Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ENDOG
  • Mouse genes Endog
  • Rat genes Endog
  • Zfish genes endog
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Endog

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004520	DNA endonuclease activity	ENDOG	IMP		Human	PMID:25355512
Molecular Function	GO:0004520	DNA endonuclease activity	ENDOG	IMP		Human	PMID:29719607
Molecular Function	GO:0004520	DNA endonuclease activity	ENDOG	IMP		Human	PMID:33473107
Molecular Function	GO:0004520	DNA endonuclease activity	Endog	IDA		Mouse	MGI:MGI:6810801|PMID:32095813
Molecular Function	GO:0004520	DNA endonuclease activity	Endog	IMP		Mouse	MGI:MGI:6480170|PMID:32192768
Molecular Function	GO:0004520	DNA endonuclease activity	Endog	IMP		Mouse	MGI:MGI:5617102|PMID:25355512
Molecular Function	GO:0004536	DNA nuclease activity	Endog	IDA		Rat	PMID:16407272|RGD:9685355
Molecular Function	GO:0000287	magnesium ion binding	Endog	IDA		Mouse	MGI:MGI:6810801|PMID:32095813
Molecular Function	GO:0000287	magnesium ion binding	Endog	IDA		Mouse	MGI:MGI:6480170|PMID:32192768
Molecular Function	GO:0005515	protein binding	ENDOG	IPI	UniProtKB:Q8WW22	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	Endog	IPI	UniProtKB:P61981	Mouse	MGI:MGI:6504770|PMID:33473107
Molecular Function	GO:0042803	protein homodimerization activity	Endog	IMP		Mouse	MGI:MGI:6480170|PMID:32192768
Cellular Component	GO:0005829	cytosol	Endog	IDA		Rat	PMID:16407272|RGD:9685355
Cellular Component	GO:0005739	mitochondrion	ENDOG	IDA		Human	PMID:33473107
Cellular Component	GO:0005739	mitochondrion	Endog	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Endog	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Endog	IDA		Rat	PMID:16407272|RGD:9685355
Cellular Component	GO:0005739	mitochondrion	Endog	IDA		Rat	PMID:23006905|RGD:9685394
Cellular Component	GO:0005634	nucleus	Endog	IDA		Rat	PMID:16407272|RGD:9685355
Cellular Component	GO:0005634	nucleus	Endog	IDA		Rat	PMID:23006905|RGD:9685394
Cellular Component	GO:0043204	perikaryon	Endog	IDA		Rat	PMID:16689664|RGD:8655990
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Endog	IDA		Rat	PMID:23006905|RGD:9685394
Biological Process	GO:0007568	aging	Endog	IEP		Rat	PMID:15650125|RGD:9685359
Biological Process	GO:0006309	apoptotic DNA fragmentation	Endog	IMP	MGI:MGI:3034030	Mouse	PMID:14663139
Biological Process	GO:0006309	apoptotic DNA fragmentation	Endog	IMP	MGI:MGI:3514265	Mouse	PMID:14663139
Biological Process	GO:0071277	cellular response to calcium ion	Endog	IEP		Rat	PMID:12582256|RGD:9685368
Biological Process	GO:0071333	cellular response to glucose stimulus	Endog	IEP		Rat	PMID:23192364|RGD:9685390
Biological Process	GO:0071456	cellular response to hypoxia	Endog	IEP		Rat	PMID:17379825|RGD:9685412
Biological Process	GO:0034599	cellular response to oxidative stress	Endog	IEP		Rat	PMID:16407272|RGD:9685355
Biological Process	GO:0006974	DNA damage response	ENDOG	IMP		Human	PMID:33473107
Biological Process	GO:0001701	in utero embryonic development	Endog	IMP	MGI:MGI:3034030	Mouse	PMID:14663139
Biological Process	GO:0001701	in utero embryonic development	Endog	IMP	MGI:MGI:3514265	Mouse	PMID:14663139
Biological Process	GO:0032043	mitochondrial DNA catabolic process	ENDOG	IMP		Human	PMID:29719607
Biological Process	GO:0032007	negative regulation of TOR signaling	ENDOG	IMP		Human	PMID:33473107
Biological Process	GO:0032007	negative regulation of TOR signaling	Endog	IMP		Mouse	MGI:MGI:6504770|PMID:33473107
Biological Process	GO:1902512	positive regulation of apoptotic DNA fragmentation	Endog	IMP		Rat	PMID:16407272|RGD:9685355
Biological Process	GO:0043065	positive regulation of apoptotic process	Endog	IMP	MGI:MGI:3034030	Mouse	PMID:14663139
Biological Process	GO:0043065	positive regulation of apoptotic process	Endog	IMP	MGI:MGI:3514265	Mouse	PMID:14663139
Biological Process	GO:0010508	positive regulation of autophagy	ENDOG	IMP		Human	PMID:33473107
Biological Process	GO:0010508	positive regulation of autophagy	Endog	IMP		Mouse	MGI:MGI:6504770|PMID:33473107
Biological Process	GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death	Endog	IMP		Rat	PMID:20594982|RGD:9685387
Biological Process	GO:0090297	positive regulation of mitochondrial DNA replication	ENDOG	IMP		Human	PMID:29719607
Biological Process	GO:0046677	response to antibiotic	Endog	IMP	MGI:MGI:3514265	Mouse	PMID:14663139
Biological Process	GO:0046677	response to antibiotic	Endog	IMP	MGI:MGI:3034030	Mouse	PMID:14663139
Biological Process	GO:0032355	response to estradiol	Endog	IEP		Rat	PMID:24121025|RGD:9685366
Biological Process	GO:0009612	response to mechanical stimulus	Endog	IEP		Rat	PMID:21540338|RGD:9685411
Biological Process	GO:0034612	response to tumor necrosis factor	Endog	IMP	MGI:MGI:3034030	Mouse	PMID:14663139
Biological Process	GO:0034612	response to tumor necrosis factor	Endog	IMP	MGI:MGI:3514265	Mouse	PMID:14663139

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern