Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EMP2
  • Mouse genes Emp2
  • Rat genes Emp2
  • Zfish genes emp2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Emp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005178	integrin binding	EMP2	IPI	UniProtKB:P05106	Human	PMID:16216233
Molecular Function	GO:0005178	integrin binding	Emp2	IPI	UniProtKB:P09055	Mouse	MGI:MGI:5605959|PMID:12189152
Molecular Function	GO:0019900	kinase binding	EMP2	IPI	UniProtKB:Q05397	Human	PMID:19494199
Molecular Function	GO:0005515	protein binding	EMP2	IPI	UniProtKB:Q99572	Human	PMID:12107182
Molecular Function	GO:0019901	protein kinase binding	EMP2	IPI	UniProtKB:Q05397	Human	PMID:21637765
Cellular Component	GO:0045177	apical part of cell	Emp2	IDA		Mouse	MGI:MGI:3628891|PMID:16487956
Cellular Component	GO:0016324	apical plasma membrane	Emp2	IDA		Mouse	MGI:MGI:5607239|PMID:18400107
Cellular Component	GO:0016324	apical plasma membrane	Emp2	IDA		Mouse	PMID:16216233
Cellular Component	GO:0009986	cell surface	Emp2	IDA		Mouse	MGI:MGI:3628891|PMID:16487956
Cellular Component	GO:0005737	cytoplasm	EMP2	IDA		Human	PMID:21637765
Cellular Component	GO:0005737	cytoplasm	Emp2	IDA		Mouse	MGI:MGI:3610242|PMID:16216233
Cellular Component	GO:0005737	cytoplasm	Emp2	IDA		Mouse	MGI:MGI:5607239|PMID:18400107
Cellular Component	GO:0005737	cytoplasm	Emp2	IDA		Rat	PMID:24814193|RGD:10047388
Cellular Component	GO:0031410	cytoplasmic vesicle	Emp2	IDA		Mouse	MGI:MGI:5605959|PMID:12189152
Cellular Component	GO:0005794	Golgi apparatus	EMP2	IDA		Human	PMID:18400107
Cellular Component	GO:0005794	Golgi apparatus	Emp2	IDA		Mouse	MGI:MGI:3628891|PMID:16487956
Cellular Component	GO:0005794	Golgi apparatus	Emp2	IDA		Mouse	MGI:MGI:3047005|PMID:14978215
Cellular Component	GO:0005794	Golgi apparatus	Emp2	IDA		Mouse	MGI:MGI:5605959|PMID:12189152
Cellular Component	GO:0045121	membrane raft	EMP2	IDA		Human	PMID:21637765
Cellular Component	GO:0045121	membrane raft	Emp2	IDA		Mouse	MGI:MGI:3047005|PMID:14978215
Cellular Component	GO:0045121	membrane raft	Emp2	IDA		Mouse	MGI:MGI:5605955|PMID:12763482
Cellular Component	GO:0005634	nucleus	Emp2	IDA		Rat	PMID:24814193|RGD:10047388
Cellular Component	GO:0005886	plasma membrane	EMP2	IDA		Human	PMID:12107182
Cellular Component	GO:0005886	plasma membrane	EMP2	IDA		Human	PMID:18400107
Cellular Component	GO:0005886	plasma membrane	EMP2	IDA		Human	PMID:21637765
Cellular Component	GO:0005886	plasma membrane	Emp2	IDA		Mouse	MGI:MGI:5605959|PMID:12189152
Biological Process	GO:0007015	actin filament organization	EMP2	IDA		Human	PMID:19494199
Biological Process	GO:0070252	actin-mediated cell contraction	EMP2	IDA		Human	PMID:18469192
Biological Process	GO:0070252	actin-mediated cell contraction	EMP2	IDA		Human	PMID:22728127
Biological Process	GO:0032147	activation of protein kinase activity	EMP2	IDA		Human	PMID:21637765
Biological Process	GO:0032060	bleb assembly	EMP2	IDA		Human	PMID:12107182
Biological Process	GO:0043534	blood vessel endothelial cell migration	EMP2	IDA		Human	PMID:23439602
Biological Process	GO:0007155	cell adhesion	EMP2	IDA		Human	PMID:19494199
Biological Process	GO:0008219	cell death	EMP2	IDA		Human	PMID:12107182
Biological Process	GO:0016477	cell migration	EMP2	IDA		Human	PMID:21637765
Biological Process	GO:0007160	cell-matrix adhesion	EMP2	IDA		Human	PMID:19494199
Biological Process	GO:0045022	early endosome to late endosome transport	Emp2	IDA		Mouse	MGI:MGI:5607239|PMID:18400107
Biological Process	GO:0007566	embryo implantation	EMP2	IMP		Human	PMID:16487956
Biological Process	GO:0007566	embryo implantation	Emp2	IMP		Mouse	MGI:MGI:3628891|PMID:16487956
Biological Process	GO:0060136	embryonic process involved in female pregnancy	Emp2	IMP		Mouse	MGI:MGI:5908305|PMID:28295343
Biological Process	GO:0060914	heart formation	Emp2	IMP		Mouse	MGI:MGI:6443292|PMID:30773261
Biological Process	GO:0001765	membrane raft assembly	Emp2	IDA		Mouse	MGI:MGI:3047005|PMID:14978215
Biological Process	GO:0001787	natural killer cell proliferation	Emp2	IMP		Mouse	MGI:MGI:5908305|PMID:28295343
Biological Process	GO:1990266	neutrophil migration	Emp2	IMP		Mouse	MGI:MGI:6452531|PMID:31550239
Biological Process	GO:0044854	plasma membrane raft assembly	Emp2	IMP		Mouse	MGI:MGI:6452531|PMID:31550239
Biological Process	GO:0045766	positive regulation of angiogenesis	Emp2	IMP		Mouse	MGI:MGI:5908305|PMID:28295343
Biological Process	GO:0062043	positive regulation of cardiac epithelial to mesenchymal transition	Emp2	IMP		Mouse	MGI:MGI:6443292|PMID:30773261
Biological Process	GO:0008284	positive regulation of cell population proliferation	EMP2	IMP		Human	PMID:24814193
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	EMP2	IDA		Human	PMID:16216233
Biological Process	GO:2001046	positive regulation of integrin-mediated signaling pathway	EMP2	IDA		Human	PMID:16216233
Biological Process	GO:2001046	positive regulation of integrin-mediated signaling pathway	Emp2	IMP		Mouse	PMID:16216233
Biological Process	GO:0034394	protein localization to cell surface	EMP2	IMP		Human	PMID:16216233
Biological Process	GO:0034394	protein localization to cell surface	Emp2	IMP		Mouse	MGI:MGI:6452531|PMID:31550239
Biological Process	GO:0072659	protein localization to plasma membrane	Emp2	IDA		Mouse	MGI:MGI:5605959|PMID:12189152
Biological Process	GO:0045765	regulation of angiogenesis	EMP2	IDA		Human	PMID:23334331
Biological Process	GO:0045765	regulation of angiogenesis	EMP2	IMP		Human	PMID:23439602
Biological Process	GO:0001952	regulation of cell-matrix adhesion	Emp2	IDA		Mouse	MGI:MGI:5605959|PMID:12189152
Biological Process	GO:0010594	regulation of endothelial cell migration	EMP2	IDA		Human	PMID:23334331
Biological Process	GO:0003093	regulation of glomerular filtration	EMP2	IDA		Human	PMID:24814193
Biological Process	GO:0003093	regulation of glomerular filtration	emp2	IMP		Zfish	PMID:24814193|ZFIN:ZDB-PUB-140513-5
Biological Process	GO:0043549	regulation of kinase activity	EMP2	IDA		Human	PMID:18469192
Biological Process	GO:2001212	regulation of vasculogenesis	EMP2	IDA		Human	PMID:23334331
Biological Process	GO:0001913	T cell mediated cytotoxicity	Emp2	IDA		Mouse	MGI:MGI:5605955|PMID:12763482

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern