Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EIF2AK1
  • Mouse genes Eif2ak1
  • Rat genes Eif2ak1
  • Zfish genes eif2ak1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eif2ak1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	EIF2AK1	IDA		Human	PMID:11036079
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	EIF2AK1	IDA		Human	PMID:32132706
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	EIF2AK1	IDA		Human	PMID:32132707
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	Eif2ak1	IDA		Rat	PMID:7908290|RGD:70728
Molecular Function	GO:0020037	heme binding	Eif2ak1	IDA		Mouse	MGI:MGI:3687787|PMID:10671563
Molecular Function	GO:0005515	protein binding	EIF2AK1	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	EIF2AK1	IPI	UniProtKB:P11142	Human	PMID:29568061
Molecular Function	GO:0005515	protein binding	EIF2AK1	IPI	UniProtKB:P11142	Human	PMID:31273097
Molecular Function	GO:0005515	protein binding	EIF2AK1	IPI	UniProtKB:Q14154:PRO_0000450308	Human	PMID:32132706
Molecular Function	GO:0005515	protein binding	EIF2AK1	IPI	UniProtKB:Q14154:PRO_0000450308	Human	PMID:32132707
Molecular Function	GO:0005515	protein binding	EIF2AK1	IPI	UniProtKB:P08238	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Eif2ak1	IPI	UniProtKB:Q6ZWX6	Mouse	MGI:MGI:5508731|PMID:21223507
Molecular Function	GO:0042803	protein homodimerization activity	Eif2ak1	IPI	UniProtKB:Q9Z2R9	Mouse	MGI:MGI:3688058|PMID:11560503
Molecular Function	GO:0004672	protein kinase activity	Eif2ak1	IMP	MGI:MGI:2679454	Mouse	PMID:11726526
Cellular Component	GO:0005737	cytoplasm	Eif2ak1	IDA		Mouse	MGI:MGI:3687799|PMID:11050009
Cellular Component	GO:0005737	cytoplasm	Eif2ak1	IDA		Mouse	PMID:17932563
Biological Process	GO:0002526	acute inflammatory response	Eif2ak1	IMP	MGI:MGI:2679454	Mouse	PMID:17932563
Biological Process	GO:0051649	establishment of localization in cell	Eif2ak1	IMP	MGI:MGI:2679454	Mouse	PMID:17932563
Biological Process	GO:0140468	HRI-mediated signaling	EIF2AK1	IDA		Human	PMID:32132707
Biological Process	GO:0140467	integrated stress response signaling	EIF2AK1	IDA		Human	PMID:32132707
Biological Process	GO:0030225	macrophage differentiation	Eif2ak1	IMP	MGI:MGI:2679454	Mouse	PMID:17932563
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Eif2ak1	IMP	MGI:MGI:2679454	Mouse	PMID:17932563
Biological Process	GO:0008285	negative regulation of cell population proliferation	Eif2ak1	IDA		Mouse	MGI:MGI:3687799|PMID:11050009
Biological Process	GO:0046986	negative regulation of hemoglobin biosynthetic process	Eif2ak1	IDA		Mouse	MGI:MGI:3687799|PMID:11050009
Biological Process	GO:0006909	phagocytosis	Eif2ak1	IMP	MGI:MGI:2679454	Mouse	PMID:17932563
Biological Process	GO:0046777	protein autophosphorylation	Eif2ak1	IEP		Mouse	MGI:MGI:3688058|PMID:11560503
Biological Process	GO:0046501	protoporphyrinogen IX metabolic process	Eif2ak1	IGI	MGI:MGI:95513	Mouse	PMID:15931390
Biological Process	GO:0046501	protoporphyrinogen IX metabolic process	Eif2ak1	IGI	MGI:MGI:1353448	Mouse	PMID:15931390
Biological Process	GO:0010999	regulation of eIF2 alpha phosphorylation by heme	Eif2ak1	IGI	MGI:MGI:1353448	Mouse	PMID:15931390
Biological Process	GO:0010999	regulation of eIF2 alpha phosphorylation by heme	Eif2ak1	IGI	MGI:MGI:95513	Mouse	PMID:15931390
Biological Process	GO:0046984	regulation of hemoglobin biosynthetic process	Eif2ak1	IGI	MGI:MGI:1353448	Mouse	PMID:15931390
Biological Process	GO:0046984	regulation of hemoglobin biosynthetic process	Eif2ak1	IGI	MGI:MGI:95513	Mouse	PMID:15931390
Biological Process	GO:0006417	regulation of translation	Eif2ak1	IMP	MGI:MGI:2679454	Mouse	PMID:11726526
Biological Process	GO:1990641	response to iron ion starvation	EIF2AK1	IDA		Human	PMID:11036079

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern