Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EIF4G2
  • Mouse genes Eif4g2
  • Rat genes Eif4g2
  • Zfish genes eif4g2a,eif4g2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eif4g2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	EIF4G2	HDA		Human	PMID:25468996
Molecular Function	GO:0005515	protein binding	EIF4G2	IPI	UniProtKB:P60842	Human	PMID:16166382
Molecular Function	GO:0005515	protein binding	EIF4G2	IPI	UniProtKB:P20042	Human	PMID:16932749
Molecular Function	GO:0005515	protein binding	EIF4G2	IPI	UniProtKB:P60842	Human	PMID:16932749
Molecular Function	GO:0005515	protein binding	EIF4G2	IPI	UniProtKB:Q15038	Human	PMID:17984221
Molecular Function	GO:0005515	protein binding	EIF4G2	IPI	UniProtKB:P29991:PRO_0000308465	Human	PMID:21911577
Molecular Function	GO:0005515	protein binding	EIF4G2	IPI	UniProtKB:P04792	Human	PMID:25277244
Molecular Function	GO:0005515	protein binding	Eif4g2	IPI	UniProtKB:Q61823	Mouse	MGI:MGI:3687918|PMID:12482958
Molecular Function	GO:0005515	protein binding	Eif4g2	IPI	UniProtKB:P26450	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Eif4g2	IPI	PR:P10126	Mouse	PMID:21689717
Molecular Function	GO:0003723	RNA binding	EIF4G2	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	EIF4G2	HDA		Human	PMID:22681889
Molecular Function	GO:0008135	translation factor activity, RNA binding	EIF4G2	IDA		Human	PMID:16289705
Molecular Function	GO:0003743	translation initiation factor activity	EIF4G2	IDA		Human	PMID:11943866
Molecular Function	GO:0003743	translation initiation factor activity	Eif4g2	IDA		Mouse	MGI:MGI:85696|PMID:9030685
Cellular Component	GO:0005912	adherens junction	EIF4G2	HDA		Human	PMID:25468996
Cellular Component	GO:0030424	axon	Eif4g2	IDA		Rat	PMID:23616526|RGD:11041877
Cellular Component	GO:0005737	cytoplasm	Eif4g2	IDA		Mouse	PMID:12388085
Cellular Component	GO:0005829	cytosol	EIF4G2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016281	eukaryotic translation initiation factor 4F complex	EIF4G2	IDA		Human	PMID:11943866
Cellular Component	GO:0016020	membrane	EIF4G2	HDA		Human	PMID:19946888
Cellular Component	GO:0014069	postsynaptic density	Eif4g2	EXP		Mouse	PMID:25211037
Cellular Component	GO:0014069	postsynaptic density	Eif4g2	IDA		Mouse	PMID:25211037
Biological Process	GO:0007507	heart development	Eif4g2	IEP		Rat	PMID:10471355|RGD:70273
Biological Process	GO:0009059	macromolecule biosynthetic process	EIF4G2	IGI	UniProtKB:Q04637	Human	PMID:18426977
Biological Process	GO:0007498	mesoderm development	eif4g2a	IGI	ZFIN:ZDB-MRPHLNO-070929-3	Zfish	PMID:17237356
Biological Process	GO:0007498	mesoderm development	eif4g2a	IGI	ZFIN:ZDB-MRPHLNO-070929-1,ZFIN:ZDB-MRPHLNO-070929-2	Zfish	PMID:17237356
Biological Process	GO:0007498	mesoderm development	eif4g2b	IGI	ZFIN:ZDB-MRPHLNO-070929-3	Zfish	PMID:17237356
Biological Process	GO:0007498	mesoderm development	eif4g2b	IGI	ZFIN:ZDB-MRPHLNO-070929-1,ZFIN:ZDB-MRPHLNO-070929-2	Zfish	PMID:17237356
Biological Process	GO:0010507	negative regulation of autophagy	EIF4G2	IMP		Human	PMID:18426977
Biological Process	GO:0045773	positive regulation of axon extension	Eif4g2	IMP		Rat	PMID:23616526|RGD:11041877
Biological Process	GO:0030307	positive regulation of cell growth	EIF4G2	IMP		Human	PMID:18426977
Biological Process	GO:0060999	positive regulation of dendritic spine development	Eif4g2	IMP		Rat	PMID:22514323|RGD:10755512
Biological Process	GO:0045727	positive regulation of translation	Eif4g2	IMP		Rat	PMID:22514323|RGD:10755512
Biological Process	GO:0006446	regulation of translational initiation	EIF4G2	IDA		Human	PMID:11943866
Biological Process	GO:0006446	regulation of translational initiation	Eif4g2	IDA		Mouse	MGI:MGI:85696|PMID:9030685

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern