Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EGFL6
  • Mouse genes Egfl6
  • Rat genes Egfl6
  • Zfish genes egfl6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Egfl6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005178	integrin binding	egfl6	IMP	ZFIN:ZDB-GENO-180523-5	Zfish	PMID:27780917
Molecular Function	GO:0005178	integrin binding	egfl6	IMP		Zfish	PMID:27780917
Molecular Function	GO:0005515	protein binding	EGFL6	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0048018	receptor ligand activity	egfl6	IMP		Zfish	PMID:27780917
Cellular Component	GO:0005604	basement membrane	Egfl6	IDA		Mouse	PMID:18757743
Cellular Component	GO:0031012	extracellular matrix	Egfl6	IDA		Mouse	PMID:18757743
Biological Process	GO:0070371	ERK1 and ERK2 cascade	egfl6	IMP	ZFIN:ZDB-GENO-180523-5	Zfish	PMID:27780917
Biological Process	GO:0030198	extracellular matrix organization	Egfl6	IDA		Mouse	PMID:18757743
Biological Process	GO:0030903	notochord development	egfl6	IMP	ZFIN:ZDB-MRPHLNO-151116-5	Zfish	PMID:25952972
Biological Process	GO:0030903	notochord development	egfl6	IMP	ZFIN:ZDB-MRPHLNO-151116-4	Zfish	PMID:25952972
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	egfl6	IMP	ZFIN:ZDB-GENO-180523-5	Zfish	PMID:27780917
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	egfl6	IMP	ZFIN:ZDB-GENO-180523-5	Zfish	PMID:27780917
Biological Process	GO:0010811	positive regulation of cell-substrate adhesion	Egfl6	IDA		Mouse	PMID:18757743
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	egfl6	IMP	ZFIN:ZDB-MRPHLNO-151116-4	Zfish	PMID:27780917
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	egfl6	IGI	ZFIN:ZDB-GENE-060803-2	Zfish	PMID:27780917
Biological Process	GO:0008593	regulation of Notch signaling pathway	egfl6	IMP	ZFIN:ZDB-MRPHLNO-151116-5	Zfish	PMID:25952972
Biological Process	GO:1903670	regulation of sprouting angiogenesis	egfl6	IMP	ZFIN:ZDB-GENO-180523-5	Zfish	PMID:27780917

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern