Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EGF
  • Mouse genes Egf
  • Rat genes Egf
  • Zfish genes egf
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Egf

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005154	epidermal growth factor receptor binding	Egf	IDA		Mouse	PMID:7678348
Molecular Function	GO:0005154	epidermal growth factor receptor binding	Egf	IDA		Mouse	PMID:6315706
Molecular Function	GO:0005154	epidermal growth factor receptor binding	Egf	IDA		Rat	PMID:2260661|RGD:1626483
Molecular Function	GO:0008083	growth factor activity	EGF	IDA		Human	PMID:15611079
Molecular Function	GO:0008083	growth factor activity	EGF	IDA		Human	PMID:7736574
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	EGF	IDA		Human	PMID:20353436
Molecular Function	GO:0005515	protein binding	EGF	IPI	UniProtKB:P00533	Human	PMID:12297050
Molecular Function	GO:0005515	protein binding	EGF	IPI	UniProtKB:P00533	Human	PMID:12620237
Molecular Function	GO:0005515	protein binding	EGF	IPI	UniProtKB:P00533	Human	PMID:17697999
Molecular Function	GO:0005515	protein binding	EGF	IPI	UniProtKB:P00533	Human	PMID:21439278
Molecular Function	GO:0005515	protein binding	EGF	IPI	UniProtKB:Q01279	Human	PMID:21439278
Molecular Function	GO:0005515	protein binding	EGF	IPI	UniProtKB:P00533	Human	PMID:21822280
Molecular Function	GO:0005515	protein binding	EGF	IPI	UniProtKB:P00533	Human	PMID:23597562
Molecular Function	GO:0005515	protein binding	EGF	IPI	UniProtKB:P00533	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	EGF	IPI	UniProtKB:P00533	Human	PMID:26280537
Molecular Function	GO:0005515	protein binding	EGF	IPI	UniProtKB:P00533	Human	PMID:2790960
Molecular Function	GO:0005515	protein binding	EGF	IPI	UniProtKB:P00533	Human	PMID:28988771
Molecular Function	GO:0005515	protein binding	EGF	IPI	UniProtKB:P00533	Human	PMID:30083275
Molecular Function	GO:0005515	protein binding	EGF	IPI	UniProtKB:P10620	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EGF	IPI	UniProtKB:P00533	Human	PMID:9135143
Molecular Function	GO:0005515	protein binding	Egf	IPI	UniProtKB:Q8VD37	Mouse	MGI:MGI:4887327|PMID:17626015
Molecular Function	GO:0048018	receptor ligand activity	EGF	IDA		Human	PMID:11336639
Molecular Function	GO:0048018	receptor ligand activity	Egf	IDA		Mouse	PMID:6248866
Molecular Function	GO:0048018	receptor ligand activity	Egf	IDA		Mouse	PMID:7752576
Molecular Function	GO:0048018	receptor ligand activity	Egf	IDA		Mouse	PMID:22822073
Molecular Function	GO:0048018	receptor ligand activity	Egf	IDA		Mouse	PMID:9529375
Molecular Function	GO:0048018	receptor ligand activity	Egf	IDA		Mouse	PMID:12761849
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	EGF	IDA		Human	PMID:11336639
Cellular Component	GO:0070062	extracellular exosome	EGF	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	EGF	IDA		Human	PMID:21082674
Cellular Component	GO:0070062	extracellular exosome	EGF	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	EGF	IDA		Human	PMID:11336639
Cellular Component	GO:0005615	extracellular space	EGF	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	Egf	IDA		Mouse	PMID:7752576
Cellular Component	GO:0005615	extracellular space	Egf	IDA		Mouse	PMID:6248866
Cellular Component	GO:0005615	extracellular space	Egf	IDA		Mouse	PMID:22822073
Cellular Component	GO:0005615	extracellular space	Egf	IDA		Mouse	PMID:12761849
Cellular Component	GO:0005615	extracellular space	Egf	IDA		Mouse	PMID:7641815
Cellular Component	GO:0005615	extracellular space	Egf	IDA		Mouse	PMID:8240367
Cellular Component	GO:0005615	extracellular space	Egf	IDA		Rat	PMID:3257897|RGD:10059688
Cellular Component	GO:0005765	lysosomal membrane	EGF	HDA		Human	PMID:17897319
Cellular Component	GO:0005886	plasma membrane	Egf	IDA		Mouse	MGI:MGI:4887327|PMID:17626015
Biological Process	GO:0001525	angiogenesis	EGF	IDA		Human	PMID:15611079
Biological Process	GO:0008015	blood circulation	egf	IMP	ZFIN:ZDB-MRPHLNO-140306-7	Zfish	PMID:24262764
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	Egf	IDA		Mouse	PMID:15831470
Biological Process	GO:0051216	cartilage development	egf	IMP	ZFIN:ZDB-MRPHLNO-140306-7	Zfish	PMID:24262764
Biological Process	GO:0008283	cell population proliferation	Egf	IGI	MGI:MGI:96522	Mouse	PMID:15509736
Biological Process	GO:0021930	cerebellar granule cell precursor proliferation	Egf	IDA		Mouse	PMID:10027293
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	EGF	IDA		Human	PMID:18567582
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	EGF	IDA		Human	PMID:31915155
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Egf	IDA		Mouse	PMID:7752576
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Egf	IDA		Mouse	PMID:6248866
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Egf	IDA		Mouse	PMID:9529375
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Egf	IDA		Mouse	PMID:12761849
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Egf	IGI	MGI:MGI:95294	Mouse	PMID:7641815
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Egf	IDA		Mouse	PMID:6315706
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Egf	IDA		Mouse	PMID:15695332
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Egf	IDA		Rat	PMID:2260661|RGD:1626483
Biological Process	GO:0038029	epidermal growth factor receptor signaling pathway via MAPK cascade	EGF	IMP		Human	PMID:18722344
Biological Process	GO:0050673	epithelial cell proliferation	Egf	IGI	MGI:MGI:96522	Mouse	PMID:15509736
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	EGF	IDA		Human	PMID:11336639
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	Egf	IDA		Mouse	PMID:22822073
Biological Process	GO:0070371	ERK1 and ERK2 cascade	EGF	IDA		Human	PMID:16314496
Biological Process	GO:0001822	kidney development	Egf	IEP		Rat	PMID:1570198|RGD:10059692
Biological Process	GO:0060749	mammary gland alveolus development	Egf	IGI	MGI:MGI:98724	Mouse	PMID:10331984
Biological Process	GO:0060749	mammary gland alveolus development	Egf	IGI	MGI:MGI:88068	Mouse	PMID:10331984
Biological Process	GO:0090370	negative regulation of cholesterol efflux	Egf	IDA		Mouse	MGI:MGI:4460848|PMID:20037141
Biological Process	GO:0051048	negative regulation of secretion	EGF	IDA		Human	PMID:10559227
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Egf	IDA		Mouse	PMID:14561752
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	EGF	IDA		Human	PMID:20302655
Biological Process	GO:0030335	positive regulation of cell migration	EGF	IDA		Human	PMID:25678558
Biological Process	GO:0008284	positive regulation of cell population proliferation	EGF	IDA		Human	PMID:7736574
Biological Process	GO:0008284	positive regulation of cell population proliferation	EGF	IDA		Human	PMID:15611079
Biological Process	GO:0008284	positive regulation of cell population proliferation	EGF	IDA		Human	PMID:20388803
Biological Process	GO:0008284	positive regulation of cell population proliferation	Egf	IDA		Mouse	PMID:14712229
Biological Process	GO:0008284	positive regulation of cell population proliferation	Egf	IGI	MGI:MGI:95294	Mouse	PMID:7641815
Biological Process	GO:0008284	positive regulation of cell population proliferation	Egf	IGI	MGI:MGI:95705	Mouse	PMID:7641815
Biological Process	GO:0008284	positive regulation of cell population proliferation	Egf	IDA		Mouse	PMID:15695332
Biological Process	GO:0008284	positive regulation of cell population proliferation	Egf	IDA		Mouse	PMID:8702723
Biological Process	GO:0008284	positive regulation of cell population proliferation	Egf	IGI	MGI:MGI:95516	Mouse	PMID:15051883
Biological Process	GO:0021940	positive regulation of cerebellar granule cell precursor proliferation	Egf	IDA		Mouse	PMID:10027293
Biological Process	GO:0043388	positive regulation of DNA binding	Egf	IDA		Mouse	MGI:MGI:5284803|PMID:15156153
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	Egf	IDA		Rat	PMID:3093142|RGD:10395243
Biological Process	GO:0045740	positive regulation of DNA replication	EGF	IMP		Human	PMID:18722344
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	EGF	IDA		Human	PMID:16314496
Biological Process	GO:0010595	positive regulation of endothelial cell migration	EGF	IDA		Human	PMID:31915155
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	EGF	IDA		Human	PMID:31915155
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	EGF	IDA		Human	PMID:15611079
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	EGF	IDA		Human	PMID:20353436
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	EGF	IMP		Human	PMID:22732145
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Egf	IGI	MGI:MGI:96522	Mouse	PMID:15509736
Biological Process	GO:1905278	positive regulation of epithelial tube formation	EGF	IDA		Human	PMID:31915155
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Egf	IDA		Rat	PMID:17310240|RGD:1626216
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	Egf	IDA		Rat	PMID:3093142|RGD:10395243
Biological Process	GO:0010628	positive regulation of gene expression	EGF	IDA		Human	PMID:25678558
Biological Process	GO:1900127	positive regulation of hyaluronan biosynthetic process	EGF	IDA		Human	PMID:17324121
Biological Process	GO:0043406	positive regulation of MAP kinase activity	EGF	IDA		Human	PMID:15611079
Biological Process	GO:0043410	positive regulation of MAPK cascade	EGF	IDA		Human	PMID:18567582
Biological Process	GO:0043410	positive regulation of MAPK cascade	EGF	IDA		Human	PMID:31915155
Biological Process	GO:0043410	positive regulation of MAPK cascade	Egf	IDA		Mouse	PMID:9030684
Biological Process	GO:0043410	positive regulation of MAPK cascade	Egf	IDA		Mouse	PMID:16339969
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	EGF	IDA		Human	PMID:15611079
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	EGF	IDA		Human	PMID:16314496
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Egf	IDA		Mouse	PMID:21186272
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	EGF	IGI	UniProtKB:O00329	Human	PMID:31915155
Biological Process	GO:0042327	positive regulation of phosphorylation	EGF	IDA		Human	PMID:15611079
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	EGF	IDA		Human	PMID:31915155
Biological Process	GO:1902966	positive regulation of protein localization to early endosome	EGF	IDA		Human	PMID:22298428
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	Egf	IDA		Mouse	PMID:7678348
Biological Process	GO:0002092	positive regulation of receptor internalization	EGF	IDA		Human	PMID:22732145
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	Egf	IDA		Mouse	MGI:MGI:4887523|PMID:20208556
Biological Process	GO:0090279	regulation of calcium ion import	EGF	IDA		Human	PMID:19996314
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	Egf	IDA		Mouse	PMID:11940581
Biological Process	GO:2000008	regulation of protein localization to cell surface	EGF	IDA		Human	PMID:19996314
Biological Process	GO:0050708	regulation of protein secretion	Egf	IMP		Rat	PMID:12388118|RGD:629545
Biological Process	GO:0051223	regulation of protein transport	Egf	IDA		Rat	PMID:19723622|RGD:8554041
Biological Process	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	Egf	IDA		Mouse	MGI:MGI:5284803|PMID:15156153

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern