Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EIF2AK4
  • Mouse genes Eif2ak4
  • Rat genes Eif2ak4
  • Zfish genes eif2ak4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eif2ak4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	EIF2AK4	IDA		Human	PMID:25329545
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	EIF2AK4	IMP		Human	PMID:25329545
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	Eif2ak4	IMP		Mouse	MGI:MGI:3770235|PMID:16054071
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	Eif2ak4	IMP		Mouse	MGI:MGI:3589053|PMID:16121183
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	Eif2ak4	IGI	UniProtKB:Q9Z2B5	Mouse	MGI:MGI:3722921|PMID:14729979
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	Eif2ak4	IDA		Mouse	MGI:MGI:5700304|PMID:16601681
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	Eif2ak4	IDA		Mouse	MGI:MGI:2149467|PMID:10655230
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	Eif2ak4	IDA		Mouse	MGI:MGI:1346365|PMID:10504407
Molecular Function	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity	Eif2ak4	IDA		Mouse	MGI:MGI:5700311|PMID:12176355
Molecular Function	GO:0005515	protein binding	Eif2ak4	IPI	UniProtKB:E9PVA8	Mouse	MGI:MGI:5576818|PMID:24333428
Molecular Function	GO:0005515	protein binding	Eif2ak4	IPI	UniProtKB:Q91YW3	Mouse	MGI:MGI:5617428|PMID:25329545
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Eif2ak4	IDA		Mouse	MGI:MGI:1346365|PMID:10504407
Molecular Function	GO:0000049	tRNA binding	Eif2ak4	IDA		Mouse	MGI:MGI:5700304|PMID:16601681
Cellular Component	GO:0005844	polysome	Eif2ak4	IDA		Mouse	MGI:MGI:5494763|PMID:23447528
Biological Process	GO:0034198	cellular response to amino acid starvation	EIF2AK4	IMP		Human	PMID:25329545
Biological Process	GO:0034198	cellular response to amino acid starvation	Eif2ak4	IDA		Mouse	MGI:MGI:5576818|PMID:24333428
Biological Process	GO:0034198	cellular response to amino acid starvation	Eif2ak4	IMP		Mouse	MGI:MGI:3722921|PMID:14729979
Biological Process	GO:0070417	cellular response to cold	EIF2AK4	IMP		Human	PMID:25329545
Biological Process	GO:1990253	cellular response to leucine starvation	Eif2ak4	IDA		Mouse	MGI:MGI:5494763|PMID:23447528
Biological Process	GO:0009267	cellular response to starvation	Eif2ak4	IDA		Mouse	PMID:15937339
Biological Process	GO:0034644	cellular response to UV	Eif2ak4	IDA		Mouse	MGI:MGI:5700311|PMID:12176355
Biological Process	GO:0036492	eiF2alpha phosphorylation in response to endoplasmic reticulum stress	EIF2AK4	IMP		Human	PMID:25329545
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	Eif2ak4	IMP	MGI:MGI:2387965	Mouse	PMID:16176978
Biological Process	GO:0140469	GCN2-mediated signaling	EIF2AK4	IDA		Human	PMID:25329545
Biological Process	GO:0140469	GCN2-mediated signaling	EIF2AK4	IMP		Human	PMID:26102367
Biological Process	GO:0140469	GCN2-mediated signaling	Eif2ak4	IMP		Mouse	MGI:MGI:3589053|PMID:16121183
Biological Process	GO:0140469	GCN2-mediated signaling	Eif2ak4	IDA		Mouse	MGI:MGI:2149467|PMID:10655230
Biological Process	GO:0140469	GCN2-mediated signaling	Eif2ak4	IMP		Mouse	MGI:MGI:5700278|PMID:26102367
Biological Process	GO:0140469	GCN2-mediated signaling	Eif2ak4	IMP		Mouse	MGI:MGI:3770235|PMID:16054071
Biological Process	GO:0140469	GCN2-mediated signaling	Eif2ak4	IMP		Mouse	MGI:MGI:3582244|PMID:11106749
Biological Process	GO:0007612	learning	Eif2ak4	IMP		Mouse	MGI:MGI:3589053|PMID:16121183
Biological Process	GO:0007616	long-term memory	Eif2ak4	IMP		Mouse	MGI:MGI:3589053|PMID:16121183
Biological Process	GO:0044828	negative regulation by host of viral genome replication	Eif2ak4	IDA		Mouse	MGI:MGI:5700304|PMID:16601681
Biological Process	GO:0032792	negative regulation of CREB transcription factor activity	Eif2ak4	IMP		Mouse	MGI:MGI:3589053|PMID:16121183
Biological Process	GO:0045665	negative regulation of neuron differentiation	Eif2ak4	IMP		Mouse	MGI:MGI:5494763|PMID:23447528
Biological Process	GO:0017148	negative regulation of translation	Eif2ak4	IGI	MGI:MGI:1341830	Mouse	PMID:16176978
Biological Process	GO:0045947	negative regulation of translational initiation	Eif2ak4	IDA		Mouse	MGI:MGI:5700304|PMID:16601681
Biological Process	GO:0032057	negative regulation of translational initiation in response to stress	Eif2ak4	IDA		Mouse	MGI:MGI:5700311|PMID:12176355
Biological Process	GO:1990138	neuron projection extension	Eif2ak4	IMP		Mouse	MGI:MGI:5494763|PMID:23447528
Biological Process	GO:0002821	positive regulation of adaptive immune response	Eif2ak4	IMP		Mouse	MGI:MGI:5544501|PMID:24310610
Biological Process	GO:0002230	positive regulation of defense response to virus by host	Eif2ak4	IDA		Mouse	MGI:MGI:5700304|PMID:16601681
Biological Process	GO:0010628	positive regulation of gene expression	Eif2ak4	IMP		Mouse	MGI:MGI:3722921|PMID:14729979
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	Eif2ak4	IMP		Mouse	MGI:MGI:3589053|PMID:16121183
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Eif2ak4	IMP		Rat	PMID:32209028|RGD:38549370
Biological Process	GO:0071264	positive regulation of translational initiation in response to starvation	Eif2ak4	IDA		Mouse	MGI:MGI:2149467|PMID:10655230
Biological Process	GO:0071264	positive regulation of translational initiation in response to starvation	Eif2ak4	IMP		Mouse	MGI:MGI:3589053|PMID:16121183
Biological Process	GO:0046777	protein autophosphorylation	Eif2ak4	IDA		Mouse	MGI:MGI:2149467|PMID:10655230
Biological Process	GO:0046777	protein autophosphorylation	Eif2ak4	IDA		Mouse	MGI:MGI:5700304|PMID:16601681
Biological Process	GO:0006468	protein phosphorylation	Eif2ak4	IMP		Mouse	MGI:MGI:3589053|PMID:16121183
Biological Process	GO:0006468	protein phosphorylation	Eif2ak4	IMP		Mouse	MGI:MGI:3770235|PMID:16054071
Biological Process	GO:0006468	protein phosphorylation	Eif2ak4	IDA		Mouse	MGI:MGI:1346365|PMID:10504407
Biological Process	GO:0006468	protein phosphorylation	Eif2ak4	IMP		Mouse	MGI:MGI:3582244|PMID:11106749
Biological Process	GO:0060259	regulation of feeding behavior	Eif2ak4	IMP		Mouse	MGI:MGI:3770235|PMID:16054071
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	EIF2AK4	IMP		Human	PMID:26102367
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	Eif2ak4	IDA		Mouse	MGI:MGI:5700304|PMID:16601681
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	Eif2ak4	IDA		Mouse	MGI:MGI:5700311|PMID:12176355
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	Eif2ak4	IMP		Mouse	MGI:MGI:5700278|PMID:26102367
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	Eif2ak4	IMP		Mouse	MGI:MGI:3589053|PMID:16121183
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	Eif2ak4	IGI	UniProtKB:Q9Z2B5	Mouse	MGI:MGI:3722921|PMID:14729979
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	Eif2ak4	IMP		Mouse	MGI:MGI:3582244|PMID:11106749
Biological Process	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	Eif2ak4	IDA		Mouse	MGI:MGI:2149467|PMID:10655230
Biological Process	GO:0043558	regulation of translational initiation in response to stress	Eif2ak4	IDA		Mouse	PMID:15937339
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Eif2ak4	IGI	UniProtKB:Q9Z2B5	Mouse	MGI:MGI:3722921|PMID:14729979
Biological Process	GO:0002286	T cell activation involved in immune response	Eif2ak4	IMP		Mouse	MGI:MGI:5544501|PMID:24310610
Biological Process	GO:0019081	viral translation	Eif2ak4	IDA		Mouse	MGI:MGI:5700304|PMID:16601681

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern