Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EIF5
  • Mouse genes Eif5
  • Rat genes Eif5
  • Zfish genes eif5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eif5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	EIF5	HDA		Human	PMID:25468996
Molecular Function	GO:0071074	eukaryotic initiation factor eIF2 binding	Eif5	IDA		Rat	PMID:10805737|RGD:10755758
Molecular Function	GO:0005515	protein binding	EIF5	IPI	UniProtKB:P20042	Human	PMID:21745818
Molecular Function	GO:0005515	protein binding	EIF5	IPI	UniProtKB:Q06787	Human	PMID:24658146
Molecular Function	GO:0005515	protein binding	EIF5	IPI	UniProtKB:Q9UNI6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EIF5	IPI	UniProtKB:Q9UNI6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF5	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0003723	RNA binding	EIF5	HDA		Human	PMID:22681889
Molecular Function	GO:0003743	translation initiation factor activity	Eif5	IDA		Rat	PMID:8464924|RGD:728212
Cellular Component	GO:0005737	cytoplasm	EIF5	IDA		Human	PMID:12426392
Cellular Component	GO:0005829	cytosol	EIF5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	EIF5	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045202	synapse	Eif5	IDA		Mouse	PMID:25211037
Cellular Component	GO:0045202	synapse	Eif5	EXP		Mouse	PMID:25211037
Biological Process	GO:0090630	activation of GTPase activity	Eif5	IDA		Rat	PMID:10805737|RGD:10755758
Biological Process	GO:0001731	formation of translation preinitiation complex	Eif5	IMP		Rat	PMID:10805737|RGD:10755758
Biological Process	GO:0001731	formation of translation preinitiation complex	Eif5	IDA		Rat	PMID:8464924|RGD:728212
Biological Process	GO:0006446	regulation of translational initiation	EIF5	IDA		Human	PMID:22156057

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern