Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EMC4
  • Mouse genes Emc4
  • Rat genes Emc4
  • Zfish genes emc4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Emc4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0032977	membrane insertase activity	EMC4	IMP		Human	PMID:29809151
Molecular Function	GO:0032977	membrane insertase activity	EMC4	IMP		Human	PMID:30415835
Molecular Function	GO:0005515	protein binding	EMC4	IPI	UniProtKB:Q9NRM0-1	Human	PMID:31695625
Molecular Function	GO:0005515	protein binding	EMC4	IPI	UniProtKB:Q9NRM0-2	Human	PMID:31695625
Cellular Component	GO:0072546	EMC complex	EMC4	IPI		Human	PMID:32439656
Cellular Component	GO:0072546	EMC complex	EMC4	IDA		Human	PMID:22119785
Cellular Component	GO:0005789	endoplasmic reticulum membrane	EMC4	IDA		Human	PMID:32439656
Cellular Component	GO:0016020	membrane	EMC4	IDA		Human	PMID:22119785
Biological Process	GO:0045050	protein insertion into ER membrane by stop-transfer membrane-anchor sequence	EMC4	IDA		Human	PMID:29242231
Biological Process	GO:0045050	protein insertion into ER membrane by stop-transfer membrane-anchor sequence	EMC4	IMP		Human	PMID:29809151
Biological Process	GO:0045050	protein insertion into ER membrane by stop-transfer membrane-anchor sequence	EMC4	IMP		Human	PMID:30415835
Biological Process	GO:0071816	tail-anchored membrane protein insertion into ER membrane	EMC4	IDA		Human	PMID:29242231

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern