Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ENO1
  • Mouse genes Eno1
  • Rat genes Eno1,Eno1-ps1
  • Zfish genes eno1a,eno1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eno1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	ENO1	HDA		Human	PMID:25468996
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ENO1	IDA		Human	PMID:2005901
Molecular Function	GO:0019899	enzyme binding	Eno1	IPI	UniProtKB:P07323	Rat	PMID:14499952|RGD:12793007
Molecular Function	GO:0019899	enzyme binding	Eno1	IPI	UniProtKB:P07323	Rat	PMID:15041191|RGD:2302788
Molecular Function	GO:0051020	GTPase binding	ENO1	IPI	UniProtKB:P32455	Human	PMID:24337748
Molecular Function	GO:0031072	heat shock protein binding	Eno1	IPI	RGD:621725	Rat	PMID:21958194|RGD:10059326
Molecular Function	GO:0042802	identical protein binding	Eno1	IPI	RGD:2553	Rat	PMID:7086434|RGD:2302787
Molecular Function	GO:0004634	phosphopyruvate hydratase activity	ENO1	IDA		Human	PMID:29775581
Molecular Function	GO:0004634	phosphopyruvate hydratase activity	ENO1	IMP		Human	PMID:3529090
Molecular Function	GO:0004634	phosphopyruvate hydratase activity	Eno1	IMP		Mouse	PMID:30679508
Molecular Function	GO:0004634	phosphopyruvate hydratase activity	Eno1	IDA		Mouse	PMID:7323947
Molecular Function	GO:0004634	phosphopyruvate hydratase activity	Eno1	IDA		Rat	PMID:7964722|RGD:12792993
Molecular Function	GO:0005515	protein binding	ENO1	IPI	UniProtKB:P00747	Human	PMID:12666133
Molecular Function	GO:0005515	protein binding	ENO1	IPI	UniProtKB:P63104	Human	PMID:15161933
Molecular Function	GO:0005515	protein binding	ENO1	IPI	UniProtKB:P42858	Human	PMID:17500595
Molecular Function	GO:0005515	protein binding	ENO1	IPI	UniProtKB:P22303	Human	PMID:18194455
Molecular Function	GO:0005515	protein binding	ENO1	IPI	UniProtKB:P00747	Human	PMID:19433310
Molecular Function	GO:0005515	protein binding	ENO1	IPI	UniProtKB:P12004	Human	PMID:20849852
Molecular Function	GO:0005515	protein binding	ENO1	IPI	UniProtKB:O75952-1	Human	PMID:21274509
Molecular Function	GO:0005515	protein binding	ENO1	IPI	UniProtKB:P21754	Human	PMID:23355646
Molecular Function	GO:0005515	protein binding	ENO1	IPI	UniProtKB:Q05996	Human	PMID:23355646
Molecular Function	GO:0005515	protein binding	ENO1	IPI	UniProtKB:Q12836	Human	PMID:23355646
Molecular Function	GO:0005515	protein binding	ENO1	IPI	UniProtKB:P63104	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	ENO1	IPI	UniProtKB:Q8WZ42	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	ENO1	IPI	UniProtKB:Q9NX76	Human	PMID:28813417
Molecular Function	GO:0005515	protein binding	ENO1	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Eno1	IPI	PR:Q8C042	Mouse	PMID:23446454
Molecular Function	GO:0005515	protein binding	Eno1	IPI	UniProtKB:Q5VU43-11	Rat	PMID:21569246|RGD:10047194
Molecular Function	GO:0005515	protein binding	Eno1	IPI	UniProtKB:Q01177	Rat	PMID:7964722|RGD:12792993
Molecular Function	GO:0042803	protein homodimerization activity	ENO1	IDA		Human	PMID:3529090
Molecular Function	GO:0042803	protein homodimerization activity	Eno1	IDA		Rat	PMID:7964722|RGD:12792993
Molecular Function	GO:0044877	protein-containing complex binding	Eno1	IDA		Rat	PMID:15041191|RGD:2302788
Molecular Function	GO:0044877	protein-containing complex binding	Eno1	IDA		Rat	PMID:7086434|RGD:2302787
Molecular Function	GO:0003723	RNA binding	ENO1	HDA		Human	PMID:22658674
Molecular Function	GO:0003723	RNA binding	Eno1	IDA		Mouse	PMID:21936910
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ENO1	IDA		Human	PMID:2005901
Molecular Function	GO:0003714	transcription corepressor activity	ENO1	IDA		Human	PMID:11134351
Molecular Function	GO:0001222	transcription corepressor binding	ENO1	IPI	UniProtKB:P0DI82	Human	PMID:11134351
Cellular Component	GO:0005938	cell cortex	ENO1	IDA		Human	PMID:19433310
Cellular Component	GO:0005938	cell cortex	Eno1	IDA		Rat	PMID:19433310|RGD:12792998
Cellular Component	GO:0009986	cell surface	ENO1	IDA		Human	PMID:12666133
Cellular Component	GO:0009986	cell surface	ENO1	IDA		Human	PMID:19433310
Cellular Component	GO:0009986	cell surface	Eno1	IDA		Mouse	PMID:17690254
Cellular Component	GO:0009986	cell surface	Eno1	IDA		Rat	PMID:7964722|RGD:12792993
Cellular Component	GO:0005737	cytoplasm	ENO1	IDA		Human	GO_REF:0000054
Cellular Component	GO:0005737	cytoplasm	ENO1	IDA		Human	PMID:15459207
Cellular Component	GO:0005737	cytoplasm	ENO1	IDA		Human	PMID:25468996
Cellular Component	GO:0005737	cytoplasm	Eno1	IDA		Rat	PMID:15459207|RGD:12793039
Cellular Component	GO:0005829	cytosol	ENO1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	ENO1	IDA		Human	PMID:12666133
Cellular Component	GO:0005829	cytosol	ENO1	IDA		Human	PMID:19433310
Cellular Component	GO:0005829	cytosol	Eno1	IDA		Rat	PMID:14499952|RGD:12793007
Cellular Component	GO:0070062	extracellular exosome	ENO1	HDA		Human	PMID:11487543
Cellular Component	GO:0070062	extracellular exosome	ENO1	HDA		Human	PMID:12519789
Cellular Component	GO:0070062	extracellular exosome	ENO1	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	ENO1	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	ENO1	HDA		Human	PMID:21362503
Cellular Component	GO:0070062	extracellular exosome	ENO1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	ENO1	HDA		Human	PMID:16502470
Cellular Component	GO:0005615	extracellular space	ENO1	HDA		Human	PMID:22664934
Cellular Component	GO:0005615	extracellular space	ENO1	HDA		Human	PMID:23580065
Cellular Component	GO:0030426	growth cone	Eno1	IDA		Rat	PMID:19433310|RGD:12792998
Cellular Component	GO:0016020	membrane	ENO1	IDA		Human	PMID:19433310
Cellular Component	GO:0016020	membrane	ENO1	HDA		Human	PMID:19946888
Cellular Component	GO:0045121	membrane raft	Eno1	IDA		Rat	PMID:14499952|RGD:12793007
Cellular Component	GO:0043209	myelin sheath	Eno1	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0005640	nuclear outer membrane	ENO1	IDA		Human	PMID:11134351
Cellular Component	GO:0005634	nucleus	ENO1	HDA		Human	PMID:21630459
Cellular Component	GO:0000015	phosphopyruvate hydratase complex	ENO1	IDA		Human	PMID:3529090
Cellular Component	GO:0000015	phosphopyruvate hydratase complex	Eno1	IDA		Rat	PMID:15041191|RGD:2302788
Cellular Component	GO:0005886	plasma membrane	ENO1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ENO1	IDA		Human	PMID:12666133
Cellular Component	GO:0005886	plasma membrane	Eno1	IDA		Rat	PMID:7964722|RGD:12792993
Cellular Component	GO:0097060	synaptic membrane	Eno1	IDA		Rat	PMID:15041191|RGD:2302788
Biological Process	GO:0061621	canonical glycolysis	ENO1	IDA		Human	PMID:29775581
Biological Process	GO:0061621	canonical glycolysis	ENO1	IMP		Human	PMID:3529090
Biological Process	GO:0061621	canonical glycolysis	Eno1	IDA		Rat	PMID:15041191|RGD:2302788
Biological Process	GO:0071229	cellular response to acid chemical	Eno1	IDA		Mouse	PMID:17690254
Biological Process	GO:0071456	cellular response to hypoxia	Eno1	IDA		Rat	PMID:15459207|RGD:12793039
Biological Process	GO:0098761	cellular response to interleukin-7	Eno1	IDA		Mouse	PMID:29581031
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Eno1	IDA		Rat	PMID:15459207|RGD:12793039
Biological Process	GO:0006094	gluconeogenesis	Eno1	IMP		Mouse	PMID:30679508
Biological Process	GO:0006096	glycolytic process	Eno1	IDA		Rat	PMID:7964722|RGD:12792993
Biological Process	GO:0001701	in utero embryonic development	Eno1	IMP	MGI:MGI:3050549	Mouse	PMID:9626503
Biological Process	GO:0030308	negative regulation of cell growth	ENO1	IDA		Human	PMID:10082554
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ENO1	IDA		Human	PMID:10082554
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ENO1	IMP		Human	PMID:10681589
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ENO1	IDA		Human	PMID:11134351
Biological Process	GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	ENO1	IDA		Human	PMID:15459207
Biological Process	GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	ENO1	IGI	UniProtKB:Q01986	Human	PMID:15459207
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ENO1	IDA		Human	PMID:2005901
Biological Process	GO:2001171	positive regulation of ATP biosynthetic process	ENO1	IDA		Human	PMID:15459207
Biological Process	GO:2001171	positive regulation of ATP biosynthetic process	ENO1	IGI	UniProtKB:Q01986	Human	PMID:15459207
Biological Process	GO:0051099	positive regulation of binding	Eno1	IMP		Mouse	PMID:17690254
Biological Process	GO:0045933	positive regulation of muscle contraction	ENO1	IGI	UniProtKB:Q01986	Human	PMID:15459207
Biological Process	GO:0010756	positive regulation of plasminogen activation	ENO1	IMP		Human	PMID:12666133
Biological Process	GO:0009615	response to virus	ENO1	IEP		Human	PMID:16548883

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern