Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EIF5A,EIF5AL1
  • Mouse genes Eif5a
  • Rat genes Eif5a
  • Zfish genes eif5a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eif5a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	EIF5A	IPI	UniProtKB:Q9PW90	Human	PMID:10381392
Molecular Function	GO:0005515	protein binding	EIF5A	IPI	UniProtKB:Q9C0E2	Human	PMID:10944119
Molecular Function	GO:0005515	protein binding	EIF5A	IPI	UniProtKB:P49366	Human	PMID:14622290
Molecular Function	GO:0005515	protein binding	EIF5A	IPI	UniProtKB:O00560	Human	PMID:15371445
Molecular Function	GO:0005515	protein binding	EIF5A	IPI	UniProtKB:Q9BU89	Human	PMID:17213197
Molecular Function	GO:0005515	protein binding	EIF5A	IPI	UniProtKB:O43186	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EIF5A	IPI	UniProtKB:P49366	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EIF5A	IPI	UniProtKB:P50222	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EIF5A	IPI	UniProtKB:Q04864	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EIF5A	IPI	UniProtKB:A8MW99	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF5A	IPI	UniProtKB:O00560	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF5A	IPI	UniProtKB:O15499	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF5A	IPI	UniProtKB:P49366	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF5A	IPI	UniProtKB:P52954	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF5A	IPI	UniProtKB:Q04864-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF5A	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF5A	IPI	UniProtKB:Q9NRD5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EIF5A	IPI	UniProtKB:P21980	Human	PMID:9442029
Molecular Function	GO:0005515	protein binding	EIF5A	IPI	UniProtKB:P46777	Human	PMID:9465063
Molecular Function	GO:0003723	RNA binding	EIF5A	IDA		Human	PMID:15303967
Molecular Function	GO:0003723	RNA binding	EIF5A	HDA		Human	PMID:22681889
Molecular Function	GO:0017070	U6 snRNA binding	EIF5A	IDA		Human	PMID:9285100
Cellular Component	GO:0005642	annulate lamellae	EIF5A	IDA		Human	PMID:12210765
Cellular Component	GO:0005737	cytoplasm	EIF5A	IDA		Human	PMID:12210765
Cellular Component	GO:0005737	cytoplasm	EIF5A	IDA		Human	PMID:17187778
Cellular Component	GO:0005737	cytoplasm	Eif5a	IDA		Mouse	PMID:17707773
Cellular Component	GO:0005737	cytoplasm	Eif5a	IDA		Mouse	PMID:12894223
Cellular Component	GO:0030425	dendrite	Eif5a	IDA		Rat	PMID:18606156|RGD:2308860
Cellular Component	GO:0016020	membrane	EIF5A	HDA		Human	PMID:19946888
Cellular Component	GO:0043025	neuronal cell body	Eif5a	IDA		Rat	PMID:18606156|RGD:2308860
Cellular Component	GO:0005643	nuclear pore	EIF5A	IDA		Human	PMID:10381392
Cellular Component	GO:0005634	nucleus	EIF5A	IDA		Human	PMID:12210765
Cellular Component	GO:0005634	nucleus	EIF5A	IDA		Human	PMID:17187778
Cellular Component	GO:0005634	nucleus	Eif5a	IDA		Mouse	PMID:12894223
Cellular Component	GO:0005634	nucleus	Eif5a	IDA		Mouse	PMID:17707773
Cellular Component	GO:0045202	synapse	Eif5a	EXP		Mouse	PMID:25211037
Cellular Component	GO:0045202	synapse	Eif5a	IDA		Mouse	PMID:25211037
Cellular Component	GO:0045202	synapse	Eif5a	EXP		Rat	PMID:14532281|RGD:13702402
Cellular Component	GO:0045202	synapse	Eif5a	IDA		Rat	PMID:14532281|RGD:13702402
Biological Process	GO:0007568	aging	Eif5a	IEP		Rat	PMID:18606156|RGD:2308860
Biological Process	GO:0097067	cellular response to thyroid hormone stimulus	Eif5a	IEP		Rat	PMID:22667453|RGD:10395361
Biological Process	GO:0098586	cellular response to virus	EIF5A	IMP		Human	PMID:8596953
Biological Process	GO:0098586	cellular response to virus	EIF5A	IMP		Human	PMID:9465063
Biological Process	GO:0043066	negative regulation of apoptotic process	Eif5a	IMP		Rat	PMID:9396730|RGD:2308862
Biological Process	GO:0043065	positive regulation of apoptotic process	Eif5a	IDA		Mouse	PMID:12894223
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	Eif5a	IMP		Rat	PMID:20930373|RGD:10395362
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Eif5a	IMP		Rat	PMID:20930373|RGD:10395362
Biological Process	GO:1902255	positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	EIF5A	IDA		Human	PMID:15371445
Biological Process	GO:0051149	positive regulation of muscle cell differentiation	Eif5a	IMP		Rat	PMID:19006180|RGD:2308859
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	Eif5a	IMP		Rat	PMID:20930373|RGD:10395362
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	EIF5A	IMP		Human	PMID:15371445
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	EIF5A	IDA		Human	PMID:17187778

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern