Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EMC2
  • Mouse genes Emc2
  • Rat genes Emc2
  • Zfish genes emc2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Emc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0032977	membrane insertase activity	EMC2	IMP		Human	PMID:29809151
Molecular Function	GO:0032977	membrane insertase activity	EMC2	IMP		Human	PMID:30415835
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:O43402	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:Q9Y3B6	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:O43402	Human	PMID:22119785
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:Q8N4V1	Human	PMID:22119785
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:Q9P0I2	Human	PMID:22119785
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:Q9Y3B6	Human	PMID:22119785
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:Q53Y03	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:Q9UKT9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:Q9Y3B6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:O43402	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:Q8N4V1	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:Q9P0I2	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:O43402	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:Q8N4V1	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:Q9Y3B6	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:O43402	Human	PMID:30021884
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:O43402	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:Q7L8J4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:Q96GW1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:Q9UHA2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:Q9Y3B6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:Q9Y5F1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:O43402	Human	PMID:32439656
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:Q8N4V1	Human	PMID:32439656
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:Q9P0I2	Human	PMID:32439656
Molecular Function	GO:0005515	protein binding	EMC2	IPI	UniProtKB:Q9Y3B6	Human	PMID:32439656
Cellular Component	GO:0005737	cytoplasm	EMC2	IDA		Human	PMID:22119785
Cellular Component	GO:0072546	EMC complex	EMC2	IPI		Human	PMID:32439656
Cellular Component	GO:0072546	EMC complex	EMC2	IDA		Human	PMID:22119785
Cellular Component	GO:0005783	endoplasmic reticulum	EMC2	IDA		Human	PMID:10942595
Cellular Component	GO:0005789	endoplasmic reticulum membrane	EMC2	IDA		Human	PMID:22119785
Cellular Component	GO:0042406	extrinsic component of endoplasmic reticulum membrane	EMC2	IDA		Human	PMID:32439656
Cellular Component	GO:0005739	mitochondrion	Emc2	HDA		Mouse	PMID:18614015
Biological Process	GO:0045050	protein insertion into ER membrane by stop-transfer membrane-anchor sequence	EMC2	IDA		Human	PMID:29242231
Biological Process	GO:0045050	protein insertion into ER membrane by stop-transfer membrane-anchor sequence	EMC2	IMP		Human	PMID:29809151
Biological Process	GO:0045050	protein insertion into ER membrane by stop-transfer membrane-anchor sequence	EMC2	IMP		Human	PMID:30415835
Biological Process	GO:0071816	tail-anchored membrane protein insertion into ER membrane	EMC2	IDA		Human	PMID:29242231

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern