Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EHD4
  • Mouse genes Ehd4
  • Rat genes Ehd4
  • Zfish genes ehd4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ehd4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	EHD4	HDA		Human	PMID:25468996
Molecular Function	GO:0005515	protein binding	EHD4	IPI	UniProtKB:Q9H4M9	Human	PMID:17233914
Molecular Function	GO:0005515	protein binding	EHD4	IPI	UniProtKB:Q9NZN3	Human	PMID:17233914
Molecular Function	GO:0005515	protein binding	EHD4	IPI	UniProtKB:Q9NZN4	Human	PMID:17233914
Molecular Function	GO:0005515	protein binding	Ehd4	IPI	UniProtKB:Q9QY17|UniProtKB:Q9Z2P6	Mouse	MGI:MGI:3808112|PMID:15371016
Molecular Function	GO:0005515	protein binding	Ehd4	IPI	PR:Q8C8R3	Mouse	PMID:20489164
Cellular Component	GO:0005783	endoplasmic reticulum	EHD4	IDA		Human	GO_REF:0000054
Cellular Component	GO:0070062	extracellular exosome	EHD4	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	EHD4	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	EHD4	HDA		Human	PMID:23533145
Cellular Component	GO:0016020	membrane	EHD4	HDA		Human	PMID:19946888
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Ehd4	IDA		Mouse	PMID:20489164
Cellular Component	GO:0005886	plasma membrane	Ehd4	IDA		Rat	PMID:12011113|RGD:632501
Cellular Component	GO:0055038	recycling endosome membrane	EHD4	IDA		Human	PMID:17233914
Biological Process	GO:0071363	cellular response to growth factor stimulus	Ehd4	IDA		Rat	PMID:12011113|RGD:632501
Biological Process	GO:0032456	endocytic recycling	EHD4	IGI	UniProtKB:G5ECC3,UniProtKB:G5EEU7	Human	PMID:17233914
Biological Process	GO:0006907	pinocytosis	Ehd4	IMP		Rat	PMID:12011113|RGD:632501
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Ehd4	IMP		Rat	PMID:12011113|RGD:632501
Biological Process	GO:0051260	protein homooligomerization	EHD4	IPI	UniProtKB:Q9H223	Human	PMID:17233914
Biological Process	GO:0030100	regulation of endocytosis	Ehd4	IMP		Rat	PMID:12011113|RGD:632501

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern