Source |
Alliance of Genome Resources |
Category | ID | Classification term | Gene | Evidence | Inferred from | Organism | Reference |
---|---|---|---|---|---|---|---|
Molecular Function | GO:0003725 | double-stranded RNA binding | EIF2AK2 | IDA | Human | PMID:21266579 | |
Molecular Function | GO:0003725 | double-stranded RNA binding | Eif2ak2 | IDA | Mouse | PMID:21703541 | |
Molecular Function | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity | EIF2AK2 | IMP | Human | PMID:25329545 | |
Molecular Function | GO:0042802 | identical protein binding | EIF2AK2 | IPI | UniProtKB:P19525 | Human | PMID:16373505 |
Molecular Function | GO:0016301 | kinase activity | EIF2AK2 | IDA | Human | PMID:21123651 | |
Molecular Function | GO:0140677 | molecular function activator activity | EIF2AK2 | IDA | Human | PMID:21123651 | |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P27958:PRO_0000037570 | Human | PMID:10390359 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P27958:PRO_0000037576 | Human | PMID:10488152 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q2HR71 | Human | PMID:11160738 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:O92972:PRO_0000278746 | Human | PMID:11773402 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P04487 | Human | PMID:11836380 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P27958:PRO_0000037570 | Human | PMID:12610133 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P06748 | Human | PMID:12882984 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:O00463 | Human | PMID:15121867 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q12933 | Human | PMID:15121867 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q9Y4K3 | Human | PMID:15121867 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P52564 | Human | PMID:15229216 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P05198 | Human | PMID:16288713 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:O75569-1 | Human | PMID:16785445 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P06748 | Human | PMID:16957780 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q9NX74 | Human | PMID:18096616 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P55265 | Human | PMID:18362360 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P16333 | Human | PMID:18835251 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P05198 | Human | PMID:18971339 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P20639 | Human | PMID:18971339 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P06493 | Human | PMID:20395957 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:O75569 | Human | PMID:21903422 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P56537 | Human | PMID:21903422 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q08211 | Human | PMID:21903422 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q15633 | Human | PMID:21903422 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q6P2E9 | Human | PMID:21903422 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q7L2E3 | Human | PMID:21903422 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q8IY81 | Human | PMID:21903422 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q96C10 | Human | PMID:21903422 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q9H0E2 | Human | PMID:21903422 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q9HCE1 | Human | PMID:21903422 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q9NUL3 | Human | PMID:21903422 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q9UL40 | Human | PMID:21903422 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q9UPY3 | Human | PMID:21903422 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:O14862 | Human | PMID:22801494 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q96P20 | Human | PMID:22801494 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q9C000 | Human | PMID:22801494 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q9NPP4 | Human | PMID:22801494 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:O75569 | Human | PMID:23455922 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q7L2E3 | Human | PMID:23455922 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:O75569 | Human | PMID:32296183 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P78563-4 | Human | PMID:32296183 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:O75569 | Human | PMID:32707033 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q7L2E3 | Human | PMID:32707033 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q8IY81 | Human | PMID:32707033 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q9HCE1 | Human | PMID:32707033 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q9NUL3 | Human | PMID:32707033 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q9UL40 | Human | PMID:32707033 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P0DTC9 | Human | PMID:34035218 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P0DTC9 | Human | PMID:34578187 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P0DTC9 | Human | PMID:34780058 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:Q27968 | Human | PMID:8576172 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P27958:PRO_0000037576 | Human | PMID:9143277 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P05198 | Human | PMID:9431994 |
Molecular Function | GO:0005515 | protein binding | EIF2AK2 | IPI | UniProtKB:P20639 | Human | PMID:9431994 |
Molecular Function | GO:0005515 | protein binding | Eif2ak2 | IPI | UniProtKB:Q8R4B8 | Mouse | MGI:MGI:5432942|PMID:22801494 |
Molecular Function | GO:0005515 | protein binding | Eif2ak2 | IPI | UniProtKB:P35569 | Mouse | MGI:MGI:4457466|PMID:20144759 |
Molecular Function | GO:0005515 | protein binding | Eif2ak2 | IPI | UniProtKB:Q99MU3 | Mouse | MGI:MGI:5447606|PMID:18362360 |
Molecular Function | GO:0005515 | protein binding | Eif2ak2 | IPI | UniProtKB:Q61937 | Mouse | MGI:MGI:5486564|PMID:12882984 |
Molecular Function | GO:0005515 | protein binding | Eif2ak2 | IPI | PR:Q9R0N0 | Mouse | PMID:7519779 |
Molecular Function | GO:0005515 | protein binding | Eif2ak2 | IPI | PR:Q9R0B7 | Mouse | PMID:10488071 |
Molecular Function | GO:0005515 | protein binding | Eif2ak2 | IPI | RGD:1306707 | Rat | PMID:17953670|RGD:2301732 |
Molecular Function | GO:0004672 | protein kinase activity | EIF2AK2 | IDA | Human | PMID:12882984 | |
Molecular Function | GO:0004672 | protein kinase activity | EIF2AK2 | IDA | Human | PMID:15229216 | |
Molecular Function | GO:0004672 | protein kinase activity | EIF2AK2 | IDA | Human | PMID:18835251 | |
Molecular Function | GO:0004672 | protein kinase activity | EIF2AK2 | IMP | Human | PMID:21123651 | |
Molecular Function | GO:0004672 | protein kinase activity | EIF2AK2 | IDA | Human | PMID:248628414 | |
Molecular Function | GO:0004672 | protein kinase activity | Eif2ak2 | IMP | Mouse | MGI:MGI:4867319|PMID:21123651 | |
Molecular Function | GO:0004672 | protein kinase activity | Eif2ak2 | IDA | Mouse | PMID:7519779 | |
Molecular Function | GO:0004672 | protein kinase activity | Eif2ak2 | IDA | Mouse | PMID:15545996 | |
Molecular Function | GO:0004672 | protein kinase activity | eif2ak2 | IDA | Zfish | PMID:18312693 | |
Molecular Function | GO:0003723 | RNA binding | EIF2AK2 | HDA | Human | PMID:22681889 | |
Cellular Component | GO:0005737 | cytoplasm | EIF2AK2 | IDA | Human | PMID:21123651 | |
Cellular Component | GO:0005737 | cytoplasm | EIF2AK2 | IDA | Human | PMID:15121867 | |
Cellular Component | GO:0005829 | cytosol | EIF2AK2 | IDA | Human | GO_REF:0000052 | |
Cellular Component | GO:0016020 | membrane | EIF2AK2 | HDA | Human | PMID:19946888 | |
Cellular Component | GO:0005634 | nucleus | Eif2ak2 | IDA | Rat | PMID:17953670|RGD:2301732 | |
Cellular Component | GO:0048471 | perinuclear region of cytoplasm | EIF2AK2 | IDA | Human | PMID:15121867 | |
Biological Process | GO:0140374 | antiviral innate immune response | EIF2AK2 | IDA | Human | PMID:21145228 | |
Biological Process | GO:0034198 | cellular response to amino acid starvation | EIF2AK2 | IMP | Human | PMID:25329545 | |
Biological Process | GO:0051607 | defense response to virus | EIF2AK2 | IEP | Human | PMID:32634389 | |
Biological Process | GO:0030968 | endoplasmic reticulum unfolded protein response | Eif2ak2 | IDA | Mouse | PMID:15542627 | |
Biological Process | GO:0043066 | negative regulation of apoptotic process | Eif2ak2 | IGI | MGI:MGI:1341830 | Mouse | PMID:15542627 |
Biological Process | GO:0033689 | negative regulation of osteoblast proliferation | EIF2AK2 | IMP | Human | PMID:16216244 | |
Biological Process | GO:0017148 | negative regulation of translation | EIF2AK2 | IMP | Human | PMID:12610133 | |
Biological Process | GO:0017148 | negative regulation of translation | EIF2AK2 | IDA | Human | PMID:12882984 | |
Biological Process | GO:0017148 | negative regulation of translation | EIF2AK2 | IMP | Human | PMID:19189853 | |
Biological Process | GO:0045071 | negative regulation of viral genome replication | EIF2AK2 | IMP | Human | PMID:19189853 | |
Biological Process | GO:0045071 | negative regulation of viral genome replication | EIF2AK2 | IMP | Human | PMID:19840259 | |
Biological Process | GO:0045071 | negative regulation of viral genome replication | Eif2ak2 | IMP | Mouse | MGI:MGI:5487533|PMID:20038207 | |
Biological Process | GO:0043065 | positive regulation of apoptotic process | Eif2ak2 | IMP | Rat | PMID:18535002|RGD:2301730 | |
Biological Process | GO:0032722 | positive regulation of chemokine production | Eif2ak2 | IMP | Mouse | MGI:MGI:5487533|PMID:20038207 | |
Biological Process | GO:0001819 | positive regulation of cytokine production | Eif2ak2 | IMP | Mouse | MGI:MGI:5487533|PMID:20038207 | |
Biological Process | GO:0043410 | positive regulation of MAPK cascade | EIF2AK2 | IMP | Human | PMID:15229216 | |
Biological Process | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | EIF2AK2 | IDA | Human | PMID:15121867 | |
Biological Process | GO:1901224 | positive regulation of NIK/NF-kappaB signaling | Eif2ak2 | IMP | Mouse | MGI:MGI:5487533|PMID:20038207 | |
Biological Process | GO:0032874 | positive regulation of stress-activated MAPK cascade | Eif2ak2 | IMP | Mouse | MGI:MGI:5487533|PMID:20038207 | |
Biological Process | GO:0046777 | protein autophosphorylation | EIF2AK2 | IMP | Human | PMID:16216244 | |
Biological Process | GO:0046777 | protein autophosphorylation | EIF2AK2 | IDA | Human | PMID:22801494 | |
Biological Process | GO:0046777 | protein autophosphorylation | Eif2ak2 | IDA | Mouse | MGI:MGI:5432942|PMID:22801494 | |
Biological Process | GO:0046777 | protein autophosphorylation | Eif2ak2 | IDA | Mouse | PMID:15542627 | |
Biological Process | GO:0046777 | protein autophosphorylation | Eif2ak2 | IDA | Mouse | PMID:7519779 | |
Biological Process | GO:0006468 | protein phosphorylation | EIF2AK2 | IDA | Human | PMID:19189853 | |
Biological Process | GO:0006468 | protein phosphorylation | Eif2ak2 | IDA | Mouse | PMID:15542627 | |
Biological Process | GO:0006468 | protein phosphorylation | Eif2ak2 | IDA | Mouse | PMID:7519779 | |
Biological Process | GO:1901532 | regulation of hematopoietic progenitor cell differentiation | Eif2ak2 | IMP | Mouse | MGI:MGI:5487705|PMID:23403623 | |
Biological Process | GO:1902036 | regulation of hematopoietic stem cell differentiation | Eif2ak2 | IMP | Mouse | MGI:MGI:5487705|PMID:23403623 | |
Biological Process | GO:1902033 | regulation of hematopoietic stem cell proliferation | Eif2ak2 | IMP | Mouse | MGI:MGI:5487705|PMID:23403623 | |
Biological Process | GO:1900225 | regulation of NLRP3 inflammasome complex assembly | Eif2ak2 | IMP | Mouse | MGI:MGI:5432942|PMID:22801494 | |
Biological Process | GO:0043330 | response to exogenous dsRNA | Eif2ak2 | IEP | Rat | PMID:15920723|RGD:2301737 | |
Biological Process | GO:0035455 | response to interferon-alpha | EIF2AK2 | IDA | Human | PMID:19840259 | |
Biological Process | GO:0032496 | response to lipopolysaccharide | Eif2ak2 | IMP | Rat | PMID:15630703|RGD:2301739 | |
Biological Process | GO:0009612 | response to mechanical stimulus | Eif2ak2 | IEP | Rat | PMID:15781241|RGD:2301738 | |
Biological Process | GO:0010033 | response to organic substance | Eif2ak2 | IEP | Rat | PMID:17761171|RGD:2301735 | |
Biological Process | GO:0009636 | response to toxic substance | Eif2ak2 | IMP | Rat | PMID:18535002|RGD:2301730 | |
Biological Process | GO:0009615 | response to virus | EIF2AK2 | IMP | Human | PMID:19189853 | |
Biological Process | GO:0033197 | response to vitamin E | Eif2ak2 | IPI | RGD:1306707 | Rat | PMID:17953670|RGD:2301732 |
Biological Process | GO:0006412 | translation | Eif2ak2 | IDA | Mouse | PMID:7519779 |
EXP Inferred from experiment |
IDA Inferred from direct assay |
IEP Inferred from expression pattern |
IGI Inferred from genetic interaction |
IMP Inferred from mutant phenotype |
IPI Inferred from physical interaction |
HTP Inferred from High Throughput Experiment |
HDA Inferred from High Throughput Direct Assay |
HMP Inferred from High Throughput Mutant Phenotype |
HGI Inferred from High Throughput Genetic Interaction |
HEP Inferred from High Throughput Expression Pattern |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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