Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EFEMP2
  • Mouse genes Efemp2
  • Rat genes Efemp2
  • Zfish genes efemp2a,efemp2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Efemp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008201	heparin binding	EFEMP2	IDA		Human	PMID:23782690
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:O43765	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q96EQ0	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9BQY4	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9UMX0	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P15502	Human	PMID:16478991
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P54253	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P54259	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9UMX0	Human	PMID:16713569
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P35555	Human	PMID:19349279
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P15502	Human	PMID:19570982
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P28300	Human	PMID:19570982
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P35555	Human	PMID:19570982
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9UBX5	Human	PMID:19570982
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P28300	Human	PMID:19855011
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P28300	Human	PMID:22919265
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P09022	Human	PMID:23088713
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:O43765	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:O75716	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P43115-12	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P50222	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P56524	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q02930-3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q5T5A8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q5TA82	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q5TZK3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q7Z417	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q7Z6I8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q93062	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q96EQ0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9UMX0-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q8WWY3	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9Y4X0	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P01137|UniProtKB:P28300|UniProtKB:Q08397|UniProtKB:Q14766|UniProtKB:Q8N2S1|UniProtKB:Q9NS15|UniProtKB:Q9Y4K0	Human	PMID:27339457
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q96EQ0	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:A0A024R4B0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:B1ATL7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:O15375	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:O43711	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:O43765	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:O75360	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:O75716	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P01024	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P10745	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P18084	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P24592	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P32242	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P37235	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P42830	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P46379-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P50539-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P52815	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P52954	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P59991	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P60410	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P78337	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q02930-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q08117-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q0VD86	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q12829	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q13351	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q14005-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q14585	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q16740	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q18PE1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q32M78	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q3LI72	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q3SY46	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q5T5B0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q5T751	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q5T753	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q5T7P2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q5TA76	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q5TA81	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q68EA5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q6NSM0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q6NVV7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q6NX45	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q6PEX3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q6RVD6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q6UY14-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q6ZT89-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q7Z417	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q86W54-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q86YD7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q8IUC1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q8IWZ5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q8NE01	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q8TBB1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q8WVD3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q8WWY3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q969U6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q96B67	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q96E40	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q96EG3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q96EQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q96JK4-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q96MM6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q96NG5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q96RU7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q96SQ5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q99572	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q99750	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9BQ89	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9BS34	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9BT49	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9BXS5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9BYE3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9BYR7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9C004	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9C0B1-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9H2F3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9H5H4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9NYG5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9NYW8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9P0T4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9P121-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9UHI7-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9UK80	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9UMX0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:Q9Y4X0-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EFEMP2	IPI	UniProtKB:P54253	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Efemp2	IPI	UniProtKB:Q8K4G1-1|UniProtKB:Q8K4G1-2	Mouse	MGI:MGI:5638486|PMID:25713297
Molecular Function	GO:0005515	protein binding	Efemp2	IPI	UniProtKB:O35206|UniProtKB:O88322|UniProtKB:P15502|UniProtKB:P39061	Mouse	MGI:MGI:3709425|PMID:17324935
Molecular Function	GO:0005515	protein binding	Efemp2	IPI	UniProtKB:Q61398	Mouse	MGI:MGI:5695689|PMID:26220971
Molecular Function	GO:0005515	protein binding	Efemp2	IPI	UniProtKB:Q99K41	Mouse	MGI:MGI:6478060|PMID:28717224
Molecular Function	GO:0005515	protein binding	Efemp2	IPI	UniProtKB:P04985	Mouse	MGI:MGI:3619755|PMID:16478991
Molecular Function	GO:0005515	protein binding	Efemp2	IPI	PR:P28301	Mouse	PMID:19855011
Molecular Function	GO:0042803	protein homodimerization activity	EFEMP2	IDA		Human	PMID:23782690
Cellular Component	GO:0005604	basement membrane	Efemp2	IDA		Mouse	MGI:MGI:3709425|PMID:17324935
Cellular Component	GO:0062023	collagen-containing extracellular matrix	EFEMP2	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Efemp2	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0071953	elastic fiber	EFEMP2	IDA		Human	PMID:27339457
Cellular Component	GO:0071953	elastic fiber	Efemp2	IMP		Mouse	MGI:MGI:3619755|PMID:16478991
Cellular Component	GO:0070062	extracellular exosome	EFEMP2	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	EFEMP2	HDA		Human	PMID:23533145
Cellular Component	GO:0031012	extracellular matrix	EFEMP2	IDA		Human	PMID:20389311
Cellular Component	GO:0031012	extracellular matrix	EFEMP2	IDA		Human	PMID:27339457
Cellular Component	GO:0031012	extracellular matrix	Efemp2	IDA		Mouse	MGI:MGI:5776647|PMID:26690653
Cellular Component	GO:0031012	extracellular matrix	Efemp2	IDA		Mouse	MGI:MGI:3709425|PMID:17324935
Cellular Component	GO:0005615	extracellular space	Efemp2	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:1903561	extracellular vesicle	EFEMP2	HDA		Human	PMID:24769233
Cellular Component	GO:0001527	microfibril	Efemp2	IDA		Mouse	MGI:MGI:3709425|PMID:17324935
Biological Process	GO:0035904	aorta development	Efemp2	IMP		Mouse	MGI:MGI:4947512|PMID:20019329
Biological Process	GO:0060414	aorta smooth muscle tissue morphogenesis	Efemp2	IMP		Mouse	MGI:MGI:6158865|PMID:26711913
Biological Process	GO:0060414	aorta smooth muscle tissue morphogenesis	Efemp2	IMP		Mouse	MGI:MGI:5660411|PMID:26178373
Biological Process	GO:0060840	artery development	Efemp2	IMP	MGI:MGI:4410301	Mouse	PMID:19855011
Biological Process	GO:0048251	elastic fiber assembly	EFEMP2	IMP		Human	PMID:18973305
Biological Process	GO:0048251	elastic fiber assembly	EFEMP2	IMP		Human	PMID:27339457
Biological Process	GO:0048251	elastic fiber assembly	Efemp2	IMP		Mouse	MGI:MGI:3619755|PMID:16478991
Biological Process	GO:0048251	elastic fiber assembly	Efemp2	IMP		Mouse	MGI:MGI:5660411|PMID:26178373
Biological Process	GO:0048251	elastic fiber assembly	Efemp2	IMP		Mouse	MGI:MGI:6158865|PMID:26711913
Biological Process	GO:0048251	elastic fiber assembly	Efemp2	IMP		Mouse	MGI:MGI:4947512|PMID:20019329
Biological Process	GO:0048251	elastic fiber assembly	Efemp2	IMP		Mouse	MGI:MGI:6140729|PMID:28508064
Biological Process	GO:0048251	elastic fiber assembly	Efemp2	IMP	MGI:MGI:4410301	Mouse	PMID:19855011
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	Efemp2	IMP		Mouse	MGI:MGI:5584046|PMID:23636094
Biological Process	GO:1904831	positive regulation of aortic smooth muscle cell differentiation	Efemp2	IMP		Mouse	MGI:MGI:4947512|PMID:20019329
Biological Process	GO:1904028	positive regulation of collagen fibril organization	Efemp2	IMP		Mouse	MGI:MGI:5695689|PMID:26220971
Biological Process	GO:1904028	positive regulation of collagen fibril organization	Efemp2	IMP		Mouse	MGI:MGI:5660411|PMID:26178373
Biological Process	GO:1904028	positive regulation of collagen fibril organization	Efemp2	IMP		Mouse	MGI:MGI:6158865|PMID:26711913
Biological Process	GO:1905609	positive regulation of smooth muscle cell-matrix adhesion	EFEMP2	IMP		Human	PMID:23782690
Biological Process	GO:1904026	regulation of collagen fibril organization	Efemp2	IMP		Mouse	MGI:MGI:5776647|PMID:26690653
Biological Process	GO:0097084	vascular associated smooth muscle cell development	Efemp2	IMP		Mouse	MGI:MGI:5584046|PMID:23636094

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern