Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EN2
  • Mouse genes En2
  • Rat genes En2
  • Zfish genes en2a,en2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set En2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	EN2	IDA		Human	PMID:28473536
Cellular Component	GO:0001650	fibrillar center	EN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	En2	IDA		Rat	PMID:9169834|RGD:5687201
Cellular Component	GO:0005730	nucleolus	EN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	EN2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	En2	IDA		Rat	PMID:9169834|RGD:5687201
Biological Process	GO:0009952	anterior/posterior pattern specification	en2a	IGI	ZFIN:ZDB-GENE-980526-40,ZFIN:ZDB-GENE-990415-72	Zfish	PMID:12917294
Biological Process	GO:0009952	anterior/posterior pattern specification	en2b	IGI	ZFIN:ZDB-GENE-980526-167,ZFIN:ZDB-GENE-990415-72	Zfish	PMID:12917294
Biological Process	GO:0060561	apoptotic process involved in morphogenesis	en2a	IGI	ZFIN:ZDB-MRPHLNO-060930-2,ZFIN:ZDB-MRPHLNO-120207-2	Zfish	PMID:22223680
Biological Process	GO:0060385	axonogenesis involved in innervation	en2a	IGI	ZFIN:ZDB-MRPHLNO-171117-11,ZFIN:ZDB-MRPHLNO-171117-7,ZFIN:ZDB-MRPHLNO-171117-9	Zfish	PMID:28807781
Biological Process	GO:0060385	axonogenesis involved in innervation	en2a	IGI	ZFIN:ZDB-MRPHLNO-171117-10,ZFIN:ZDB-MRPHLNO-171117-11,ZFIN:ZDB-MRPHLNO-171117-6,ZFIN:ZDB-MRPHLNO-171117-7,ZFIN:ZDB-MRPHLNO-171117-8,ZFIN:ZDB-MRPHLNO-171117-9	Zfish	PMID:28807781
Biological Process	GO:0001708	cell fate specification	en2a	IGI	ZFIN:ZDB-GENE-980526-40,ZFIN:ZDB-GENE-990415-72	Zfish	PMID:12917294
Biological Process	GO:0001708	cell fate specification	en2b	IGI	ZFIN:ZDB-GENE-980526-167,ZFIN:ZDB-GENE-990415-72	Zfish	PMID:12917294
Biological Process	GO:0071542	dopaminergic neuron differentiation	En2	IGI	MGI:MGI:95389	Mouse	PMID:15175251
Biological Process	GO:0071542	dopaminergic neuron differentiation	En2	IGI	MGI:MGI:95389	Mouse	PMID:15340832
Biological Process	GO:1990403	embryonic brain development	En2	IGI	UniProtKB:P09065	Mouse	MGI:MGI:75252|PMID:7624797
Biological Process	GO:0030902	hindbrain development	En2	IGI	MGI:MGI:95389	Mouse	PMID:15607945
Biological Process	GO:0030901	midbrain development	En2	IGI	MGI:MGI:95389	Mouse	PMID:15175251
Biological Process	GO:0030901	midbrain development	En2	IGI	MGI:MGI:95389	Mouse	PMID:15607945
Biological Process	GO:0030901	midbrain development	en2a	IGI	ZFIN:ZDB-GENE-980526-40,ZFIN:ZDB-GENE-990415-72	Zfish	PMID:12917294
Biological Process	GO:0030901	midbrain development	en2b	IGI	ZFIN:ZDB-GENE-980526-167,ZFIN:ZDB-GENE-990415-72	Zfish	PMID:12917294
Biological Process	GO:0030917	midbrain-hindbrain boundary development	en2a	IGI	ZFIN:ZDB-MRPHLNO-060930-2,ZFIN:ZDB-MRPHLNO-060930-3	Zfish	PMID:11477690
Biological Process	GO:0030917	midbrain-hindbrain boundary development	en2b	IGI	ZFIN:ZDB-MRPHLNO-060930-2,ZFIN:ZDB-MRPHLNO-060930-3	Zfish	PMID:11477690
Biological Process	GO:0021555	midbrain-hindbrain boundary morphogenesis	en2a	IGI	ZFIN:ZDB-GENE-980526-167,ZFIN:ZDB-MRPHLNO-120207-2	Zfish	PMID:22223680
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	En2	IGI	UniProtKB:P09065	Mouse	MGI:MGI:3578062|PMID:15175251
Biological Process	GO:0048666	neuron development	En2	IGI	MGI:MGI:95389	Mouse	PMID:11312297
Biological Process	GO:0030182	neuron differentiation	En2	IGI	MGI:MGI:95389	Mouse	PMID:15340832
Biological Process	GO:0030182	neuron differentiation	En2	IGI	MGI:MGI:95389	Mouse	PMID:15607945
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	En2	IDA		Mouse	PMID:9102311

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern