Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ELMO1
  • Mouse genes Elmo1
  • Rat genes Elmo1
  • Zfish genes elmo1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Elmo1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ELMO1	IDA		Human	PMID:12134158
Molecular Function	GO:0005515	protein binding	ELMO1	IPI	UniProtKB:P08631	Human	PMID:12029088
Molecular Function	GO:0005515	protein binding	ELMO1	IPI	UniProtKB:Q14185	Human	PMID:12134158
Molecular Function	GO:0005515	protein binding	ELMO1	IPI	UniProtKB:P84095	Human	PMID:12879077
Molecular Function	GO:0005515	protein binding	ELMO1	IPI	UniProtKB:Q14185	Human	PMID:15247908
Molecular Function	GO:0005515	protein binding	ELMO1	IPI	UniProtKB:Q14185	Human	PMID:15723800
Molecular Function	GO:0005515	protein binding	ELMO1	IPI	UniProtKB:Q14185	Human	PMID:18768751
Molecular Function	GO:0005515	protein binding	ELMO1	IPI	UniProtKB:O60242	Human	PMID:24567399
Molecular Function	GO:0005515	protein binding	ELMO1	IPI	UniProtKB:Q8TD17	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ELMO1	IPI	UniProtKB:Q9BYV2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ELMO1	IPI	UniProtKB:Q14185	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	ELMO1	IPI	UniProtKB:Q8TD17	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	ELMO1	IPI	UniProtKB:Q8TD17	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	Elmo1	IPI	UniProtKB:Q80ZF8	Mouse	MGI:MGI:5644012|PMID:23628982
Molecular Function	GO:0005515	protein binding	Elmo1	IPI	UniProtKB:Q8BUR4	Mouse	MGI:MGI:3688344|PMID:15102471
Molecular Function	GO:0005515	protein binding	Elmo1	IPI	UniProtKB:Q3UHD1	Mouse	MGI:MGI:3764740|PMID:17960134
Molecular Function	GO:0005515	protein binding	Elmo1	IPI	PR:B2RY04	Mouse	PMID:27505886
Molecular Function	GO:0017124	SH3 domain binding	ELMO1	IPI	UniProtKB:P08631	Human	PMID:12029088
Cellular Component	GO:0005737	cytoplasm	ELMO1	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005737	cytoplasm	ELMO1	IDA		Human	PMID:11595183
Cellular Component	GO:0032045	guanyl-nucleotide exchange factor complex	ELMO1	IDA		Human	PMID:12134158
Cellular Component	GO:0032045	guanyl-nucleotide exchange factor complex	Elmo1	IDA		Mouse	MGI:MGI:2151718|PMID:11595183
Cellular Component	GO:0016020	membrane	ELMO1	HDA		Human	PMID:19946888
Cellular Component	GO:0005886	plasma membrane	ELMO1	IDA		Human	PMID:11595183
Biological Process	GO:0030036	actin cytoskeleton organization	ELMO1	IGI	UniProtKB:P46108,UniProtKB:Q14185	Human	PMID:11595183
Biological Process	GO:0030029	actin filament-based process	Elmo1	IDA		Mouse	PMID:11595183
Biological Process	GO:0048870	cell motility	ELMO1	IGI	UniProtKB:Q8STE5	Human	PMID:11595183
Biological Process	GO:0060271	cilium assembly	elmo1	IGI	ZFIN:ZDB-MRPHLNO-060919-3,ZFIN:ZDB-MRPHLNO-110310-2	Zfish	PMID:25516973
Biological Process	GO:0001946	lymphangiogenesis	elmo1	IMP	ZFIN:ZDB-MRPHLNO-110310-2	Zfish	PMID:20466982
Biological Process	GO:0006909	phagocytosis	Elmo1	IDA		Mouse	PMID:11595183
Biological Process	GO:0006911	phagocytosis, engulfment	ELMO1	IGI	UniProtKB:P46108,UniProtKB:Q14185	Human	PMID:11595183
Biological Process	GO:0045766	positive regulation of angiogenesis	elmo1	IMP	ZFIN:ZDB-MRPHLNO-110310-2	Zfish	PMID:20466982
Biological Process	GO:0016601	Rac protein signal transduction	ELMO1	IGI	UniProtKB:P46108,UniProtKB:Q14185	Human	PMID:11595183

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern