Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EN1
  • Mouse genes En1
  • Rat genes En1
  • Zfish genes en1a,en1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set En1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	EN1	IDA		Human	PMID:21672318
Molecular Function	GO:0005515	protein binding	En1	IPI	PR:Q8VIJ6	Mouse	PMID:23863478
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	EN1	IDA		Human	PMID:21672318
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	EN1	IDA		Human	PMID:28473536
Cellular Component	GO:0016020	membrane	En1	IDA		Rat	PMID:9169834|RGD:5687201
Cellular Component	GO:0005634	nucleus	EN1	IDA		Human	PMID:24399192
Cellular Component	GO:0005634	nucleus	En1	IDA		Rat	PMID:9169834|RGD:5687201
Biological Process	GO:0008344	adult locomotory behavior	En1	IMP		Mouse	MGI:MGI:3697962|PMID:17267560
Biological Process	GO:0060385	axonogenesis involved in innervation	en1a	IGI	ZFIN:ZDB-MRPHLNO-171117-11,ZFIN:ZDB-MRPHLNO-171117-7,ZFIN:ZDB-MRPHLNO-171117-9	Zfish	PMID:28807781
Biological Process	GO:0060385	axonogenesis involved in innervation	en1a	IGI	ZFIN:ZDB-MRPHLNO-171117-10,ZFIN:ZDB-MRPHLNO-171117-11,ZFIN:ZDB-MRPHLNO-171117-6,ZFIN:ZDB-MRPHLNO-171117-7,ZFIN:ZDB-MRPHLNO-171117-8,ZFIN:ZDB-MRPHLNO-171117-9	Zfish	PMID:28807781
Biological Process	GO:0060385	axonogenesis involved in innervation	en1b	IGI	ZFIN:ZDB-MRPHLNO-171117-10,ZFIN:ZDB-MRPHLNO-171117-11,ZFIN:ZDB-MRPHLNO-171117-6,ZFIN:ZDB-MRPHLNO-171117-7,ZFIN:ZDB-MRPHLNO-171117-8,ZFIN:ZDB-MRPHLNO-171117-9	Zfish	PMID:28807781
Biological Process	GO:0060385	axonogenesis involved in innervation	en1b	IGI	ZFIN:ZDB-MRPHLNO-171117-11,ZFIN:ZDB-MRPHLNO-171117-7,ZFIN:ZDB-MRPHLNO-171117-9	Zfish	PMID:28807781
Biological Process	GO:0021549	cerebellum development	En1	IGI	UniProtKB:P04426	Mouse	MGI:MGI:82938|PMID:8848044
Biological Process	GO:0071542	dopaminergic neuron differentiation	En1	IGI	MGI:MGI:95390	Mouse	PMID:15175251
Biological Process	GO:0071542	dopaminergic neuron differentiation	En1	IGI	MGI:MGI:95390	Mouse	PMID:15340832
Biological Process	GO:0009953	dorsal/ventral pattern formation	En1	IMP	MGI:MGI:1857163	Mouse	PMID:9362463
Biological Process	GO:0009953	dorsal/ventral pattern formation	En1	IMP	MGI:MGI:1857163	Mouse	PMID:8684466
Biological Process	GO:0042756	drinking behavior	En1	IMP		Mouse	MGI:MGI:3697962|PMID:17267560
Biological Process	GO:1990403	embryonic brain development	En1	IMP		Mouse	MGI:MGI:75252|PMID:7624797
Biological Process	GO:0035115	embryonic forelimb morphogenesis	En1	IGI	MGI:MGI:98961	Mouse	PMID:9362463
Biological Process	GO:0030326	embryonic limb morphogenesis	En1	IMP		Mouse	MGI:MGI:75252|PMID:7624797
Biological Process	GO:0030326	embryonic limb morphogenesis	En1	IGI	MGI:MGI:1329040	Mouse	PMID:15242796
Biological Process	GO:0030326	embryonic limb morphogenesis	En1	IMP	MGI:MGI:1857163	Mouse	PMID:8684466
Biological Process	GO:0030326	embryonic limb morphogenesis	En1	IGI	MGI:MGI:98961	Mouse	PMID:15242796
Biological Process	GO:0030902	hindbrain development	En1	IGI	MGI:MGI:95390	Mouse	PMID:15607945
Biological Process	GO:0060173	limb development	En1	IMP	MGI:MGI:1857163	Mouse	PMID:23863478
Biological Process	GO:0030901	midbrain development	En1	IGI	UniProtKB:P04426	Mouse	MGI:MGI:82938|PMID:8848044
Biological Process	GO:0030901	midbrain development	En1	IGI	MGI:MGI:95390	Mouse	PMID:15607945
Biological Process	GO:0030901	midbrain development	En1	IGI	MGI:MGI:95390	Mouse	PMID:15175251
Biological Process	GO:0030917	midbrain-hindbrain boundary development	En1	IMP	MGI:MGI:1857163	Mouse	PMID:15607945
Biological Process	GO:0061743	motor learning	En1	IMP		Mouse	MGI:MGI:3697962|PMID:17267560
Biological Process	GO:0035264	multicellular organism growth	En1	IMP	MGI:MGI:1857163	Mouse	PMID:23863478
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	En1	IGI	UniProtKB:P09066	Mouse	MGI:MGI:3578062|PMID:15175251
Biological Process	GO:1901215	negative regulation of neuron death	En1	IMP		Mouse	MGI:MGI:3697962|PMID:17267560
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	EN1	IDA		Human	PMID:21672318
Biological Process	GO:0048666	neuron development	En1	IGI	MGI:MGI:95390	Mouse	PMID:11312297
Biological Process	GO:0048666	neuron development	En1	IMP	MGI:MGI:1857163	Mouse	PMID:23863478
Biological Process	GO:0030182	neuron differentiation	En1	IGI	MGI:MGI:95390	Mouse	PMID:15340832
Biological Process	GO:0030182	neuron differentiation	En1	IGI	MGI:MGI:95390	Mouse	PMID:15607945
Biological Process	GO:0048663	neuron fate commitment	en1b	IEP		Zfish	PMID:15215305
Biological Process	GO:0043473	pigmentation	En1	IMP	MGI:MGI:1857163	Mouse	PMID:9362463
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	En1	IDA		Mouse	PMID:9102311
Biological Process	GO:0009954	proximal/distal pattern formation	En1	IMP	MGI:MGI:1857163	Mouse	PMID:8684466
Biological Process	GO:0009954	proximal/distal pattern formation	En1	IMP	MGI:MGI:1857163	Mouse	PMID:9362463
Biological Process	GO:0010468	regulation of gene expression	En1	IMP	MGI:MGI:1857163	Mouse	PMID:23863478
Biological Process	GO:0010468	regulation of gene expression	En1	IGI	MGI:MGI:1100498	Mouse	PMID:23863478
Biological Process	GO:0042220	response to cocaine	En1	IEP		Rat	PMID:17070804|RGD:5687200
Biological Process	GO:0035176	social behavior	En1	IMP		Mouse	MGI:MGI:3697962|PMID:17267560

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern