Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Egr2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes EGR2
- Mouse genes Egr2
- Rat genes Egr2
- Zfish genes egr2a,egr2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Egr2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Egr2	IDA		Mouse	MGI:MGI:3768327\|PMID:17938205
Molecular Function	GO:0003677	DNA binding	Egr2	IDA		Mouse	PMID:8093858
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	EGR2	IDA		Human	PMID:12687019
Molecular Function	GO:0003700	DNA-binding transcription factor activity	EGR2	IDA		Human	PMID:14532282
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Egr2	IDA		Mouse	MGI:MGI:1331140\|PMID:10068633
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Egr2	IDA		Mouse	MGI:MGI:3768327\|PMID:17938205
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Egr2	IMP	MGI:MGI:1931056	Mouse	PMID:10704452
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Egr2	IDA		Mouse	PMID:8093858
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	EGR2	IDA		Human	PMID:17717711
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Egr2	IDA		Mouse	MGI:MGI:6393085\|PMID:31852952
Molecular Function	GO:0071837	HMG box domain binding	Egr2	IPI	UniProtKB:O55170	Rat	PMID:16582099\|RGD:6892704
Molecular Function	GO:0071837	HMG box domain binding	Egr2	IPI	UniProtKB:Q04886	Rat	PMID:16582099\|RGD:6892704
Molecular Function	GO:0071837	HMG box domain binding	Egr2	IPI	UniProtKB:Q05066	Rat	PMID:16582099\|RGD:6892704
Molecular Function	GO:0005515	protein binding	EGR2	IPI	UniProtKB:P51610	Human	PMID:14532282
Molecular Function	GO:0005515	protein binding	EGR2	IPI	UniProtKB:P46937	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Egr2	IPI	UniProtKB:P63280	Mouse	MGI:MGI:5508720\|PMID:21836637
Molecular Function	GO:0005515	protein binding	Egr2	IPI	UniProtKB:O70456\|UniProtKB:P97769	Mouse	MGI:MGI:3768327\|PMID:17938205
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	EGR2	IDA		Human	PMID:12687019
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Egr2	IDA		Mouse	PMID:8895582
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Egr2	IPI	UniProtKB:Q60793	Mouse	MGI:MGI:4887558\|PMID:18396140
Molecular Function	GO:0043565	sequence-specific DNA binding	EGR2	IDA		Human	PMID:17717711
Molecular Function	GO:0043565	sequence-specific DNA binding	Egr2	IDA		Mouse	MGI:MGI:52248\|PMID:8093858
Molecular Function	GO:0043565	sequence-specific DNA binding	Egr2	IDA		Mouse	MGI:MGI:6393337\|PMID:11823429
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	EGR2	IDA		Human	PMID:28473536
Molecular Function	GO:0061665	SUMO ligase activity	Egr2	IDA		Mouse	MGI:MGI:5508720\|PMID:21836637
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Egr2	IDA		Mouse	MGI:MGI:3768327\|PMID:17938205
Molecular Function	GO:0031625	ubiquitin protein ligase binding	EGR2	IPI	UniProtKB:O00308	Human	PMID:19651900
Cellular Component	GO:0005737	cytoplasm	Egr2	IDA		Mouse	MGI:MGI:3768327\|PMID:17938205
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	EGR2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	EGR2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Egr2	IDA		Mouse	MGI:MGI:3768327\|PMID:17938205
Cellular Component	GO:0005634	nucleus	Egr2	IDA		Mouse	PMID:15282162
Biological Process	GO:0035904	aorta development	Egr2	IMP		Mouse	PMID:25344368
Biological Process	GO:0035284	brain segmentation	Egr2	IMP	MGI:MGI:1857507	Mouse	PMID:7903221
Biological Process	GO:0071310	cellular response to organic substance	Egr2	IDA		Mouse	PMID:21357543
Biological Process	GO:0048568	embryonic organ development	egr2b	IMP	ZFIN:ZDB-MRPHLNO-110325-3	Zfish	PMID:21360790
Biological Process	GO:0021612	facial nerve structural organization	Egr2	IMP		Mouse	MGI:MGI:69122\|PMID:7935840
Biological Process	GO:0021612	facial nerve structural organization	Egr2	IMP		Mouse	MGI:MGI:1331140\|PMID:10068633
Biological Process	GO:0021612	facial nerve structural organization	Egr2	IGI	MGI:MGI:96170	Mouse	PMID:9806922
Biological Process	GO:0045444	fat cell differentiation	Egr2	IMP		Mouse	MGI:MGI:4887558\|PMID:18396140
Biological Process	GO:0045444	fat cell differentiation	Egr2	IMP		Mouse	MGI:MGI:3770184\|PMID:16054051
Biological Process	GO:0010467	gene expression	Egr2	IMP		Mouse	PMID:26941017
Biological Process	GO:0010467	gene expression	Egr2	IMP		Mouse	PMID:25344368
Biological Process	GO:0021575	hindbrain morphogenesis	egr2b	IMP	ZFIN:ZDB-GENO-130513-3	Zfish	PMID:23299976
Biological Process	GO:0007611	learning or memory	Egr2	IEP		Rat	PMID:8619872\|RGD:728620
Biological Process	GO:0008045	motor neuron axon guidance	Egr2	IGI	MGI:MGI:96170	Mouse	PMID:9806922
Biological Process	GO:0042552	myelination	Egr2	IMP	MGI:MGI:1931056,MGI:MGI:2183227	Mouse	PMID:20427655
Biological Process	GO:0042552	myelination	Egr2	IMP	MGI:MGI:2651549,MGI:MGI:3052515	Mouse	PMID:20427655
Biological Process	GO:0042552	myelination	Egr2	IMP	MGI:MGI:3574072	Mouse	PMID:16136673
Biological Process	GO:0042552	myelination	Egr2	IMP	MGI:MGI:1931056	Mouse	PMID:10704452
Biological Process	GO:0048932	myelination of posterior lateral line nerve axons	egr2b	IMP	ZFIN:ZDB-GENO-090917-4	Zfish	PMID:19745155
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Egr2	IDA		Mouse	MGI:MGI:3768327\|PMID:17938205
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Egr2	IDA		Mouse	MGI:MGI:6393337\|PMID:11823429
Biological Process	GO:0031643	positive regulation of myelination	Egr2	IMP		Mouse	MGI:MGI:69122\|PMID:7935840
Biological Process	GO:0014040	positive regulation of Schwann cell differentiation	Egr2	IMP		Mouse	MGI:MGI:1331140\|PMID:10068633
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	EGR2	IDA		Human	PMID:12687019
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	EGR2	IDA		Human	PMID:17717711
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Egr2	IDA		Mouse	MGI:MGI:4887558\|PMID:18396140
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Egr2	IDA		Mouse	PMID:8093858
Biological Process	GO:0006611	protein export from nucleus	Egr2	IDA		Mouse	MGI:MGI:3768327\|PMID:17938205
Biological Process	GO:0016925	protein sumoylation	Egr2	IDA		Mouse	MGI:MGI:5508720\|PMID:21836637
Biological Process	GO:0006355	regulation of DNA-templated transcription	Egr2	IMP	MGI:MGI:1931056	Mouse	PMID:10704452
Biological Process	GO:0006355	regulation of DNA-templated transcription	Egr2	IMP	MGI:MGI:3574072	Mouse	PMID:16136673
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity	Egr2	IEP		Rat	PMID:8619872\|RGD:728620
Biological Process	GO:0030278	regulation of ossification	Egr2	IMP	MGI:MGI:1857507	Mouse	PMID:8565822
Biological Process	GO:0032868	response to insulin	Egr2	IMP		Rat	PMID:12970165\|RGD:1601014
Biological Process	GO:0021569	rhombomere 3 development	Egr2	IGI	MGI:MGI:96170	Mouse	PMID:9806922
Biological Process	GO:0021660	rhombomere 3 formation	Egr2	IMP	MGI:MGI:1857507	Mouse	PMID:7903221
Biological Process	GO:0021659	rhombomere 3 structural organization	Egr2	IDA		Mouse	MGI:MGI:52248\|PMID:8093858
Biological Process	GO:0021666	rhombomere 5 formation	Egr2	IMP	MGI:MGI:1857507	Mouse	PMID:7903221
Biological Process	GO:0021665	rhombomere 5 structural organization	Egr2	IMP		Mouse	MGI:MGI:6393337\|PMID:11823429
Biological Process	GO:0021665	rhombomere 5 structural organization	Egr2	IDA		Mouse	MGI:MGI:52248\|PMID:8093858
Biological Process	GO:0021654	rhombomere boundary formation	egr2b	IMP	ZFIN:ZDB-GENO-020117-1	Zfish	PMID:11923201
Biological Process	GO:0007622	rhythmic behavior	Egr2	IDA		Mouse	PMID:8893031
Biological Process	GO:0007622	rhythmic behavior	Egr2	IMP	MGI:MGI:1857507	Mouse	PMID:8893031
Biological Process	GO:0014037	Schwann cell differentiation	Egr2	IMP		Mouse	MGI:MGI:69122\|PMID:7935840
Biological Process	GO:0014037	Schwann cell differentiation	Egr2	IMP	MGI:MGI:3574072	Mouse	PMID:16136673
Biological Process	GO:0014037	Schwann cell differentiation	Egr2	IMP		Mouse	PMID:20427655
Biological Process	GO:0035914	skeletal muscle cell differentiation	Egr2	IMP		Mouse	MGI:MGI:3695113\|PMID:11509834
Biological Process	GO:0035914	skeletal muscle cell differentiation	Egr2	IMP		Mouse	PMID:22147266

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.