Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EFNA1
  • Mouse genes Efna1
  • Rat genes Efna1
  • Zfish genes efna1a,efna1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Efna1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0046875	ephrin receptor binding	EFNA1	IPI	UniProtKB:P29320|UniProtKB:Q60750	Human	PMID:11519828
Molecular Function	GO:0046875	ephrin receptor binding	EFNA1	IPI	UniProtKB:P29317	Human	PMID:15777695
Molecular Function	GO:0046875	ephrin receptor binding	Efna1	IPI	UniProtKB:O09127	Mouse	MGI:MGI:6478053|PMID:22568954
Molecular Function	GO:0046875	ephrin receptor binding	Efna1	IPI	UniProtKB:P29317	Mouse	MGI:MGI:6478053|PMID:22568954
Molecular Function	GO:0005515	protein binding	EFNA1	IPI	UniProtKB:P29317	Human	PMID:19525919
Molecular Function	GO:0005515	protein binding	EFNA1	IPI	UniProtKB:P29317	Human	PMID:19573808
Molecular Function	GO:0005515	protein binding	EFNA1	IPI	UniProtKB:P29317	Human	PMID:20505120
Molecular Function	GO:0005515	protein binding	EFNA1	IPI	UniProtKB:P29317	Human	PMID:22244754
Molecular Function	GO:0005515	protein binding	Efna1	IPI	UniProtKB:Q15375	Mouse	MGI:MGI:5315323|PMID:22036564
Cellular Component	GO:0005886	plasma membrane	Efna1	IDA		Mouse	MGI:MGI:4412436|PMID:18794797
Biological Process	GO:0003180	aortic valve morphogenesis	Efna1	IMP		Mouse	MGI:MGI:4847981|PMID:20960543
Biological Process	GO:0016477	cell migration	EFNA1	IDA		Human	PMID:10655584
Biological Process	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation	Efna1	IMP		Mouse	MGI:MGI:4847981|PMID:20960543
Biological Process	GO:0048013	ephrin receptor signaling pathway	EFNA1	IDA		Human	PMID:10655584
Biological Process	GO:0048013	ephrin receptor signaling pathway	EFNA1	IGI	UniProtKB:P54764	Human	PMID:24217950
Biological Process	GO:0048013	ephrin receptor signaling pathway	Efna1	IDA		Mouse	MGI:MGI:3696283|PMID:17143272
Biological Process	GO:0048013	ephrin receptor signaling pathway	Efna1	IDA		Mouse	PMID:14988728
Biological Process	GO:0048013	ephrin receptor signaling pathway	Efna1	IDA		Mouse	PMID:15145949
Biological Process	GO:0003183	mitral valve morphogenesis	Efna1	IMP		Mouse	MGI:MGI:4847981|PMID:20960543
Biological Process	GO:0061002	negative regulation of dendritic spine morphogenesis	Efna1	IDA		Mouse	MGI:MGI:3696283|PMID:17143272
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	Efna1	IMP		Mouse	MGI:MGI:4847981|PMID:20960543
Biological Process	GO:0043409	negative regulation of MAPK cascade	Efna1	IDA		Mouse	PMID:16547242
Biological Process	GO:1903051	negative regulation of proteolysis involved in protein catabolic process	EFNA1	IGI	UniProtKB:P54764	Human	PMID:24217950
Biological Process	GO:0070244	negative regulation of thymocyte apoptotic process	Efna1	IDA		Mouse	PMID:16547242
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Efna1	IMP		Mouse	MGI:MGI:4847981|PMID:20960543
Biological Process	GO:0030182	neuron differentiation	Efna1	IDA		Mouse	PMID:15145949
Biological Process	GO:0014028	notochord formation	Efna1	IGI	MGI:MGI:95278	Mouse	PMID:11287184
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	EFNA1	IDA		Human	PMID:24217950
Biological Process	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	EFNA1	IGI	UniProtKB:P54764	Human	PMID:24217950
Biological Process	GO:0043410	positive regulation of MAPK cascade	Efna1	IDA		Mouse	PMID:15145949
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	EFNA1	IDA		Human	PMID:10655584
Biological Process	GO:0001934	positive regulation of protein phosphorylation	EFNA1	IGI	UniProtKB:P07948	Human	PMID:24217950
Biological Process	GO:0001934	positive regulation of protein phosphorylation	EFNA1	IGI	UniProtKB:P54764	Human	PMID:24217950
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	EFNA1	IGI	UniProtKB:P54764	Human	PMID:24217950
Biological Process	GO:0050821	protein stabilization	EFNA1	IGI	UniProtKB:P54764	Human	PMID:24217950
Biological Process	GO:0045765	regulation of angiogenesis	Efna1	IDA		Mouse	MGI:MGI:3640033|PMID:16782872
Biological Process	GO:0050770	regulation of axonogenesis	Efna1	IDA		Mouse	PMID:14988728
Biological Process	GO:0043535	regulation of blood vessel endothelial cell migration	Efna1	IDA		Mouse	MGI:MGI:3640033|PMID:16782872
Biological Process	GO:0033628	regulation of cell adhesion mediated by integrin	EFNA1	IDA		Human	PMID:10655584
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	Efna1	IDA		Mouse	MGI:MGI:3696283|PMID:17143272
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	EFNA1	IDA		Human	PMID:10655584

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern