Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ELF4
  • Mouse genes Elf4
  • Rat genes Elf4
  • Zfish genes elf1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Elf4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ELF4	IDA		Human	PMID:14625302
Molecular Function	GO:0005515	protein binding	ELF4	IPI	UniProtKB:Q01196	Human	PMID:10207087
Molecular Function	GO:0005515	protein binding	ELF4	IPI	UniProtKB:Q01196-8	Human	PMID:10207087
Molecular Function	GO:0005515	protein binding	ELF4	IPI	UniProtKB:Q01196	Human	PMID:14970218
Molecular Function	GO:0005515	protein binding	ELF4	IPI	UniProtKB:Q01196-1	Human	PMID:14970218
Molecular Function	GO:0005515	protein binding	ELF4	IPI	UniProtKB:P29590	Human	PMID:14976184
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ELF4	IDA		Human	PMID:14625302
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ELF4	IDA		Human	PMID:28473536
Cellular Component	GO:0016604	nuclear body	ELF4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	ELF4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016605	PML body	ELF4	IDA		Human	PMID:14970218
Biological Process	GO:0001787	natural killer cell proliferation	Elf4	IDA		Mouse	MGI:MGI:2388503|PMID:12387738
Biological Process	GO:0050728	negative regulation of inflammatory response	ELF4	IMP		Human	PMID:34326534
Biological Process	GO:0050728	negative regulation of inflammatory response	Elf4	IMP		Mouse	MGI:MGI:6740250|PMID:34326534
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	ELF4	IMP		Human	PMID:34326534
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	Elf4	IMP		Mouse	MGI:MGI:6740250|PMID:34326534
Biological Process	GO:0032715	negative regulation of interleukin-6 production	ELF4	IMP		Human	PMID:34326534
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Elf4	IMP		Mouse	MGI:MGI:6740250|PMID:34326534
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	ELF4	IMP		Human	PMID:35266071
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Elf4	IMP		Mouse	MGI:MGI:7341386|PMID:35266071
Biological Process	GO:0001866	NK T cell proliferation	Elf4	IDA		Mouse	MGI:MGI:2388503|PMID:12387738
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ELF4	IDA		Human	PMID:14625302
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ELF4	IDA		Human	PMID:8895518
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ELF4	IDA		Human	PMID:9524226
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Elf4	IDA		Mouse	MGI:MGI:2388503|PMID:12387738
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ELF4	IDA		Human	PMID:14625302
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ELF4	IDA		Human	PMID:14970218
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ELF4	IDA		Human	PMID:8895518
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ELF4	IDA		Human	PMID:9524226
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Elf4	IDA		Mouse	MGI:MGI:2388503|PMID:12387738

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern