Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EGR1
  • Mouse genes Egr1
  • Rat genes Egr1
  • Zfish genes egr1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Egr1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	EGR1	IDA		Human	PMID:12560508
Molecular Function	GO:0003677	DNA binding	Egr1	IDA		Mouse	PMID:18323529
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	EGR1	IDA		Human	PMID:19307576
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	EGR1	IDA		Human	PMID:20018936
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Egr1	IMP		Mouse	MGI:MGI:3582090|PMID:15958557
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Egr1	IMP		Mouse	MGI:MGI:81719|PMID:8336701
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Egr1	IDA		Mouse	MGI:MGI:5009361|PMID:20018936
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Egr1	IDA		Rat	PMID:12021067|RGD:729311
Molecular Function	GO:0003700	DNA-binding transcription factor activity	EGR1	IDA		Human	PMID:12560508
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Egr1	IDA		Mouse	MGI:MGI:4399032|PMID:12689920
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Egr1	IMP		Rat	PMID:16849326|RGD:1626495
Molecular Function	GO:0003690	double-stranded DNA binding	Egr1	IDA		Rat	PMID:10837920|RGD:1626488
Molecular Function	GO:0010385	double-stranded methylated DNA binding	EGR1	IDA		Human	PMID:25258363
Molecular Function	GO:0044729	hemi-methylated DNA-binding	EGR1	IDA		Human	PMID:25258363
Molecular Function	GO:0035035	histone acetyltransferase binding	EGR1	IPI	UniProtKB:Q09472	Human	PMID:20018936
Molecular Function	GO:1990841	promoter-specific chromatin binding	EGR1	IDA		Human	PMID:20363028
Molecular Function	GO:1990841	promoter-specific chromatin binding	Egr1	IDA		Rat	PMID:22292946|RGD:10395298
Molecular Function	GO:0005515	protein binding	EGR1	IPI	UniProtKB:Q8N726	Human	PMID:19057511
Molecular Function	GO:0005515	protein binding	EGR1	IPI	UniProtKB:P35222	Human	PMID:21743491
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	EGR1	IDA		Human	PMID:19307576
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	EGR1	IDA		Human	PMID:20018936
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Egr1	IDA		Mouse	MGI:MGI:5009361|PMID:20018936
Molecular Function	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	Egr1	IDA		Rat	PMID:21451041|RGD:5131648
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	EGR1	IDA		Human	PMID:14979875
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Egr1	IMP		Mouse	MGI:MGI:81719|PMID:8336701
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Egr1	IDA		Mouse	MGI:MGI:3582090|PMID:15958557
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Egr1	IMP		Rat	PMID:14979875|RGD:10047233
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Egr1	IDA		Rat	PMID:21257751|RGD:5131851
Molecular Function	GO:0043565	sequence-specific DNA binding	EGR1	IDA		Human	PMID:1662794
Molecular Function	GO:0043565	sequence-specific DNA binding	EGR1	IDA		Human	PMID:25258363
Molecular Function	GO:0043565	sequence-specific DNA binding	Egr1	IDA		Rat	PMID:10837920|RGD:1626488
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	EGR1	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	EGR1	IDA		Human	PMID:18718911
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Egr1	IDA		Mouse	MGI:MGI:4834991|PMID:18281035
Molecular Function	GO:0008270	zinc ion binding	EGR1	IDA		Human	PMID:25258363
Cellular Component	GO:0000785	chromatin	EGR1	IDA		Human	PMID:19307576
Cellular Component	GO:0005737	cytoplasm	EGR1	IDA		Human	PMID:19057511
Cellular Component	GO:0005737	cytoplasm	EGR1	IDA		Human	PMID:20363028
Cellular Component	GO:0005737	cytoplasm	Egr1	IDA		Rat	PMID:21220915|RGD:5131857
Cellular Component	GO:0005737	cytoplasm	Egr1	IDA		Rat	PMID:8910451|RGD:8553929
Cellular Component	GO:0005654	nucleoplasm	EGR1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	EGR1	IDA		Human	PMID:19057511
Cellular Component	GO:0005634	nucleus	EGR1	IDA		Human	PMID:20018936
Cellular Component	GO:0005634	nucleus	EGR1	IDA		Human	PMID:20363028
Cellular Component	GO:0005634	nucleus	Egr1	IDA		Mouse	MGI:MGI:1928025|PMID:11100120
Cellular Component	GO:0005634	nucleus	Egr1	IDA		Mouse	MGI:MGI:4399032|PMID:12689920
Cellular Component	GO:0005634	nucleus	Egr1	IDA		Mouse	PMID:8668170
Cellular Component	GO:0005634	nucleus	Egr1	IDA		Mouse	PMID:18323529
Cellular Component	GO:0005634	nucleus	Egr1	IDA		Rat	PMID:10837920|RGD:1626488
Cellular Component	GO:0005634	nucleus	Egr1	IDA		Rat	PMID:14979875|RGD:10047233
Cellular Component	GO:0005634	nucleus	Egr1	IDA		Rat	PMID:1859855|RGD:11535086
Cellular Component	GO:0005634	nucleus	Egr1	IDA		Rat	PMID:8910451|RGD:8553929
Biological Process	GO:0030509	BMP signaling pathway	Egr1	IDA		Mouse	PMID:8769660
Biological Process	GO:0043010	camera-type eye development	egr1	IMP	ZFIN:ZDB-MRPHLNO-061229-2	Zfish	PMID:17110908
Biological Process	GO:0043010	camera-type eye development	egr1	IMP	ZFIN:ZDB-MRPHLNO-061229-1	Zfish	PMID:17110908
Biological Process	GO:0071236	cellular response to antibiotic	Egr1	IEP		Rat	PMID:21490970|RGD:5131646
Biological Process	GO:0071320	cellular response to cAMP	Egr1	IEP		Rat	PMID:12021067|RGD:729311
Biological Process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	Egr1	IEP		Rat	PMID:12021067|RGD:729311
Biological Process	GO:0071480	cellular response to gamma radiation	Egr1	IMP		Mouse	MGI:MGI:3830454|PMID:19057511
Biological Process	GO:0071371	cellular response to gonadotropin stimulus	Egr1	IEP		Rat	PMID:12021067|RGD:729311
Biological Process	GO:0071363	cellular response to growth factor stimulus	Egr1	IEP		Rat	PMID:21489990|RGD:5131647
Biological Process	GO:0071504	cellular response to heparin	Egr1	IDA		Rat	PMID:8910451|RGD:8553929
Biological Process	GO:0071455	cellular response to hyperoxia	Egr1	IEP		Rat	PMID:15734424|RGD:5131935
Biological Process	GO:0071456	cellular response to hypoxia	Egr1	IEP		Rat	PMID:21220915|RGD:5131857
Biological Process	GO:0032869	cellular response to insulin stimulus	Egr1	IEP		Rat	PMID:12970165|RGD:1601014
Biological Process	GO:0098759	cellular response to interleukin-8	EGR1	IDA		Human	PMID:20363028
Biological Process	GO:0071317	cellular response to isoquinoline alkaloid	Egr1	IEP		Rat	PMID:16448624|RGD:5131909
Biological Process	GO:0071260	cellular response to mechanical stimulus	Egr1	IEP		Rat	PMID:16998809|RGD:5131896
Biological Process	GO:0071506	cellular response to mycophenolic acid	Egr1	IDA		Rat	PMID:18723570|RGD:8553351
Biological Process	GO:0071310	cellular response to organic substance	Egr1	IDA		Mouse	PMID:21357543
Biological Process	GO:0071383	cellular response to steroid hormone stimulus	Egr1	IEP		Rat	PMID:21257751|RGD:5131851
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Egr1	IEP		Rat	PMID:21354245|RGD:5131879
Biological Process	GO:0032922	circadian regulation of gene expression	Egr1	IMP		Mouse	MGI:MGI:6258624|PMID:29138967
Biological Process	GO:0032922	circadian regulation of gene expression	Egr1	IMP		Mouse	MGI:MGI:6219065|PMID:26471974
Biological Process	GO:0007623	circadian rhythm	Egr1	IEP		Rat	PMID:21363938|RGD:5131656
Biological Process	GO:0060086	circadian temperature homeostasis	Egr1	IMP		Mouse	MGI:MGI:6258624|PMID:29138967
Biological Process	GO:0060059	embryonic retina morphogenesis in camera-type eye	egr1	IMP	ZFIN:ZDB-MRPHLNO-130327-8	Zfish	PMID:23405257
Biological Process	GO:0048703	embryonic viscerocranium morphogenesis	egr1	IMP	ZFIN:ZDB-MRPHLNO-130111-3	Zfish	PMID:23209659
Biological Process	GO:0044849	estrous cycle	Egr1	IMP		Mouse	MGI:MGI:82584|PMID:8703054
Biological Process	GO:0021782	glial cell development	egr1	IMP	ZFIN:ZDB-CRISPR-191009-33,ZFIN:ZDB-CRISPR-191009-34	Zfish	PMID:30924555
Biological Process	GO:0072110	glomerular mesangial cell proliferation	Egr1	IMP		Rat	PMID:18723570|RGD:8553351
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	EGR1	IMP		Human	PMID:20018936
Biological Process	GO:0007611	learning or memory	Egr1	IEP		Rat	PMID:12486186|RGD:727485
Biological Process	GO:0007611	learning or memory	Egr1	IMP		Rat	PMID:16930406|RGD:1626499
Biological Process	GO:0045475	locomotor rhythm	Egr1	IMP		Mouse	MGI:MGI:6258624|PMID:29138967
Biological Process	GO:0007616	long-term memory	Egr1	IMP		Rat	PMID:22906840|RGD:10395303
Biological Process	GO:0060291	long-term synaptic potentiation	Egr1	IEP		Rat	PMID:21425206|RGD:5131650
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	Egr1	IMP		Mouse	MGI:MGI:4834991|PMID:18281035
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Egr1	IDA		Mouse	PMID:16033766
Biological Process	GO:0048709	oligodendrocyte differentiation	Egr1	IEP		Rat	PMID:21490970|RGD:5131646
Biological Process	GO:0032722	positive regulation of chemokine production	Egr1	IMP		Mouse	MGI:MGI:1928025|PMID:11100120
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	EGR1	IDA		Human	PMID:12560508
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Egr1	IDA		Mouse	MGI:MGI:4399032|PMID:12689920
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Egr1	IMP		Mouse	MGI:MGI:6219065|PMID:26471974
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Egr1	IDA		Mouse	MGI:MGI:71467|PMID:7720589
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Egr1	IMP	MGI:MGI:2384433	Mouse	PMID:17202132
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Egr1	IMP		Rat	PMID:16849326|RGD:1626495
Biological Process	GO:0010628	positive regulation of gene expression	EGR1	IMP		Human	PMID:24244514
Biological Process	GO:0010628	positive regulation of gene expression	Egr1	IMP		Rat	PMID:21451041|RGD:5131648
Biological Process	GO:0072303	positive regulation of glomerular metanephric mesangial cell proliferation	Egr1	IMP		Rat	PMID:8910451|RGD:8553929
Biological Process	GO:0046886	positive regulation of hormone biosynthetic process	Egr1	IMP		Mouse	MGI:MGI:82584|PMID:8703054
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Egr1	IMP		Mouse	MGI:MGI:1928025|PMID:11100120
Biological Process	GO:1902895	positive regulation of miRNA transcription	EGR1	IDA		Human	PMID:19307576
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Egr1	IMP		Rat	PMID:21451041|RGD:5131648
Biological Process	GO:1901216	positive regulation of neuron death	Egr1	IGI	ComplexPortal:CPX-1120|ComplexPortal:CPX-1134|UniProtKB:P05067:PRO_0000000092|UniProtKB:P05067:PRO_0000000093	Rat	PMID:23164821|RGD:12903240
Biological Process	GO:1901875	positive regulation of post-translational protein modification	EGR1	IMP		Human	PMID:20018936
Biological Process	GO:0014911	positive regulation of smooth muscle cell migration	Egr1	IMP		Rat	PMID:23973488|RGD:10395311
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Egr1	IMP		Rat	PMID:23973488|RGD:10395311
Biological Process	GO:1902949	positive regulation of tau-protein kinase activity	Egr1	IGI	ComplexPortal:CPX-1120|ComplexPortal:CPX-1134|UniProtKB:P05067:PRO_0000000092|UniProtKB:P05067:PRO_0000000093	Rat	PMID:23164821|RGD:12903240
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	EGR1	IGI	UniProtKB:O95644	Human	PMID:14979875
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	EGR1	IGI	UniProtKB:P08047	Human	PMID:14979875
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	EGR1	IMP		Human	PMID:14979875
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	EGR1	IDA		Human	PMID:19057511
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	EGR1	IMP		Human	PMID:20018936
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	EGR1	IDA		Human	PMID:26089202
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Egr1	IMP		Mouse	MGI:MGI:1928025|PMID:11100120
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Egr1	IMP		Mouse	MGI:MGI:81719|PMID:8336701
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Egr1	IMP		Mouse	MGI:MGI:82584|PMID:8703054
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Egr1	IDA		Mouse	MGI:MGI:5009361|PMID:20018936
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Egr1	IDA		Rat	PMID:12021067|RGD:729311
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Egr1	IMP		Rat	PMID:16849326|RGD:1626495
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Egr1	IMP		Rat	PMID:21354245|RGD:5131879
Biological Process	GO:0042981	regulation of apoptotic process	Egr1	IMP		Mouse	PMID:23277542
Biological Process	GO:0006355	regulation of DNA-templated transcription	Egr1	IMP	MGI:MGI:2384433	Mouse	PMID:12165491
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity	Egr1	IMP		Rat	PMID:16930406|RGD:1626499
Biological Process	GO:2000182	regulation of progesterone biosynthetic process	Egr1	IMP		Mouse	MGI:MGI:82584|PMID:8703054
Biological Process	GO:0033233	regulation of protein sumoylation	EGR1	IDA		Human	PMID:19057511
Biological Process	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	Egr1	IDA		Mouse	PMID:18323529
Biological Process	GO:0001975	response to amphetamine	Egr1	IEP		Rat	PMID:21229349|RGD:5131852
Biological Process	GO:0034465	response to carbon monoxide	Egr1	IEP		Rat	PMID:16551742|RGD:5131903
Biological Process	GO:0042220	response to cocaine	Egr1	IEP		Rat	PMID:21334415|RGD:5131659
Biological Process	GO:0051602	response to electrical stimulus	Egr1	IEP		Rat	PMID:21334415|RGD:5131659
Biological Process	GO:0045471	response to ethanol	Egr1	IEP		Rat	PMID:11751152|RGD:70589
Biological Process	GO:0032354	response to follicle-stimulating hormone	Egr1	IEP		Rat	PMID:12554779|RGD:5131955
Biological Process	GO:0009749	response to glucose	Egr1	IDA		Mouse	MGI:MGI:4399032|PMID:12689920
Biological Process	GO:0034698	response to gonadotropin	Egr1	IEP		Rat	PMID:12554779|RGD:5131955
Biological Process	GO:0001666	response to hypoxia	Egr1	IMP		Mouse	MGI:MGI:1928025|PMID:11100120
Biological Process	GO:0032868	response to insulin	Egr1	IDA		Mouse	MGI:MGI:4399032|PMID:12689920
Biological Process	GO:0002931	response to ischemia	Egr1	IMP		Mouse	MGI:MGI:1928025|PMID:11100120
Biological Process	GO:0002931	response to ischemia	Egr1	IDA		Rat	PMID:1859855|RGD:11535086
Biological Process	GO:0071873	response to norepinephrine	Egr1	IEP		Rat	PMID:7905536|RGD:5131653
Biological Process	GO:0031667	response to nutrient levels	Egr1	IEP		Rat	PMID:21430247|RGD:5131649
Biological Process	GO:0009410	response to xenobiotic stimulus	Egr1	IEP		Rat	PMID:7905536|RGD:5131653
Biological Process	GO:0060041	retina development in camera-type eye	egr1	IMP	ZFIN:ZDB-CRISPR-191009-33,ZFIN:ZDB-CRISPR-191009-34	Zfish	PMID:30924555
Biological Process	GO:0035914	skeletal muscle cell differentiation	Egr1	IMP		Mouse	PMID:22147266
Biological Process	GO:0030217	T cell differentiation	Egr1	IMP	MGI:MGI:2384433	Mouse	PMID:12165491
Biological Process	GO:0042060	wound healing	Egr1	IEP		Rat	PMID:22918836|RGD:10395313

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern