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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Eif2ak2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eif2ak2
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0003725double-stranded RNA bindingEIF2AK2IDAHumanPMID:21266579
Molecular FunctionGO:0003725double-stranded RNA bindingEif2ak2IDAMousePMID:21703541
Molecular FunctionGO:0004694eukaryotic translation initiation factor 2alpha kinase activityEIF2AK2IMPHumanPMID:25329545
Molecular FunctionGO:0042802identical protein bindingEIF2AK2IPIUniProtKB:P19525HumanPMID:16373505
Molecular FunctionGO:0016301kinase activityEIF2AK2IDAHumanPMID:21123651
Molecular FunctionGO:0140677molecular function activator activityEIF2AK2IDAHumanPMID:21123651
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P27958:PRO_0000037570HumanPMID:10390359
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P27958:PRO_0000037576HumanPMID:10488152
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q2HR71HumanPMID:11160738
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:O92972:PRO_0000278746HumanPMID:11773402
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P04487HumanPMID:11836380
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P27958:PRO_0000037570HumanPMID:12610133
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P06748HumanPMID:12882984
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:O00463HumanPMID:15121867
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q12933HumanPMID:15121867
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q9Y4K3HumanPMID:15121867
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P52564HumanPMID:15229216
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P05198HumanPMID:16288713
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:O75569-1HumanPMID:16785445
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P06748HumanPMID:16957780
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q9NX74HumanPMID:18096616
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P55265HumanPMID:18362360
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P16333HumanPMID:18835251
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P05198HumanPMID:18971339
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P20639HumanPMID:18971339
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P06493HumanPMID:20395957
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:O75569HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P56537HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q08211HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q15633HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q6P2E9HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q7L2E3HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q8IY81HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q96C10HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q9H0E2HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q9HCE1HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q9NUL3HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q9UL40HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q9UPY3HumanPMID:21903422
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:O14862HumanPMID:22801494
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q96P20HumanPMID:22801494
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q9C000HumanPMID:22801494
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q9NPP4HumanPMID:22801494
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:O75569HumanPMID:23455922
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q7L2E3HumanPMID:23455922
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:O75569HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P78563-4HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:O75569HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q7L2E3HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q8IY81HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q9HCE1HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q9NUL3HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q9UL40HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P0DTC9HumanPMID:34035218
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P0DTC9HumanPMID:34578187
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P0DTC9HumanPMID:34780058
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:Q27968HumanPMID:8576172
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P27958:PRO_0000037576HumanPMID:9143277
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P05198HumanPMID:9431994
Molecular FunctionGO:0005515protein bindingEIF2AK2IPIUniProtKB:P20639HumanPMID:9431994
Molecular FunctionGO:0005515protein bindingEif2ak2IPIUniProtKB:Q8R4B8MouseMGI:MGI:5432942|PMID:22801494
Molecular FunctionGO:0005515protein bindingEif2ak2IPIUniProtKB:P35569MouseMGI:MGI:4457466|PMID:20144759
Molecular FunctionGO:0005515protein bindingEif2ak2IPIUniProtKB:Q99MU3MouseMGI:MGI:5447606|PMID:18362360
Molecular FunctionGO:0005515protein bindingEif2ak2IPIUniProtKB:Q61937MouseMGI:MGI:5486564|PMID:12882984
Molecular FunctionGO:0005515protein bindingEif2ak2IPIPR:Q9R0N0MousePMID:7519779
Molecular FunctionGO:0005515protein bindingEif2ak2IPIPR:Q9R0B7MousePMID:10488071
Molecular FunctionGO:0005515protein bindingEif2ak2IPIRGD:1306707RatPMID:17953670|RGD:2301732
Molecular FunctionGO:0004672protein kinase activityEIF2AK2IDAHumanPMID:12882984
Molecular FunctionGO:0004672protein kinase activityEIF2AK2IDAHumanPMID:15229216
Molecular FunctionGO:0004672protein kinase activityEIF2AK2IDAHumanPMID:18835251
Molecular FunctionGO:0004672protein kinase activityEIF2AK2IMPHumanPMID:21123651
Molecular FunctionGO:0004672protein kinase activityEIF2AK2IDAHumanPMID:248628414
Molecular FunctionGO:0004672protein kinase activityEif2ak2IMPMouseMGI:MGI:4867319|PMID:21123651
Molecular FunctionGO:0004672protein kinase activityEif2ak2IDAMousePMID:7519779
Molecular FunctionGO:0004672protein kinase activityEif2ak2IDAMousePMID:15545996
Molecular FunctionGO:0004672protein kinase activityeif2ak2IDAZfishPMID:18312693
Molecular FunctionGO:0003723RNA bindingEIF2AK2HDAHumanPMID:22681889
Cellular ComponentGO:0005737cytoplasmEIF2AK2IDAHumanPMID:21123651
Cellular ComponentGO:0005737cytoplasmEIF2AK2IDAHumanPMID:15121867
Cellular ComponentGO:0005829cytosolEIF2AK2IDAHumanGO_REF:0000052
Cellular ComponentGO:0016020membraneEIF2AK2HDAHumanPMID:19946888
Cellular ComponentGO:0005634nucleusEif2ak2IDARatPMID:17953670|RGD:2301732
Cellular ComponentGO:0048471perinuclear region of cytoplasmEIF2AK2IDAHumanPMID:15121867
Biological ProcessGO:0140374antiviral innate immune responseEIF2AK2IDAHumanPMID:21145228
Biological ProcessGO:0034198cellular response to amino acid starvationEIF2AK2IMPHumanPMID:25329545
Biological ProcessGO:0051607defense response to virusEIF2AK2IEPHumanPMID:32634389
Biological ProcessGO:0030968endoplasmic reticulum unfolded protein responseEif2ak2IDAMousePMID:15542627
Biological ProcessGO:0043066negative regulation of apoptotic processEif2ak2IGIMGI:MGI:1341830MousePMID:15542627
Biological ProcessGO:0033689negative regulation of osteoblast proliferationEIF2AK2IMPHumanPMID:16216244
Biological ProcessGO:0017148negative regulation of translationEIF2AK2IMPHumanPMID:12610133
Biological ProcessGO:0017148negative regulation of translationEIF2AK2IDAHumanPMID:12882984
Biological ProcessGO:0017148negative regulation of translationEIF2AK2IMPHumanPMID:19189853
Biological ProcessGO:0045071negative regulation of viral genome replicationEIF2AK2IMPHumanPMID:19189853
Biological ProcessGO:0045071negative regulation of viral genome replicationEIF2AK2IMPHumanPMID:19840259
Biological ProcessGO:0045071negative regulation of viral genome replicationEif2ak2IMPMouseMGI:MGI:5487533|PMID:20038207
Biological ProcessGO:0043065positive regulation of apoptotic processEif2ak2IMPRatPMID:18535002|RGD:2301730
Biological ProcessGO:0032722positive regulation of chemokine productionEif2ak2IMPMouseMGI:MGI:5487533|PMID:20038207
Biological ProcessGO:0001819positive regulation of cytokine productionEif2ak2IMPMouseMGI:MGI:5487533|PMID:20038207
Biological ProcessGO:0043410positive regulation of MAPK cascadeEIF2AK2IMPHumanPMID:15229216
Biological ProcessGO:0051092positive regulation of NF-kappaB transcription factor activityEIF2AK2IDAHumanPMID:15121867
Biological ProcessGO:1901224positive regulation of NIK/NF-kappaB signalingEif2ak2IMPMouseMGI:MGI:5487533|PMID:20038207
Biological ProcessGO:0032874positive regulation of stress-activated MAPK cascadeEif2ak2IMPMouseMGI:MGI:5487533|PMID:20038207
Biological ProcessGO:0046777protein autophosphorylationEIF2AK2IMPHumanPMID:16216244
Biological ProcessGO:0046777protein autophosphorylationEIF2AK2IDAHumanPMID:22801494
Biological ProcessGO:0046777protein autophosphorylationEif2ak2IDAMouseMGI:MGI:5432942|PMID:22801494
Biological ProcessGO:0046777protein autophosphorylationEif2ak2IDAMousePMID:15542627
Biological ProcessGO:0046777protein autophosphorylationEif2ak2IDAMousePMID:7519779
Biological ProcessGO:0006468protein phosphorylationEIF2AK2IDAHumanPMID:19189853
Biological ProcessGO:0006468protein phosphorylationEif2ak2IDAMousePMID:15542627
Biological ProcessGO:0006468protein phosphorylationEif2ak2IDAMousePMID:7519779
Biological ProcessGO:1901532regulation of hematopoietic progenitor cell differentiationEif2ak2IMPMouseMGI:MGI:5487705|PMID:23403623
Biological ProcessGO:1902036regulation of hematopoietic stem cell differentiationEif2ak2IMPMouseMGI:MGI:5487705|PMID:23403623
Biological ProcessGO:1902033regulation of hematopoietic stem cell proliferationEif2ak2IMPMouseMGI:MGI:5487705|PMID:23403623
Biological ProcessGO:1900225regulation of NLRP3 inflammasome complex assemblyEif2ak2IMPMouseMGI:MGI:5432942|PMID:22801494
Biological ProcessGO:0043330response to exogenous dsRNAEif2ak2IEPRatPMID:15920723|RGD:2301737
Biological ProcessGO:0035455response to interferon-alphaEIF2AK2IDAHumanPMID:19840259
Biological ProcessGO:0032496response to lipopolysaccharideEif2ak2IMPRatPMID:15630703|RGD:2301739
Biological ProcessGO:0009612response to mechanical stimulusEif2ak2IEPRatPMID:15781241|RGD:2301738
Biological ProcessGO:0010033response to organic substanceEif2ak2IEPRatPMID:17761171|RGD:2301735
Biological ProcessGO:0009636response to toxic substanceEif2ak2IMPRatPMID:18535002|RGD:2301730
Biological ProcessGO:0009615response to virusEIF2AK2IMPHumanPMID:19189853
Biological ProcessGO:0033197response to vitamin EEif2ak2IPIRGD:1306707RatPMID:17953670|RGD:2301732
Biological ProcessGO:0006412translationEif2ak2IDAMousePMID:7519779

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory