Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EIF3A
  • Mouse genes Eif3a
  • Rat genes Eif3a
  • Zfish genes eif3s10
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eif3a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	EIF3A	IPI	UniProtKB:P08729	Human	PMID:11169732
Molecular Function	GO:0005515	protein binding	EIF3A	IPI	UniProtKB:P55884	Human	PMID:11169732
Molecular Function	GO:0005515	protein binding	EIF3A	IPI	UniProtKB:P55884	Human	PMID:14688252
Molecular Function	GO:0005515	protein binding	EIF3A	IPI	UniProtKB:P60228	Human	PMID:17468741
Molecular Function	GO:0005515	protein binding	EIF3A	IPI	UniProtKB:Q92900-2	Human	PMID:18423202
Molecular Function	GO:0005515	protein binding	EIF3A	IPI	UniProtKB:P55884	Human	PMID:18599441
Molecular Function	GO:0005515	protein binding	EIF3A	IPI	UniProtKB:Q99613	Human	PMID:18599441
Molecular Function	GO:0005515	protein binding	EIF3A	IPI	UniProtKB:P55884	Human	PMID:18628297
Molecular Function	GO:0005515	protein binding	EIF3A	IPI	UniProtKB:P55884	Human	PMID:19245811
Molecular Function	GO:0005515	protein binding	EIF3A	IPI	UniProtKB:Q9DCH4	Human	PMID:21124883
Molecular Function	GO:0005515	protein binding	EIF3A	IPI	UniProtKB:Q9Q2G4	Human	PMID:22190034
Molecular Function	GO:0005515	protein binding	EIF3A	IPI	UniProtKB:P41567	Human	PMID:23623729
Molecular Function	GO:0005515	protein binding	EIF3A	IPI	UniProtKB:P47813	Human	PMID:23623729
Molecular Function	GO:0005515	protein binding	EIF3A	IPI	UniProtKB:Q99613	Human	PMID:23623729
Molecular Function	GO:0005515	protein binding	EIF3A	IPI	UniProtKB:Q04864	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	Eif3a	IPI	UniProtKB:Q8CDG1	Mouse	MGI:MGI:3842880|PMID:19114715
Molecular Function	GO:0005515	protein binding	Eif3a	IPI	UniProtKB:Q9R0N3	Rat	PMID:24882364|RGD:8693368
Molecular Function	GO:0030971	receptor tyrosine kinase binding	Eif3a	IPI	RGD:620144	Rat	PMID:10691301|RGD:10003117
Molecular Function	GO:0003723	RNA binding	EIF3A	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	EIF3A	HDA		Human	PMID:22681889
Molecular Function	GO:0003723	RNA binding	EIF3A	IDA		Human	PMID:25849773
Molecular Function	GO:0003723	RNA binding	EIF3A	IDA		Human	PMID:27462815
Molecular Function	GO:0003743	translation initiation factor activity	EIF3A	IDA		Human	PMID:17581632
Molecular Function	GO:0003743	translation initiation factor activity	EIF3A	IDA		Human	PMID:25849773
Molecular Function	GO:0003743	translation initiation factor activity	Eif3a	IDA		Mouse	MGI:MGI:3843422|PMID:17581632
Cellular Component	GO:0005829	cytosol	EIF3A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3A	IPI		Human	PMID:17322308
Cellular Component	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3A	IDA		Human	PMID:17322308
Cellular Component	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3A	IDA		Human	PMID:17581632
Cellular Component	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3A	IDA		Human	PMID:18599441
Cellular Component	GO:0005852	eukaryotic translation initiation factor 3 complex	EIF3A	IDA		Human	PMID:25849773
Cellular Component	GO:0005852	eukaryotic translation initiation factor 3 complex	Eif3a	IDA		Mouse	MGI:MGI:3843422|PMID:17581632
Cellular Component	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	Eif3a	IDA		Mouse	PMID:24003236
Cellular Component	GO:0016020	membrane	EIF3A	HDA		Human	PMID:19946888
Cellular Component	GO:0005874	microtubule	Eif3a	IDA		Rat	PMID:22613460|RGD:10755442
Cellular Component	GO:0005730	nucleolus	EIF3A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	EIF3A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Eif3a	IDA		Rat	PMID:15942958|RGD:1598733
Cellular Component	GO:0014069	postsynaptic density	Eif3a	EXP		Mouse	PMID:25211037
Cellular Component	GO:0014069	postsynaptic density	Eif3a	IDA		Mouse	PMID:25211037
Biological Process	GO:0001732	formation of cytoplasmic translation initiation complex	EIF3A	IDA		Human	PMID:17581632
Biological Process	GO:0001732	formation of cytoplasmic translation initiation complex	Eif3a	IDA		Mouse	MGI:MGI:3843422|PMID:17581632
Biological Process	GO:0075522	IRES-dependent viral translational initiation	EIF3A	IDA		Human	PMID:23766293
Biological Process	GO:0075522	IRES-dependent viral translational initiation	EIF3A	IDA		Human	PMID:24357634
Biological Process	GO:0075522	IRES-dependent viral translational initiation	EIF3A	IDA		Human	PMID:9573242
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Eif3a	IMP		Rat	PMID:22025682|RGD:10755441
Biological Process	GO:0075525	viral translational termination-reinitiation	EIF3A	IDA		Human	PMID:21347434

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern