Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ELANE
  • Mouse genes Elane
  • Rat genes Elane
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Elane

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019955	cytokine binding	ELANE	IPI	UniProtKB:P09919	Human	PMID:12393522
Molecular Function	GO:0004175	endopeptidase activity	ELANE	IDA		Human	PMID:12887060
Molecular Function	GO:0004175	endopeptidase activity	ELANE	IDA		Human	PMID:6980881
Molecular Function	GO:0008201	heparin binding	ELANE	IDA		Human	PMID:11907569
Molecular Function	GO:0008233	peptidase activity	ELANE	IDA		Human	PMID:11907569
Molecular Function	GO:0008233	peptidase activity	ELANE	IDA		Human	PMID:20421939
Molecular Function	GO:0002020	protease binding	ELANE	IPI	UniProtKB:P08697	Human	PMID:6980881
Molecular Function	GO:0005515	protein binding	ELANE	IPI	UniProtKB:P05121	Human	PMID:12114510
Molecular Function	GO:0005515	protein binding	ELANE	IPI	UniProtKB:P25942	Human	PMID:12223522
Molecular Function	GO:0005515	protein binding	ELANE	IPI	UniProtKB:Q03405	Human	PMID:14688365
Molecular Function	GO:0005515	protein binding	ELANE	IPI	UniProtKB:Q92802	Human	PMID:19506020
Molecular Function	GO:0005515	protein binding	ELANE	IPI	UniProtKB:Q99684	Human	PMID:19506020
Molecular Function	GO:0005515	protein binding	ELANE	IPI	UniProtKB:Q07563	Human	PMID:21979170
Molecular Function	GO:0005515	protein binding	ELANE	IPI	UniProtKB:P0DTC2	Human	PMID:33748632
Molecular Function	GO:0004252	serine-type endopeptidase activity	ELANE	EXP		Human	PMID:29539421
Molecular Function	GO:0004252	serine-type endopeptidase activity	Elane	IDA		Mouse	PMID:17878334
Molecular Function	GO:0003714	transcription corepressor activity	ELANE	IMP		Human	PMID:19506020
Cellular Component	GO:0009986	cell surface	ELANE	IDA		Human	PMID:12114510
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ELANE	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	ELANE	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Elane	HDA		Mouse	MGI:MGI:6201834|PMID:22159717
Cellular Component	GO:0005737	cytoplasm	ELANE	IDA		Human	PMID:19506020
Cellular Component	GO:0005737	cytoplasm	Elane	IDA		Mouse	PMID:17878334
Cellular Component	GO:0070062	extracellular exosome	ELANE	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ELANE	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	ELANE	IDA		Human	PMID:20421939
Cellular Component	GO:0005615	extracellular space	ELANE	IDA		Human	PMID:25645918
Cellular Component	GO:0030141	secretory granule	ELANE	IDA		Human	PMID:11907569
Cellular Component	GO:0017053	transcription repressor complex	ELANE	IDA		Human	PMID:19506020
Biological Process	GO:0002438	acute inflammatory response to antigenic stimulus	Elane	IDA		Mouse	PMID:17878334
Biological Process	GO:0002812	biosynthetic process of antibacterial peptides active against Gram-negative bacteria	ELANE	IDA		Human	PMID:20421939
Biological Process	GO:0042742	defense response to bacterium	ELANE	IDA		Human	PMID:14705961
Biological Process	GO:0050832	defense response to fungus	Elane	IMP	MGI:MGI:2182177	Mouse	PMID:11907569
Biological Process	GO:0050832	defense response to fungus	Elane	IGI	MGI:MGI:88563	Mouse	PMID:10714686
Biological Process	GO:0050832	defense response to fungus	Elane	IMP	MGI:MGI:2182177	Mouse	PMID:10714686
Biological Process	GO:0050900	leukocyte migration	Elane	IMP	MGI:MGI:2182771	Mouse	PMID:15034066
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	Elane	IMP		Rat	PMID:20860667|RGD:10450565
Biological Process	GO:0032682	negative regulation of chemokine production	ELANE	IDA		Human	PMID:12223522
Biological Process	GO:0032717	negative regulation of interleukin-8 production	ELANE	IDA		Human	PMID:12223522
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ELANE	IMP		Human	PMID:19506020
Biological Process	GO:0070947	neutrophil-mediated killing of fungus	Elane	IMP	MGI:MGI:2182177	Mouse	PMID:11907569
Biological Process	GO:0070945	neutrophil-mediated killing of gram-negative bacterium	ELANE	IDA		Human	PMID:20421939
Biological Process	GO:0006909	phagocytosis	Elane	IMP	MGI:MGI:2182771	Mouse	PMID:15034066
Biological Process	GO:0050778	positive regulation of immune response	Elane	IGI	MGI:MGI:88563	Mouse	PMID:10714686
Biological Process	GO:0050778	positive regulation of immune response	Elane	IMP	MGI:MGI:2182177	Mouse	PMID:10714686
Biological Process	GO:0032757	positive regulation of interleukin-8 production	ELANE	IDA		Human	PMID:14730209
Biological Process	GO:1903238	positive regulation of leukocyte tethering or rolling	Elane	IMP		Rat	PMID:20860667|RGD:10450565
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ELANE	IDA		Human	PMID:15010259
Biological Process	GO:0006508	proteolysis	ELANE	IDA		Human	PMID:11907569
Biological Process	GO:0006508	proteolysis	ELANE	IDA		Human	PMID:20421939
Biological Process	GO:0032496	response to lipopolysaccharide	Elane	IGI	MGI:MGI:88563	Mouse	PMID:10714686
Biological Process	GO:0032496	response to lipopolysaccharide	Elane	IMP	MGI:MGI:2182177	Mouse	PMID:10714686
Biological Process	GO:0009411	response to UV	ELANE	IDA		Human	PMID:11928814
Biological Process	GO:0001878	response to yeast	Elane	IMP	MGI:MGI:2182177	Mouse	PMID:11907569

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern