Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EIF4G1
  • Mouse genes Eif4g1
  • Rat genes Eif4g1
  • Zfish genes eif4g1a,eif4g1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eif4g1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	EIF4G1	IDA		Human	PMID:25255371
Molecular Function	GO:0008190	eukaryotic initiation factor 4E binding	EIF4G1	IDA		Human	PMID:23814182
Molecular Function	GO:0008190	eukaryotic initiation factor 4E binding	Eif4g1	IPI	RGD:69647	Rat	PMID:18952566|RGD:2307417
Molecular Function	GO:0042802	identical protein binding	EIF4G1	IPI	UniProtKB:Q04637	Human	PMID:16698552
Molecular Function	GO:0003729	mRNA binding	EIF4G1	IDA		Human	PMID:24092755
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P38919	Human	PMID:10523622
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P20965	Human	PMID:10970864
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P20965	Human	PMID:10996799
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:Q53EL6	Human	PMID:12054647
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P11940	Human	PMID:12086624
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:Q9DFS6	Human	PMID:14701818
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P06730	Human	PMID:15153109
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P06730	Human	PMID:15361857
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:Q9J0X9	Human	PMID:15567442
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:Q98SP8	Human	PMID:15713657
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:Q14011	Human	PMID:16513844
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:Q14103-4	Human	PMID:16556936
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P11940	Human	PMID:16772376
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:O75822	Human	PMID:16932749
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P60842	Human	PMID:16932749
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:Q9BWF3	Human	PMID:17284590
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:Q9BWF3-1	Human	PMID:17284590
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P60228	Human	PMID:17468741
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:Q15038	Human	PMID:17984221
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P60842	Human	PMID:18606994
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P06730	Human	PMID:18955708
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P60842	Human	PMID:19203580
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P11940	Human	PMID:19716330
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P06730	Human	PMID:20212144
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P06730	Human	PMID:21191102
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:O00571	Human	PMID:22872150
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P60842	Human	PMID:23023399
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P11940	Human	PMID:23041282
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:Q9UKV8	Human	PMID:23409027
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P60842	Human	PMID:23478064
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P06730	Human	PMID:23665581
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P17844	Human	PMID:23788676
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:O15371,UniProtKB:P60228,UniProtKB:Q99613	Human	PMID:24092755
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:Q14103	Human	PMID:24423872
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P06730	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	EIF4G1	IPI	UniProtKB:P41567	Human	PMID:29987188
Molecular Function	GO:0005515	protein binding	Eif4g1	IPI	UniProtKB:P60843|UniProtKB:P63073|UniProtKB:Q8JZQ9|UniProtKB:Q9QZD9	Mouse	MGI:MGI:3628832|PMID:16541103
Molecular Function	GO:0005515	protein binding	Eif4g1	IPI	UniProtKB:P60843	Mouse	MGI:MGI:3836198|PMID:19153607
Molecular Function	GO:0005515	protein binding	Eif4g1	IPI	UniProtKB:P63073	Mouse	MGI:MGI:5473729|PMID:23263185
Molecular Function	GO:0005515	protein binding	Eif4g1	IPI	PR:P63073	Mouse	PMID:17556672
Molecular Function	GO:0003723	RNA binding	EIF4G1	HDA		Human	PMID:22658674
Molecular Function	GO:0008135	translation factor activity, RNA binding	EIF4G1	IMP		Human	PMID:18426977
Molecular Function	GO:0003743	translation initiation factor activity	EIF4G1	IDA		Human	PMID:29987188
Cellular Component	GO:0005737	cytoplasm	EIF4G1	IDA		Human	PMID:17984221
Cellular Component	GO:0005737	cytoplasm	EIF4G1	IMP		Human	PMID:18426977
Cellular Component	GO:0005737	cytoplasm	EIF4G1	IDA		Human	PMID:23814182
Cellular Component	GO:0005737	cytoplasm	Eif4g1	IDA		Mouse	PMID:12388085
Cellular Component	GO:0010494	cytoplasmic stress granule	EIF4G1	IDA		Human	PMID:17984221
Cellular Component	GO:0005829	cytosol	EIF4G1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016281	eukaryotic translation initiation factor 4F complex	EIF4G1	IDA		Human	PMID:25255371
Cellular Component	GO:0016281	eukaryotic translation initiation factor 4F complex	Eif4g1	IDA		Rat	PMID:18952566|RGD:2307417
Cellular Component	GO:0016020	membrane	EIF4G1	HDA		Human	PMID:19946888
Cellular Component	GO:0005634	nucleus	EIF4G1	IDA		Human	PMID:17984221
Cellular Component	GO:0005634	nucleus	EIF4G1	IMP		Human	PMID:18426977
Cellular Component	GO:0005844	polysome	EIF4G1	IMP		Human	PMID:18426977
Cellular Component	GO:0098794	postsynapse	Eif4g1	IDA		Rat	PMID:12451124|RGD:628491
Biological Process	GO:0001662	behavioral fear response	Eif4g1	IGI	MGI:MGI:1270849	Mouse	PMID:24990923
Biological Process	GO:0001662	behavioral fear response	Eif4g1	IGI	MGI:MGI:95305	Mouse	PMID:24990923
Biological Process	GO:0031669	cellular response to nutrient levels	EIF4G1	IMP		Human	PMID:18426977
Biological Process	GO:0097009	energy homeostasis	EIF4G1	IMP		Human	PMID:18426977
Biological Process	GO:0030324	lung development	Eif4g1	IEP		Rat	PMID:15388509|RGD:2307418
Biological Process	GO:0009059	macromolecule biosynthetic process	EIF4G1	IGI	UniProtKB:P78344	Human	PMID:18426977
Biological Process	GO:0035278	miRNA-mediated gene silencing by inhibition of translation	EIF4G1	IDA		Human	PMID:23409027
Biological Process	GO:0010507	negative regulation of autophagy	EIF4G1	IMP		Human	PMID:18426977
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	EIF4G1	IMP		Human	PMID:18426977
Biological Process	GO:0030182	neuron differentiation	Eif4g1	IMP		Mouse	PMID:25456498
Biological Process	GO:0010942	positive regulation of cell death	EIF4G1	IGI	UniProtKB:P32319	Human	PMID:25533483
Biological Process	GO:0010942	positive regulation of cell death	EIF4G1	IGI	UniProtKB:P34110,UniProtKB:Q96QK1	Human	PMID:25533483
Biological Process	GO:0030307	positive regulation of cell growth	EIF4G1	IMP		Human	PMID:18426977
Biological Process	GO:1905537	positive regulation of eukaryotic translation initiation factor 4F complex assembly	EIF4G1	IMP		Human	PMID:18426977
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	EIF4G1	IMP		Human	PMID:18426977
Biological Process	GO:1905612	positive regulation of mRNA cap binding	EIF4G1	IDA		Human	PMID:23409027
Biological Process	GO:0045666	positive regulation of neuron differentiation	Eif4g1	IMP		Mouse	PMID:25456498
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	EIF4G1	IMP		Human	PMID:18426977
Biological Process	GO:0051247	positive regulation of protein metabolic process	EIF4G1	IMP		Human	PMID:18426977
Biological Process	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress	EIF4G1	IMP		Human	PMID:29062139
Biological Process	GO:1905696	regulation of polysome binding	EIF4G1	IMP		Human	PMID:18426977
Biological Process	GO:1905606	regulation of presynapse assembly	EIF4G1	IGI	UniProtKB:Q21053	Human	PMID:25533483
Biological Process	GO:0006446	regulation of translational initiation	EIF4G1	IMP		Human	PMID:19648179
Biological Process	GO:0045471	response to ethanol	Eif4g1	IEP		Rat	PMID:15388509|RGD:2307418
Biological Process	GO:0006412	translation	EIF4G1	IMP		Human	PMID:18426977
Biological Process	GO:0006412	translation	EIF4G1	IPI	UniProtKB:O15371,UniProtKB:P60228,UniProtKB:Q99613	Human	PMID:24092755
Biological Process	GO:0006413	translational initiation	EIF4G1	IDA		Human	PMID:29987188

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern