednrb	IMP	MGI:MGI:3693642	Mouse	PMID:16868309
Biological Process	GO:0070294	renal sodium ion absorption	Ednrb	IMP		Mouse	PMID:23698114
Biological Process	GO:0002001	renin secretion into blood stream	Ednrb	IMP	MGI:MGI:3693642	Mouse	PMID:16868309
Biological Process	GO:1990839	response to endothelin	Ednrb	IMP		Rat	PMID:10749572|RGD:628518
Biological Process	GO:0032496	response to lipopolysaccharide	Ednrb	IMP		Rat	PMID:20888431|RGD:4892334
Biological Process	GO:0014070	response to organic cyclic compound	Ednrb	IEP		Rat	PMID:19851775|RGD:4892287
Biological Process	GO:0010033	response to organic substance	Ednrb	IGI	MGI:MGI:105923	Mouse	PMID:24722437
Biological Process	GO:0010033	response to organic substance	Ednrb	IGI	MGI:MGI:105923	Mouse	PMID:27026367
Biological Process	GO:0048265	response to pain	Ednrb	IMP		Rat	PMID:12847519|RGD:1581889
Biological Process	GO:1904383	response to sodium phosphate	Ednrb	IMP	MGI:MGI:3693642	Mouse	PMID:16868309
Biological Process	GO:0019233	sensory perception of pain	Ednrb	IMP		Rat	PMID:20450894|RGD:4892337
Biological Process	GO:0055078	sodium ion homeostasis	Ednrb	IGI	MGI:MGI:105923	Mouse	PMID:18784261
Biological Process	GO:0042310	vasoconstriction	EDNRB	IMP		Human	PMID:8982507
Biological Process	GO:0042310	vasoconstriction	Ednrb	IMP		Rat	PMID:14678950|RGD:1581832
Biological Process	GO:0042311	vasodilation	Ednrb	IMP		Rat	PMID:14678950|RGD:1581832
Biological Process	GO:0014826	vein smooth muscle contraction	EDNRB	IMP		Human	PMID:8982507

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern