Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EIF2AK2
  • Mouse genes Eif2ak2
  • Rat genes Eif2ak2
  • Zfish genes eif2ak2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eif2ak2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003725	double-stranded RNA binding	EIF2AK2	IDA		Human	PMID:21266579
Molecular Function	GO:0003725	double-stranded RNA binding	Eif2ak2	IDA		Mouse	PMID:21703541
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	EIF2AK2	IMP		Human	PMID:25329545
Molecular Function	GO:0042802	identical protein binding	EIF2AK2	IPI	UniProtKB:P19525	Human	PMID:16373505
Molecular Function	GO:0016301	kinase activity	EIF2AK2	IDA		Human	PMID:21123651
Molecular Function	GO:0140677	molecular function activator activity	EIF2AK2	IDA		Human	PMID:21123651
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P27958:PRO_0000037570	Human	PMID:10390359
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P27958:PRO_0000037576	Human	PMID:10488152
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q2HR71	Human	PMID:11160738
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:O92972:PRO_0000278746	Human	PMID:11773402
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P04487	Human	PMID:11836380
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P27958:PRO_0000037570	Human	PMID:12610133
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P06748	Human	PMID:12882984
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:O00463	Human	PMID:15121867
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q12933	Human	PMID:15121867
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q9Y4K3	Human	PMID:15121867
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P52564	Human	PMID:15229216
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P05198	Human	PMID:16288713
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:O75569-1	Human	PMID:16785445
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P06748	Human	PMID:16957780
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q9NX74	Human	PMID:18096616
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P55265	Human	PMID:18362360
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P16333	Human	PMID:18835251
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P05198	Human	PMID:18971339
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P20639	Human	PMID:18971339
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P06493	Human	PMID:20395957
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:O75569	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P56537	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q08211	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q15633	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q6P2E9	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q7L2E3	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q8IY81	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q96C10	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q9H0E2	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q9HCE1	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q9NUL3	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q9UL40	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q9UPY3	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:O14862	Human	PMID:22801494
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q96P20	Human	PMID:22801494
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q9C000	Human	PMID:22801494
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q9NPP4	Human	PMID:22801494
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:O75569	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q7L2E3	Human	PMID:23455922
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:O75569	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P78563-4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:O75569	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q7L2E3	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q8IY81	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q9HCE1	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q9NUL3	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q9UL40	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P0DTC9	Human	PMID:34035218
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P0DTC9	Human	PMID:34578187
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P0DTC9	Human	PMID:34780058
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:Q27968	Human	PMID:8576172
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P27958:PRO_0000037576	Human	PMID:9143277
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P05198	Human	PMID:9431994
Molecular Function	GO:0005515	protein binding	EIF2AK2	IPI	UniProtKB:P20639	Human	PMID:9431994
Molecular Function	GO:0005515	protein binding	Eif2ak2	IPI	UniProtKB:Q8R4B8	Mouse	MGI:MGI:5432942|PMID:22801494
Molecular Function	GO:0005515	protein binding	Eif2ak2	IPI	UniProtKB:P35569	Mouse	MGI:MGI:4457466|PMID:20144759
Molecular Function	GO:0005515	protein binding	Eif2ak2	IPI	UniProtKB:Q99MU3	Mouse	MGI:MGI:5447606|PMID:18362360
Molecular Function	GO:0005515	protein binding	Eif2ak2	IPI	UniProtKB:Q61937	Mouse	MGI:MGI:5486564|PMID:12882984
Molecular Function	GO:0005515	protein binding	Eif2ak2	IPI	PR:Q9R0N0	Mouse	PMID:7519779
Molecular Function	GO:0005515	protein binding	Eif2ak2	IPI	PR:Q9R0B7	Mouse	PMID:10488071
Molecular Function	GO:0005515	protein binding	Eif2ak2	IPI	RGD:1306707	Rat	PMID:17953670|RGD:2301732
Molecular Function	GO:0004672	protein kinase activity	EIF2AK2	IDA		Human	PMID:12882984
Molecular Function	GO:0004672	protein kinase activity	EIF2AK2	IDA		Human	PMID:15229216
Molecular Function	GO:0004672	protein kinase activity	EIF2AK2	IDA		Human	PMID:18835251
Molecular Function	GO:0004672	protein kinase activity	EIF2AK2	IMP		Human	PMID:21123651
Molecular Function	GO:0004672	protein kinase activity	EIF2AK2	IDA		Human	PMID:248628414
Molecular Function	GO:0004672	protein kinase activity	Eif2ak2	IMP		Mouse	MGI:MGI:4867319|PMID:21123651
Molecular Function	GO:0004672	protein kinase activity	Eif2ak2	IDA		Mouse	PMID:7519779
Molecular Function	GO:0004672	protein kinase activity	Eif2ak2	IDA		Mouse	PMID:15545996
Molecular Function	GO:0004672	protein kinase activity	eif2ak2	IDA		Zfish	PMID:18312693
Molecular Function	GO:0003723	RNA binding	EIF2AK2	HDA		Human	PMID:22681889
Cellular Component	GO:0005737	cytoplasm	EIF2AK2	IDA		Human	PMID:21123651
Cellular Component	GO:0005737	cytoplasm	EIF2AK2	IDA		Human	PMID:15121867
Cellular Component	GO:0005829	cytosol	EIF2AK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	EIF2AK2	HDA		Human	PMID:19946888
Cellular Component	GO:0005634	nucleus	Eif2ak2	IDA		Rat	PMID:17953670|RGD:2301732
Cellular Component	GO:0048471	perinuclear region of cytoplasm	EIF2AK2	IDA		Human	PMID:15121867
Biological Process	GO:0140374	antiviral innate immune response	EIF2AK2	IDA		Human	PMID:21145228
Biological Process	GO:0034198	cellular response to amino acid starvation	EIF2AK2	IMP		Human	PMID:25329545
Biological Process	GO:0051607	defense response to virus	EIF2AK2	IEP		Human	PMID:32634389
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Eif2ak2	IDA		Mouse	PMID:15542627
Biological Process	GO:0043066	negative regulation of apoptotic process	Eif2ak2	IGI	MGI:MGI:1341830	Mouse	PMID:15542627
Biological Process	GO:0033689	negative regulation of osteoblast proliferation	EIF2AK2	IMP		Human	PMID:16216244
Biological Process	GO:0017148	negative regulation of translation	EIF2AK2	IMP		Human	PMID:12610133
Biological Process	GO:0017148	negative regulation of translation	EIF2AK2	IDA		Human	PMID:12882984
Biological Process	GO:0017148	negative regulation of translation	EIF2AK2	IMP		Human	PMID:19189853
Biological Process	GO:0045071	negative regulation of viral genome replication	EIF2AK2	IMP		Human	PMID:19189853
Biological Process	GO:0045071	negative regulation of viral genome replication	EIF2AK2	IMP		Human	PMID:19840259
Biological Process	GO:0045071	negative regulation of viral genome replication	Eif2ak2	IMP		Mouse	MGI:MGI:5487533|PMID:20038207
Biological Process	GO:0043065	positive regulation of apoptotic process	Eif2ak2	IMP		Rat	PMID:18535002|RGD:2301730
Biological Process	GO:0032722	positive regulation of chemokine production	Eif2ak2	IMP		Mouse	MGI:MGI:5487533|PMID:20038207
Biological Process	GO:0001819	positive regulation of cytokine production	Eif2ak2	IMP		Mouse	MGI:MGI:5487533|PMID:20038207
Biological Process	GO:0043410	positive regulation of MAPK cascade	EIF2AK2	IMP		Human	PMID:15229216
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	EIF2AK2	IDA		Human	PMID:15121867
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	Eif2ak2	IMP		Mouse	MGI:MGI:5487533|PMID:20038207
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	Eif2ak2	IMP		Mouse	MGI:MGI:5487533|PMID:20038207
Biological Process	GO:0046777	protein autophosphorylation	EIF2AK2	IMP		Human	PMID:16216244
Biological Process	GO:0046777	protein autophosphorylation	EIF2AK2	IDA		Human	PMID:22801494
Biological Process	GO:0046777	protein autophosphorylation	Eif2ak2	IDA		Mouse	MGI:MGI:5432942|PMID:22801494
Biological Process	GO:0046777	protein autophosphorylation	Eif2ak2	IDA		Mouse	PMID:15542627
Biological Process	GO:0046777	protein autophosphorylation	Eif2ak2	IDA		Mouse	PMID:7519779
Biological Process	GO:0006468	protein phosphorylation	EIF2AK2	IDA		Human	PMID:19189853
Biological Process	GO:0006468	protein phosphorylation	Eif2ak2	IDA		Mouse	PMID:15542627
Biological Process	GO:0006468	protein phosphorylation	Eif2ak2	IDA		Mouse	PMID:7519779
Biological Process	GO:1901532	regulation of hematopoietic progenitor cell differentiation	Eif2ak2	IMP		Mouse	MGI:MGI:5487705|PMID:23403623
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	Eif2ak2	IMP		Mouse	MGI:MGI:5487705|PMID:23403623
Biological Process	GO:1902033	regulation of hematopoietic stem cell proliferation	Eif2ak2	IMP		Mouse	MGI:MGI:5487705|PMID:23403623
Biological Process	GO:1900225	regulation of NLRP3 inflammasome complex assembly	Eif2ak2	IMP		Mouse	MGI:MGI:5432942|PMID:22801494
Biological Process	GO:0043330	response to exogenous dsRNA	Eif2ak2	IEP		Rat	PMID:15920723|RGD:2301737
Biological Process	GO:0035455	response to interferon-alpha	EIF2AK2	IDA		Human	PMID:19840259
Biological Process	GO:0032496	response to lipopolysaccharide	Eif2ak2	IMP		Rat	PMID:15630703|RGD:2301739
Biological Process	GO:0009612	response to mechanical stimulus	Eif2ak2	IEP		Rat	PMID:15781241|RGD:2301738
Biological Process	GO:0010033	response to organic substance	Eif2ak2	IEP		Rat	PMID:17761171|RGD:2301735
Biological Process	GO:0009636	response to toxic substance	Eif2ak2	IMP		Rat	PMID:18535002|RGD:2301730
Biological Process	GO:0009615	response to virus	EIF2AK2	IMP		Human	PMID:19189853
Biological Process	GO:0033197	response to vitamin E	Eif2ak2	IPI	RGD:1306707	Rat	PMID:17953670|RGD:2301732
Biological Process	GO:0006412	translation	Eif2ak2	IDA		Mouse	PMID:7519779

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern