Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EIF2S1
  • Mouse genes Eif2s1
  • Rat genes Eif2s1
  • Zfish genes eif2s1a,eif2s1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eif2s1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	EIF2S1	IPI	UniProtKB:Q64350	Human	PMID:11500362
Molecular Function	GO:0005515	protein binding	EIF2S1	IPI	UniProtKB:P19525	Human	PMID:16288713
Molecular Function	GO:0005515	protein binding	EIF2S1	IPI	UniProtKB:P20042	Human	PMID:16288713
Molecular Function	GO:0005515	protein binding	EIF2S1	IPI	UniProtKB:P41091	Human	PMID:16288713
Molecular Function	GO:0005515	protein binding	EIF2S1	IPI	UniProtKB:Q9Z2B5	Human	PMID:16288713
Molecular Function	GO:0005515	protein binding	EIF2S1	IPI	UniProtKB:P20042	Human	PMID:16932749
Molecular Function	GO:0005515	protein binding	EIF2S1	IPI	UniProtKB:Q8NE71	Human	PMID:17894550
Molecular Function	GO:0005515	protein binding	EIF2S1	IPI	UniProtKB:Q8NE71-2	Human	PMID:17894550
Molecular Function	GO:0005515	protein binding	EIF2S1	IPI	UniProtKB:O00571	Human	PMID:18596238
Molecular Function	GO:0005515	protein binding	EIF2S1	IPI	UniProtKB:P19525	Human	PMID:18971339
Molecular Function	GO:0005515	protein binding	EIF2S1	IPI	UniProtKB:O00571	Human	PMID:22323517
Molecular Function	GO:0005515	protein binding	EIF2S1	IPI	UniProtKB:Q9Y4P3	Human	PMID:25393282
Molecular Function	GO:0005515	protein binding	EIF2S1	IPI	UniProtKB:P62136	Human	PMID:26095357
Molecular Function	GO:0005515	protein binding	EIF2S1	IPI	UniProtKB:P20042	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	EIF2S1	IPI	UniProtKB:P12814	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF2S1	IPI	UniProtKB:Q08AM6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF2S1	IPI	UniProtKB:Q9NVM4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF2S1	IPI	UniProtKB:P19525	Human	PMID:9431994
Molecular Function	GO:0005515	protein binding	Eif2s1	IPI	UniProtKB:Q9Z2R9	Mouse	MGI:MGI:5508731|PMID:21223507
Molecular Function	GO:0005515	protein binding	Eif2s1	IPI	PR:O08663	Mouse	PMID:15544353
Molecular Function	GO:0005515	protein binding	Eif2s1	IPI	RGD:735192|RGD:1561279	Rat	PMID:2450747|RGD:10395356
Molecular Function	GO:0005515	protein binding	Eif2s1	IPI	UniProtKB:P17074	Rat	PMID:3384085|RGD:8554720
Molecular Function	GO:0005515	protein binding	Eif2s1	IPI	UniProtKB:P49242	Rat	PMID:3384085|RGD:8554720
Molecular Function	GO:0005515	protein binding	Eif2s1	IPI	UniProtKB:P62850	Rat	PMID:3384085|RGD:8554720
Molecular Function	GO:0043022	ribosome binding	EIF2S1	IDA		Human	PMID:17894550
Molecular Function	GO:0003723	RNA binding	EIF2S1	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	EIF2S1	HDA		Human	PMID:22681889
Molecular Function	GO:0003743	translation initiation factor activity	EIF2S1	IDA		Human	PMID:16289705
Cellular Component	GO:0005737	cytoplasm	Eif2s1	IDA		Mouse	PMID:12388085
Cellular Component	GO:0005737	cytoplasm	Eif2s1	IDA		Rat	PMID:9397028|RGD:10395349
Cellular Component	GO:0010494	cytoplasmic stress granule	Eif2s1	IDA		Mouse	MGI:MGI:4820495|PMID:19861488
Cellular Component	GO:0005829	cytosol	EIF2S1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005850	eukaryotic translation initiation factor 2 complex	EIF2S1	IDA		Human	PMID:23063529
Cellular Component	GO:0005850	eukaryotic translation initiation factor 2 complex	Eif2s1	IDA		Rat	PMID:2450747|RGD:10395356
Cellular Component	GO:0005851	eukaryotic translation initiation factor 2B complex	EIF2S1	IDA		Human	PMID:11323413
Cellular Component	GO:0070062	extracellular exosome	EIF2S1	HDA		Human	PMID:20458337
Cellular Component	GO:0097451	glial limiting end-foot	Eif2s1	IDA		Rat	PMID:9397028|RGD:10395349
Cellular Component	GO:0016020	membrane	EIF2S1	HDA		Human	PMID:19946888
Cellular Component	GO:0005634	nucleus	Eif2s1	IDA		Mouse	PMID:12388085
Cellular Component	GO:0005634	nucleus	Eif2s1	IDA		Rat	PMID:9397028|RGD:10395349
Cellular Component	GO:0045202	synapse	Eif2s1	EXP		Mouse	PMID:25211037
Cellular Component	GO:0045202	synapse	Eif2s1	IDA		Mouse	PMID:25211037
Cellular Component	GO:0045202	synapse	Eif2s1	EXP		Mouse	PMID:16452087
Cellular Component	GO:0045202	synapse	Eif2s1	IDA		Mouse	PMID:16452087
Cellular Component	GO:0044207	translation initiation ternary complex	Eif2s1	IDA		Rat	PMID:2450747|RGD:10395356
Biological Process	GO:0034198	cellular response to amino acid starvation	Eif2s1	IDA		Mouse	MGI:MGI:3582244|PMID:11106749
Biological Process	GO:0034605	cellular response to heat	Eif2s1	IEP		Rat	PMID:3500171|RGD:10395357
Biological Process	GO:0034605	cellular response to heat	Eif2s1	IDA		Rat	PMID:7930798|RGD:10395354
Biological Process	GO:0034599	cellular response to oxidative stress	Eif2s1	IMP		Mouse	MGI:MGI:6148443|PMID:27430620
Biological Process	GO:0034644	cellular response to UV	Eif2s1	IDA		Mouse	MGI:MGI:5700311|PMID:12176355
Biological Process	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity	Eif2s1	IDA		Rat	PMID:9582312|RGD:1581075
Biological Process	GO:0032057	negative regulation of translational initiation in response to stress	Eif2s1	IDA		Mouse	MGI:MGI:5700311|PMID:12176355
Biological Process	GO:0036499	PERK-mediated unfolded protein response	EIF2S1	IDA		Human	PMID:33384352
Biological Process	GO:1901216	positive regulation of neuron death	EIF2S1	IMP		Human	PMID:18508033
Biological Process	GO:1901216	positive regulation of neuron death	Eif2s1	IMP		Rat	PMID:17251432|RGD:10755427
Biological Process	GO:2000676	positive regulation of type B pancreatic cell apoptotic process	Eif2s1	IMP		Rat	PMID:17158450|RGD:10395350
Biological Process	GO:0046777	protein autophosphorylation	Eif2s1	IDA		Mouse	PMID:19139267
Biological Process	GO:0043558	regulation of translational initiation in response to stress	Eif2s1	IDA		Mouse	PMID:15937339
Biological Process	GO:0034976	response to endoplasmic reticulum stress	EIF2S1	IMP		Human	PMID:18508033
Biological Process	GO:0034976	response to endoplasmic reticulum stress	EIF2S1	IDA		Human	PMID:33384352
Biological Process	GO:0034976	response to endoplasmic reticulum stress	Eif2s1	IDA		Mouse	MGI:MGI:3582244|PMID:11106749
Biological Process	GO:1990737	response to manganese-induced endoplasmic reticulum stress	Eif2s1	IEP		Rat	PMID:23934647|RGD:10047151
Biological Process	GO:0034063	stress granule assembly	Eif2s1	IMP		Mouse	MGI:MGI:6148443|PMID:27430620
Biological Process	GO:0006412	translation	Eif2s1	IDA		Mouse	PMID:10882126
Biological Process	GO:0006412	translation	Eif2s1	IDA		Mouse	PMID:16176978
Biological Process	GO:0006412	translation	Eif2s1	IDA		Mouse	PMID:12388085
Biological Process	GO:0006413	translational initiation	EIF2S1	IDA		Human	PMID:16289705

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern