Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EGLN1
  • Mouse genes Egln1
  • Rat genes Egln1
  • Zfish genes egln1a,egln1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Egln1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016706	2-oxoglutarate-dependent dioxygenase activity	EGLN1	IDA		Human	PMID:22955912
Molecular Function	GO:0019899	enzyme binding	Egln1	IPI	RGD:3281	Rat	PMID:22975349|RGD:8554232
Molecular Function	GO:0019899	enzyme binding	Egln1	IPI	UniProtKB:P14270	Rat	PMID:22975349|RGD:8554232
Molecular Function	GO:0008198	ferrous iron binding	EGLN1	IDA		Human	PMID:28594552
Molecular Function	GO:0031545	peptidyl-proline 4-dioxygenase activity	EGLN1	IDA		Human	PMID:11598268
Molecular Function	GO:0031543	peptidyl-proline dioxygenase activity	Egln1	IDA		Rat	PMID:18640395|RGD:6483450
Molecular Function	GO:0031543	peptidyl-proline dioxygenase activity	Egln1	IDA		Rat	PMID:20308610|RGD:6483365
Molecular Function	GO:0005515	protein binding	EGLN1	IPI	UniProtKB:Q13438	Human	PMID:15721254
Molecular Function	GO:0005515	protein binding	EGLN1	IPI	UniProtKB:Q16665	Human	PMID:16511565
Molecular Function	GO:0005515	protein binding	EGLN1	IPI	UniProtKB:Q14318	Human	PMID:17353276
Molecular Function	GO:0005515	protein binding	EGLN1	IPI	UniProtKB:Q16665	Human	PMID:17353276
Molecular Function	GO:0005515	protein binding	EGLN1	IPI	UniProtKB:Q99814	Human	PMID:17353276
Molecular Function	GO:0005515	protein binding	EGLN1	IPI	UniProtKB:Q99814	Human	PMID:19208626
Molecular Function	GO:0005515	protein binding	EGLN1	IPI	UniProtKB:Q16665	Human	PMID:20840591
Molecular Function	GO:0005515	protein binding	EGLN1	IPI	UniProtKB:Q9UGP4	Human	PMID:22286099
Molecular Function	GO:0005515	protein binding	EGLN1	IPI	UniProtKB:Q9WMX2:PRO_0000037551	Human	PMID:24169621
Molecular Function	GO:0005515	protein binding	EGLN1	IPI	UniProtKB:Q16665	Human	PMID:24681946
Molecular Function	GO:0005515	protein binding	EGLN1	IPI	UniProtKB:O75081	Human	PMID:25974097
Molecular Function	GO:0005515	protein binding	EGLN1	IPI	UniProtKB:Q16665	Human	PMID:25974097
Molecular Function	GO:0005515	protein binding	EGLN1	IPI	UniProtKB:Q99814	Human	PMID:30487161
Cellular Component	GO:0005737	cytoplasm	EGLN1	IDA		Human	PMID:12615973
Cellular Component	GO:0005829	cytosol	EGLN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Egln1	IDA		Rat	PMID:18640395|RGD:6483450
Cellular Component	GO:0098978	glutamatergic synapse	Egln1	IEP		Mouse	PMID:26972007
Cellular Component	GO:0098978	glutamatergic synapse	Egln1	IDA		Mouse	PMID:26972007
Cellular Component	GO:0098978	glutamatergic synapse	Egln1	IMP		Mouse	PMID:26972007
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	EGLN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0014069	postsynaptic density	Egln1	IDA		Mouse	PMID:26972007
Cellular Component	GO:0014069	postsynaptic density	Egln1	IEP		Mouse	PMID:26972007
Biological Process	GO:0055008	cardiac muscle tissue morphogenesis	Egln1	IMP	MGI:MGI:3690045	Mouse	PMID:16966370
Biological Process	GO:0060347	heart trabecula formation	Egln1	IMP	MGI:MGI:3690045	Mouse	PMID:16966370
Biological Process	GO:0006879	intracellular iron ion homeostasis	Egln1	IMP		Mouse	MGI:MGI:5752072|PMID:26818499
Biological Process	GO:0032364	intracellular oxygen homeostasis	EGLN1	IDA		Human	PMID:16956324
Biological Process	GO:0060711	labyrinthine layer development	Egln1	IMP	MGI:MGI:3690045	Mouse	PMID:16966370
Biological Process	GO:1905290	negative regulation of CAMKK-AMPK signaling cascade	Egln1	IMP		Rat	PMID:22128786|RGD:11340206
Biological Process	GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity	Egln1	IDA		Rat	PMID:22975349|RGD:8554232
Biological Process	GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity	Egln1	IMP		Rat	PMID:22975349|RGD:8554232
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	EGLN1	IDA		Human	PMID:16956324
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	Egln1	IDA		Rat	PMID:20308610|RGD:6483365
Biological Process	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	EGLN1	IDA		Human	PMID:11598268
Biological Process	GO:0043065	positive regulation of apoptotic process	Egln1	IDA		Rat	PMID:12675908|RGD:11252090
Biological Process	GO:1901216	positive regulation of neuron death	Egln1	IDA		Rat	PMID:10386996|RGD:11252089
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Egln1	IMP		Mouse	MGI:MGI:5752072|PMID:26818499
Biological Process	GO:0045765	regulation of angiogenesis	Egln1	IMP		Mouse	MGI:MGI:5306291|PMID:18500250
Biological Process	GO:0099159	regulation of modification of postsynaptic structure	Egln1	IDA		Mouse	PMID:26972007
Biological Process	GO:0099159	regulation of modification of postsynaptic structure	Egln1	IMP		Mouse	PMID:26972007
Biological Process	GO:0099159	regulation of modification of postsynaptic structure	Egln1	IEP		Mouse	PMID:26972007
Biological Process	GO:1901214	regulation of neuron death	Egln1	IMP		Mouse	MGI:MGI:5752072|PMID:26818499
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	Egln1	IDA		Mouse	PMID:26972007
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	Egln1	IMP		Mouse	PMID:26972007
Biological Process	GO:0140252	regulation protein catabolic process at postsynapse	Egln1	IEP		Mouse	PMID:26972007
Biological Process	GO:0001666	response to hypoxia	EGLN1	IDA		Human	PMID:16956324
Biological Process	GO:0001666	response to hypoxia	Egln1	IDA		Rat	PMID:12876291|RGD:727754
Biological Process	GO:0071731	response to nitric oxide	EGLN1	IDA		Human	PMID:21601578
Biological Process	GO:0060412	ventricular septum morphogenesis	Egln1	IMP	MGI:MGI:3690045	Mouse	PMID:16966370

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern