Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EIF4E
  • Mouse genes Eif4e
  • Rat genes Eif4e
  • Zfish genes eif4ea,eif4eb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eif4e

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140297	DNA-binding transcription factor binding	EIF4E	IDA		Human	PMID:23814182
Molecular Function	GO:0019899	enzyme binding	EIF4E	IDA		Human	PMID:23814182
Molecular Function	GO:0031370	eukaryotic initiation factor 4G binding	EIF4E	IDA		Human	PMID:18337562
Molecular Function	GO:0031370	eukaryotic initiation factor 4G binding	EIF4E	IDA		Human	PMID:23814182
Molecular Function	GO:0031370	eukaryotic initiation factor 4G binding	Eif4e	IPI	RGD:1306144	Rat	PMID:18952566|RGD:2307417
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13541	Human	PMID:10772338
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q9NRA8	Human	PMID:10856257
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:O60516	Human	PMID:15153109
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q04637	Human	PMID:15153109
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13541	Human	PMID:15153109
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13542	Human	PMID:15153109
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q04743	Human	PMID:15247416
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q04637	Human	PMID:15361857
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q9NRA8	Human	PMID:16157702
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13541	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:O60516	Human	PMID:16271312
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13541	Human	PMID:16271312
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13542	Human	PMID:16271312
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q9NRA8	Human	PMID:16467844
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13541	Human	PMID:16504179
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q9HC16	Human	PMID:16699599
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q8TEQ6	Human	PMID:16739988
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q04637	Human	PMID:18955708
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13541	Human	PMID:18955708
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q9NRA8	Human	PMID:19060904
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:P42704	Human	PMID:19262567
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13541	Human	PMID:19834456
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:O43432-1	Human	PMID:20212144
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:O73557	Human	PMID:20212144
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q04637	Human	PMID:20212144
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:P63165	Human	PMID:20224576
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13541	Human	PMID:20224576
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q6PKG0	Human	PMID:20430826
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:A6NIX2	Human	PMID:20616046
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q96IF1	Human	PMID:20616046
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q9UGP4	Human	PMID:20616046
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13541	Human	PMID:20880835
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:P67775	Human	PMID:20927323
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:O43432-1	Human	PMID:21191102
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q04637	Human	PMID:21191102
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13541	Human	PMID:21191102
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13541	Human	PMID:22678294
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:P11940	Human	PMID:23665581
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q04637	Human	PMID:23665581
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:P17844	Human	PMID:23788676
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q9NRA8	Human	PMID:23991149
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13542	Human	PMID:24207126
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13541	Human	PMID:24211447
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q9NRA8	Human	PMID:24335285
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:O60516	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:P14373	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:P48775	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13541	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13542	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q63ZY3	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:O43432	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q04637	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13541	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13542	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q9NRA8	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:O60516	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:P14373	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:P48775	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13541	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13542	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q5T124	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q63ZY3	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q9NRA8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:O70552	Human	PMID:27065194
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q60809	Human	PMID:27065194
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q9NRA8	Human	PMID:28487484
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:O43432	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13541	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13542	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q9NRA8	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:O00571	Human	PMID:28733330
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q9BX46	Human	PMID:29358667
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:P14373	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13542	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:O60516	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13541	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13542	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q63ZY3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:O43432	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13541	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q9NRA8	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	EIF4E	IPI	UniProtKB:Q13541	Human	PMID:7651417
Molecular Function	GO:0005515	protein binding	Eif4e	IPI	UniProtKB:O08785	Mouse	MGI:MGI:5447260|PMID:22900038
Molecular Function	GO:0005515	protein binding	Eif4e	IPI	UniProtKB:P29590-4	Mouse	MGI:MGI:3700413|PMID:11500381
Molecular Function	GO:0005515	protein binding	Eif4e	IPI	UniProtKB:Q6NZJ6	Mouse	MGI:MGI:3628832|PMID:16541103
Molecular Function	GO:0005515	protein binding	Eif4e	IPI	UniProtKB:Q60876	Mouse	MGI:MGI:5914849|PMID:19209957
Molecular Function	GO:0005515	protein binding	Eif4e	IPI	UniProtKB:Q6NZJ6	Mouse	MGI:MGI:5473729|PMID:23263185
Molecular Function	GO:0005515	protein binding	Eif4e	IPI	UniProtKB:Q60876	Mouse	MGI:MGI:6093322|PMID:18955708
Molecular Function	GO:0005515	protein binding	Eif4e	IPI	UniProtKB:Q7L576|UniProtKB:Q7TMB8	Mouse	MGI:MGI:4418608|PMID:18805096
Molecular Function	GO:0005515	protein binding	Eif4e	IPI	UniProtKB:Q7TMB8	Mouse	MGI:MGI:4418608|PMID:18805096
Molecular Function	GO:0005515	protein binding	Eif4e	IPI	PR:Q6NZJ6	Mouse	PMID:17556672
Molecular Function	GO:0005515	protein binding	Eif4e	IPI	PR:Q9EST3	Mouse	PMID:16343815
Molecular Function	GO:0005515	protein binding	Eif4e	IPI	PR:Q9EST3	Mouse	PMID:25456498
Molecular Function	GO:0005515	protein binding	Eif4e	IPI	RGD:620259	Rat	PMID:18952566|RGD:2307417
Molecular Function	GO:0005515	protein binding	eif4ea	IPI	UniProtKB:Q04637	Zfish	PMID:14701818|ZFIN:ZDB-PUB-040109-18
Molecular Function	GO:0005515	protein binding	eif4ea	IPI	UniProtKB:Q98TT6	Zfish	PMID:14701818|ZFIN:ZDB-PUB-040109-18
Molecular Function	GO:0000340	RNA 7-methylguanosine cap binding	EIF4E	IDA		Human	PMID:19750007
Molecular Function	GO:0000340	RNA 7-methylguanosine cap binding	eif4ea	IDA		Zfish	PMID:14701818
Molecular Function	GO:0003723	RNA binding	EIF4E	HDA		Human	PMID:22681889
Molecular Function	GO:0003743	translation initiation factor activity	EIF4E	IDA		Human	PMID:22578813
Molecular Function	GO:0003743	translation initiation factor activity	Eif4e	IDA		Mouse	MGI:MGI:3690190|PMID:16289705
Molecular Function	GO:0003743	translation initiation factor activity	eif4ea	IMP		Zfish	PMID:14701818|ZFIN:ZDB-PUB-040109-18
Molecular Function	GO:0003743	translation initiation factor activity	eif4ea	IDA		Zfish	PMID:14701818
Molecular Function	GO:0045182	translation regulator activity	Eif4e	IDA		Mouse	PMID:23263185
Molecular Function	GO:0045182	translation regulator activity	Eif4e	IEP		Mouse	PMID:23263185
Molecular Function	GO:0045182	translation regulator activity	Eif4e	IMP		Mouse	PMID:23263185
Cellular Component	GO:0033391	chromatoid body	Eif4e	IDA		Mouse	PMID:22792342
Cellular Component	GO:0005737	cytoplasm	EIF4E	IDA		Human	PMID:19393246
Cellular Component	GO:0005737	cytoplasm	EIF4E	IDA		Human	PMID:23814182
Cellular Component	GO:0005737	cytoplasm	Eif4e	IDA		Mouse	PMID:12388085
Cellular Component	GO:0005737	cytoplasm	Eif4e	IDA		Mouse	PMID:25456498
Cellular Component	GO:0005737	cytoplasm	eif4ea	IDA		Zfish	PMID:14701818|ZFIN:ZDB-PUB-040109-18
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	EIF4E	IDA		Human	GO_REF:0000052
Cellular Component	GO:0010494	cytoplasmic stress granule	EIF4E	IDA		Human	PMID:21883093
Cellular Component	GO:0005829	cytosol	EIF4E	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	EIF4E	IDA		Human	PMID:19750007
Cellular Component	GO:0016281	eukaryotic translation initiation factor 4F complex	EIF4E	IDA		Human	PMID:22578813
Cellular Component	GO:0016281	eukaryotic translation initiation factor 4F complex	Eif4e	IDA		Rat	PMID:18952566|RGD:2307417
Cellular Component	GO:0070062	extracellular exosome	EIF4E	HDA		Human	PMID:20458337
Cellular Component	GO:0098978	glutamatergic synapse	Eif4e	IDA		Mouse	PMID:11980711
Cellular Component	GO:0098978	glutamatergic synapse	Eif4e	IEP		Mouse	PMID:11980711
Cellular Component	GO:0098978	glutamatergic synapse	Eif4e	IMP		Mouse	PMID:23263185
Cellular Component	GO:0098978	glutamatergic synapse	Eif4e	IDA		Mouse	PMID:23263185
Cellular Component	GO:0098978	glutamatergic synapse	Eif4e	IEP		Mouse	PMID:23263185
Cellular Component	GO:0098978	glutamatergic synapse	Eif4e	IDA		Rat	PMID:11756682|RGD:13702327
Cellular Component	GO:0098978	glutamatergic synapse	Eif4e	IDA		Rat	PMID:12711090|RGD:10401640
Cellular Component	GO:0005845	mRNA cap binding complex	EIF4E	IDA		Human	PMID:16271312
Cellular Component	GO:0005845	mRNA cap binding complex	Eif4e	IDA		Mouse	MGI:MGI:4418608|PMID:18805096
Cellular Component	GO:0005634	nucleus	eif4ea	IDA		Zfish	PMID:14701818|ZFIN:ZDB-PUB-040109-18
Cellular Component	GO:0000932	P-body	EIF4E	IDA		Human	PMID:16157702
Cellular Component	GO:0000932	P-body	EIF4E	IDA		Human	PMID:20616046
Cellular Component	GO:0000932	P-body	EIF4E	IDA		Human	PMID:24335285
Cellular Component	GO:0048471	perinuclear region of cytoplasm	EIF4E	IDA		Human	PMID:23814182
Cellular Component	GO:0098794	postsynapse	Eif4e	IDA		Mouse	PMID:11980711
Cellular Component	GO:0098794	postsynapse	Eif4e	IEP		Mouse	PMID:11980711
Cellular Component	GO:0098794	postsynapse	Eif4e	IDA		Rat	PMID:12711090|RGD:10401640
Cellular Component	GO:0099524	postsynaptic cytosol	Eif4e	IDA		Rat	PMID:11756682|RGD:13702327
Cellular Component	GO:0032991	protein-containing complex	Eif4e	IDA		Rat	PMID:18952566|RGD:2307417
Cellular Component	GO:0016442	RISC complex	EIF4E	IDA		Human	PMID:20616046
Biological Process	GO:0001662	behavioral fear response	Eif4e	IGI	MGI:MGI:2384784	Mouse	PMID:24990923
Biological Process	GO:0001662	behavioral fear response	Eif4e	IGI	MGI:MGI:1270849	Mouse	PMID:24990923
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Eif4e	IDA		Mouse	PMID:17556672
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	EIF4E	IMP		Human	PMID:14673156
Biological Process	GO:0030324	lung development	Eif4e	IEP		Rat	PMID:18952566|RGD:2307417
Biological Process	GO:0045665	negative regulation of neuron differentiation	Eif4e	IMP		Mouse	PMID:25456498
Biological Process	GO:0017148	negative regulation of translation	Eif4e	IMP		Mouse	PMID:25456498
Biological Process	GO:0030182	neuron differentiation	Eif4e	IMP		Mouse	PMID:25456498
Biological Process	GO:0045931	positive regulation of mitotic cell cycle	EIF4E	IMP		Human	PMID:14673156
Biological Process	GO:0006417	regulation of translation	EIF4E	IDA		Human	PMID:22578813
Biological Process	GO:0099578	regulation of translation at postsynapse, modulating synaptic transmission	Eif4e	IDA		Mouse	PMID:23263185
Biological Process	GO:0099578	regulation of translation at postsynapse, modulating synaptic transmission	Eif4e	IEP		Mouse	PMID:23263185
Biological Process	GO:0099578	regulation of translation at postsynapse, modulating synaptic transmission	Eif4e	IMP		Mouse	PMID:23263185
Biological Process	GO:0019827	stem cell population maintenance	Eif4e	IGI	MGI:MGI:1921453	Mouse	PMID:25456498
Biological Process	GO:0019827	stem cell population maintenance	Eif4e	IMP		Mouse	PMID:25456498
Biological Process	GO:0006412	translation	Eif4e	IMP		Mouse	PMID:25456498
Biological Process	GO:0006413	translational initiation	eif4ea	IMP		Zfish	PMID:14701818|ZFIN:ZDB-PUB-040109-18
Biological Process	GO:0006413	translational initiation	eif4ea	IDA		Zfish	PMID:14701818

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern