Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ENPP1
  • Mouse genes Enpp1
  • Rat genes Enpp1
  • Zfish genes enpp1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Enpp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	ENPP1	IDA		Human	PMID:7830796
Molecular Function	GO:0005509	calcium ion binding	Enpp1	IDA		Mouse	MGI:MGI:5448569|PMID:23027977
Molecular Function	GO:0106177	cyclic-GMP-AMP hydrolase activity	ENPP1	IDA		Human	PMID:25344812
Molecular Function	GO:0106177	cyclic-GMP-AMP hydrolase activity	Enpp1	IMP		Mouse	MGI:MGI:6294165|PMID:25344812
Molecular Function	GO:0106177	cyclic-GMP-AMP hydrolase activity	Enpp1	IDA		Mouse	MGI:MGI:6294158|PMID:30356045
Molecular Function	GO:0004551	dinucleotide phosphatase activity	ENPP1	IDA		Human	PMID:12746903
Molecular Function	GO:0004551	dinucleotide phosphatase activity	Enpp1	IDA		Mouse	MGI:MGI:5448569|PMID:23027977
Molecular Function	GO:0004527	exonuclease activity	ENPP1	IDA		Human	PMID:22285541
Molecular Function	GO:0042802	identical protein binding	Enpp1	IPI	UniProtKB:P06802	Mouse	MGI:MGI:5925671|PMID:23041369
Molecular Function	GO:0005158	insulin receptor binding	ENPP1	IDA		Human	PMID:7830796
Molecular Function	GO:0047429	nucleoside triphosphate diphosphatase activity	ENPP1	IDA		Human	PMID:10513816
Molecular Function	GO:0047429	nucleoside triphosphate diphosphatase activity	ENPP1	IDA		Human	PMID:11159191
Molecular Function	GO:0047429	nucleoside triphosphate diphosphatase activity	ENPP1	IDA		Human	PMID:25344812
Molecular Function	GO:0047429	nucleoside triphosphate diphosphatase activity	ENPP1	IDA		Human	PMID:7830796
Molecular Function	GO:0047429	nucleoside triphosphate diphosphatase activity	Enpp1	IDA		Mouse	MGI:MGI:6294158|PMID:30356045
Molecular Function	GO:0016791	phosphatase activity	ENPP1	IDA		Human	PMID:28592560
Molecular Function	GO:0016791	phosphatase activity	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:23798568
Molecular Function	GO:0016791	phosphatase activity	Enpp1	IDA		Mouse	PMID:15096095
Molecular Function	GO:0016791	phosphatase activity	Enpp1	IDA		Mouse	PMID:12533192
Molecular Function	GO:0016791	phosphatase activity	Enpp1	IDA		Mouse	PMID:12817751
Molecular Function	GO:0016791	phosphatase activity	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:25260930
Molecular Function	GO:0004528	phosphodiesterase I activity	ENPP1	IDA		Human	PMID:27467858
Molecular Function	GO:0004528	phosphodiesterase I activity	Enpp1	IDA		Mouse	MGI:MGI:67562|PMID:1647027
Molecular Function	GO:0004528	phosphodiesterase I activity	Enpp1	IDA		Mouse	PMID:15096095
Molecular Function	GO:0004528	phosphodiesterase I activity	Enpp1	IMP	MGI:MGI:6402836	Mouse	PMID:24770645
Molecular Function	GO:0004528	phosphodiesterase I activity	Enpp1	IDA		Rat	PMID:17187902|RGD:13204714
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	Enpp1	IDA		Mouse	PMID:27406238
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	Enpp1	IDA		Mouse	PMID:12533192
Molecular Function	GO:0005515	protein binding	ENPP1	IPI	UniProtKB:P06213	Human	PMID:11289049
Molecular Function	GO:0042803	protein homodimerization activity	ENPP1	IDA		Human	PMID:28964717
Molecular Function	GO:0042803	protein homodimerization activity	ENPP1	IDA		Human	PMID:7830796
Molecular Function	GO:0042803	protein homodimerization activity	Enpp1	IDA		Mouse	PMID:12533192
Molecular Function	GO:0008270	zinc ion binding	Enpp1	IDA		Mouse	MGI:MGI:5448569|PMID:23027977
Molecular Function	GO:0008270	zinc ion binding	Enpp1	IDA		Mouse	MGI:MGI:6294158|PMID:30356045
Cellular Component	GO:0097440	apical dendrite	Enpp1	IDA		Rat	PMID:17046728|RGD:1601061
Cellular Component	GO:0097441	basal dendrite	Enpp1	IDA		Rat	PMID:17046728|RGD:1601061
Cellular Component	GO:0044297	cell body	Enpp1	IDA		Rat	PMID:22086174|RGD:13204715
Cellular Component	GO:0042995	cell projection	Enpp1	IDA		Rat	PMID:22086174|RGD:13204715
Cellular Component	GO:0009986	cell surface	ENPP1	IDA		Human	PMID:10513816
Cellular Component	GO:0009986	cell surface	Enpp1	IDA		Mouse	MGI:MGI:3777547|PMID:8223581
Cellular Component	GO:0009986	cell surface	Enpp1	IDA		Mouse	PMID:23169635
Cellular Component	GO:0005576	extracellular region	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:12817751
Cellular Component	GO:0005615	extracellular space	ENPP1	IDA		Human	PMID:11159191
Cellular Component	GO:0005615	extracellular space	Enpp1	IDA		Mouse	MGI:MGI:3777547|PMID:8223581
Cellular Component	GO:0005765	lysosomal membrane	ENPP1	HDA		Human	PMID:17897319
Cellular Component	GO:0016020	membrane	Enpp1	IDA		Mouse	MGI:MGI:67562|PMID:1647027
Cellular Component	GO:0043005	neuron projection	Enpp1	IDA		Rat	PMID:17046728|RGD:1601061
Cellular Component	GO:0043025	neuronal cell body	Enpp1	IDA		Rat	PMID:17046728|RGD:1601061
Cellular Component	GO:0005886	plasma membrane	ENPP1	IDA		Human	PMID:25644539
Cellular Component	GO:0005886	plasma membrane	ENPP1	IDA		Human	PMID:10513816
Cellular Component	GO:0005886	plasma membrane	ENPP1	IDA		Human	PMID:27467858
Cellular Component	GO:0005886	plasma membrane	Enpp1	IDA		Mouse	MGI:MGI:69421|PMID:3104326
Cellular Component	GO:0005886	plasma membrane	Enpp1	IDA		Mouse	PMID:12533192
Cellular Component	GO:0005886	plasma membrane	Enpp1	IDA		Rat	PMID:17187902|RGD:13204714
Cellular Component	GO:0005886	plasma membrane	Enpp1	IDA		Rat	PMID:19474315|RGD:8554250
Cellular Component	GO:0045202	synapse	Enpp1	IDA		Rat	PMID:17187902|RGD:13204714
Biological Process	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process	ENPP1	IDA		Human	PMID:7830796
Biological Process	GO:0060612	adipose tissue development	Enpp1	IMP	MGI:MGI:5607149	Mouse	PMID:31730234
Biological Process	GO:0060612	adipose tissue development	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:25368121
Biological Process	GO:0008344	adult locomotory behavior	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:26624227
Biological Process	GO:0007628	adult walking behavior	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:23798568
Biological Process	GO:0007628	adult walking behavior	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:22927960
Biological Process	GO:0007628	adult walking behavior	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:25368121
Biological Process	GO:0007628	adult walking behavior	Enpp1	IMP	MGI:MGI:6402836	Mouse	PMID:24770645
Biological Process	GO:0035904	aorta development	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:26624227
Biological Process	GO:0035904	aorta development	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:22359666
Biological Process	GO:0035904	aorta development	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:28798354
Biological Process	GO:1902742	apoptotic process involved in development	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:21935678
Biological Process	GO:0060840	artery development	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:28798354
Biological Process	GO:0060840	artery development	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:24530784
Biological Process	GO:0061975	articular cartilage development	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:22359666
Biological Process	GO:0061975	articular cartilage development	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:28402956
Biological Process	GO:0061975	articular cartilage development	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:22927960
Biological Process	GO:0046034	ATP metabolic process	ENPP1	IDA		Human	PMID:25644539
Biological Process	GO:0046034	ATP metabolic process	Enpp1	IDA		Mouse	MGI:MGI:5448569|PMID:23027977
Biological Process	GO:0031103	axon regeneration	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:21935678
Biological Process	GO:0001922	B-1 B cell homeostasis	Enpp1	IMP		Mouse	PMID:23169635
Biological Process	GO:0031214	biomineral tissue development	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:25260930
Biological Process	GO:0031214	biomineral tissue development	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:22359666
Biological Process	GO:0060348	bone development	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:32980560
Biological Process	GO:0060348	bone development	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:28798354
Biological Process	GO:0098868	bone growth	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:9541520
Biological Process	GO:0030282	bone mineralization	ENPP1	IDA		Human	PMID:28652107
Biological Process	GO:0030282	bone mineralization	Enpp1	IGI	MGI:MGI:97370	Mouse	PMID:12082181
Biological Process	GO:0030282	bone mineralization	Enpp1	IMP	MGI:MGI:2183411	Mouse	PMID:12082181
Biological Process	GO:0030282	bone mineralization	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:25368121
Biological Process	GO:0030282	bone mineralization	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:15920156
Biological Process	GO:0030282	bone mineralization	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:12817751
Biological Process	GO:0030282	bone mineralization	Enpp1	IMP		Mouse	PMID:12082181
Biological Process	GO:0030282	bone mineralization	Enpp1	IGI	MGI:MGI:87983	Mouse	PMID:12082181
Biological Process	GO:0030282	bone mineralization	Enpp1	IMP	MGI:MGI:2183411	Mouse	PMID:15920156
Biological Process	GO:0030282	bone mineralization	Enpp1	IDA		Mouse	PMID:12817751
Biological Process	GO:0030282	bone mineralization	Enpp1	IGI	MGI:MGI:87983	Mouse	PMID:15920156
Biological Process	GO:0030282	bone mineralization	Enpp1	IMP	MGI:MGI:6402836	Mouse	PMID:24770645
Biological Process	GO:0030282	bone mineralization	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:21930712
Biological Process	GO:0030282	bone mineralization	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:31666661
Biological Process	GO:0030282	bone mineralization	Enpp1	IDA		Mouse	PMID:21930712
Biological Process	GO:0030282	bone mineralization	Enpp1	IMP	MGI:MGI:1856651	Mouse	PMID:12817751
Biological Process	GO:0030282	bone mineralization	Enpp1	IMP		Mouse	PMID:21930712
Biological Process	GO:0030282	bone mineralization	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:26763447
Biological Process	GO:0035630	bone mineralization involved in bone maturation	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:22359666
Biological Process	GO:0035630	bone mineralization involved in bone maturation	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:25260930
Biological Process	GO:0046849	bone remodeling	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:9541520
Biological Process	GO:0046849	bone remodeling	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:10024383
Biological Process	GO:0045453	bone resorption	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:28798354
Biological Process	GO:0060346	bone trabecula formation	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:22359666
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IGI	MGI:MGI:97370	Mouse	PMID:24732453
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:24732453
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IMP	MGI:MGI:3045236	Mouse	PMID:24732453
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IGI	MGI:MGI:1351634	Mouse	PMID:24732453
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:28402956
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IGI	MGI:MGI:99829	Mouse	PMID:22927960
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:23717624
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IMP	MGI:MGI:1856651	Mouse	PMID:12817751
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:26624227
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:12817751
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:22359666
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:28701330
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:25260930
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:23798568
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IGI	MGI:MGI:1345284	Mouse	PMID:28704395
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:22927960
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IGI	MGI:MGI:1351634	Mouse	PMID:28592560
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IMP	MGI:MGI:6402836	Mouse	PMID:24770645
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:26763447
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:28592560
Biological Process	GO:0055074	calcium ion homeostasis	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:21490328
Biological Process	GO:0051216	cartilage development	Enpp1	IMP	MGI:MGI:6402836	Mouse	PMID:24770645
Biological Process	GO:0051216	cartilage development	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:15625282
Biological Process	GO:0051216	cartilage development	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:25260930
Biological Process	GO:0000904	cell morphogenesis involved in differentiation	Enpp1	IMP		Mouse	PMID:21930712
Biological Process	GO:0000904	cell morphogenesis involved in differentiation	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:21930712
Biological Process	GO:0008283	cell population proliferation	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:22927960
Biological Process	GO:0008283	cell population proliferation	Enpp1	IGI	MGI:MGI:99829	Mouse	PMID:22927960
Biological Process	GO:0019725	cellular homeostasis	Enpp1	IMP		Mouse	PMID:12082181
Biological Process	GO:0019725	cellular homeostasis	Enpp1	IGI	MGI:MGI:87983	Mouse	PMID:12082181
Biological Process	GO:0019725	cellular homeostasis	Enpp1	IMP	MGI:MGI:2183411	Mouse	PMID:12082181
Biological Process	GO:0019725	cellular homeostasis	Enpp1	IGI	MGI:MGI:97370	Mouse	PMID:12082181
Biological Process	GO:0071468	cellular response to acidic pH	Enpp1	IEP		Rat	PMID:26033523|RGD:13204712
Biological Process	GO:0071320	cellular response to cAMP	Enpp1	IEP		Rat	PMID:21168404|RGD:13204723
Biological Process	GO:0032869	cellular response to insulin stimulus	ENPP1	IDA		Human	PMID:17849011
Biological Process	GO:0032869	cellular response to insulin stimulus	ENPP1	IDA		Human	PMID:7830796
Biological Process	GO:0071260	cellular response to mechanical stimulus	Enpp1	IEP		Rat	PMID:24157151|RGD:13204713
Biological Process	GO:1904384	cellular response to sodium phosphate	Enpp1	IDA		Mouse	PMID:21930712
Biological Process	GO:1904384	cellular response to sodium phosphate	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:28798354
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	Enpp1	IEP		Rat	PMID:24157151|RGD:13204713
Biological Process	GO:0071529	cementum mineralization	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:31059863
Biological Process	GO:0071529	cementum mineralization	Enpp1	IDA		Mouse	PMID:31059863
Biological Process	GO:0071529	cementum mineralization	Enpp1	IGI	MGI:MGI:2153568	Mouse	PMID:31059863
Biological Process	GO:0071529	cementum mineralization	Enpp1	IGI	MGI:MGI:1915401	Mouse	PMID:31059863
Biological Process	GO:0071529	cementum mineralization	Enpp1	IMP		Mouse	PMID:31059863
Biological Process	GO:0071529	cementum mineralization	Enpp1	IMP	MGI:MGI:3608932	Mouse	PMID:31059863
Biological Process	GO:0022010	central nervous system myelination	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:21935678
Biological Process	GO:0021549	cerebellum development	Enpp1	IEP		Rat	PMID:18565716|RGD:13204724
Biological Process	GO:0021987	cerebral cortex development	Enpp1	IEP		Rat	PMID:18565716|RGD:13204724
Biological Process	GO:0038065	collagen-activated signaling pathway	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:32980560
Biological Process	GO:0042832	defense response to protozoan	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:29259245
Biological Process	GO:0008340	determination of adult lifespan	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:23798568
Biological Process	GO:0008340	determination of adult lifespan	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:28798354
Biological Process	GO:0008340	determination of adult lifespan	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:26624227
Biological Process	GO:0008340	determination of adult lifespan	Enpp1	IMP	MGI:MGI:6402836	Mouse	PMID:24770645
Biological Process	GO:0071344	diphosphate metabolic process	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:32980560
Biological Process	GO:0071344	diphosphate metabolic process	Enpp1	IDA		Mouse	PMID:31059863
Biological Process	GO:0071344	diphosphate metabolic process	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:31059863
Biological Process	GO:0071344	diphosphate metabolic process	Enpp1	IMP		Mouse	PMID:31059863
Biological Process	GO:0060350	endochondral bone morphogenesis	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:22359666
Biological Process	GO:0001958	endochondral ossification	Enpp1	IMP	MGI:MGI:6402836	Mouse	PMID:24770645
Biological Process	GO:0051649	establishment of localization in cell	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:29259245
Biological Process	GO:0051649	establishment of localization in cell	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:27959908
Biological Process	GO:0045444	fat cell differentiation	Enpp1	IMP	MGI:MGI:6402836	Mouse	PMID:24770645
Biological Process	GO:0045444	fat cell differentiation	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:25368121
Biological Process	GO:0060613	fat pad development	Enpp1	IMP	MGI:MGI:6402836	Mouse	PMID:24770645
Biological Process	GO:0006631	fatty acid metabolic process	Enpp1	IMP	MGI:MGI:5607149	Mouse	PMID:31730234
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:32980560
Biological Process	GO:0010467	gene expression	ENPP1	IDA		Human	PMID:28592560
Biological Process	GO:0010467	gene expression	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:23523568
Biological Process	GO:0010467	gene expression	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:21935678
Biological Process	GO:0010467	gene expression	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:21930712
Biological Process	GO:0010467	gene expression	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:31666661
Biological Process	GO:0010467	gene expression	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:32980560
Biological Process	GO:0010467	gene expression	Enpp1	IDA		Mouse	PMID:31059863
Biological Process	GO:0010467	gene expression	Enpp1	IDA		Mouse	PMID:21930712
Biological Process	GO:0010467	gene expression	Enpp1	IGI	MGI:MGI:109247	Mouse	PMID:24530784
Biological Process	GO:0010467	gene expression	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:23717624
Biological Process	GO:0010467	gene expression	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:28798354
Biological Process	GO:0010467	gene expression	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:24530784
Biological Process	GO:0010467	gene expression	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:15625282
Biological Process	GO:0010467	gene expression	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:12817751
Biological Process	GO:0010467	gene expression	Enpp1	IMP		Mouse	PMID:21930712
Biological Process	GO:0010467	gene expression	Enpp1	IMP		Mouse	PMID:31059863
Biological Process	GO:0010467	gene expression	Enpp1	IDA		Mouse	PMID:23169635
Biological Process	GO:0006091	generation of precursor metabolites and energy	ENPP1	IDA		Human	PMID:12746903
Biological Process	GO:0042593	glucose homeostasis	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:25368121
Biological Process	GO:0046323	glucose import	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:29259245
Biological Process	GO:0006096	glycolytic process	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:29259245
Biological Process	GO:0007507	heart development	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:26624227
Biological Process	GO:0097241	hematopoietic stem cell migration to bone marrow	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:31666661
Biological Process	GO:0021766	hippocampus development	Enpp1	IEP		Rat	PMID:18565716|RGD:13204724
Biological Process	GO:0042445	hormone metabolic process	Enpp1	IMP	MGI:MGI:5607149	Mouse	PMID:31730234
Biological Process	GO:0042445	hormone metabolic process	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:25368121
Biological Process	GO:0002381	immunoglobulin production involved in immunoglobulin-mediated immune response	Enpp1	IMP		Mouse	PMID:23169635
Biological Process	GO:0002437	inflammatory response to antigenic stimulus	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:29259245
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Enpp1	IMP		Mouse	PMID:25644539
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:27959908
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:21490328
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Enpp1	IGI	MGI:MGI:1351634	Mouse	PMID:24732453
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:23798568
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Enpp1	IDA		Mouse	PMID:21490328
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:28402956
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:26763447
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:24732453
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Enpp1	IGI	MGI:MGI:97370	Mouse	PMID:24732453
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:15625282
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Enpp1	IMP	MGI:MGI:3045236	Mouse	PMID:24732453
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Enpp1	IMP	MGI:MGI:1856651	Mouse	PMID:21490328
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:26624227
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:28652107
Biological Process	GO:0030505	inorganic diphosphate transport	ENPP1	IDA		Human	PMID:10513816
Biological Process	GO:0030505	inorganic diphosphate transport	Enpp1	IDA		Mouse	PMID:28701330
Biological Process	GO:0030505	inorganic diphosphate transport	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:28701330
Biological Process	GO:0030505	inorganic diphosphate transport	Enpp1	IMP	MGI:MGI:3614409	Mouse	PMID:28701330
Biological Process	GO:0030505	inorganic diphosphate transport	Enpp1	IGI	MGI:MGI:1345284	Mouse	PMID:28704395
Biological Process	GO:0030643	intracellular phosphate ion homeostasis	ENPP1	IDA		Human	PMID:11159191
Biological Process	GO:0001822	kidney development	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:22359666
Biological Process	GO:0001822	kidney development	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:26624227
Biological Process	GO:0002269	leukocyte activation involved in inflammatory response	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:29259245
Biological Process	GO:0036076	ligamentous ossification	Enpp1	IMP	MGI:MGI:6402836	Mouse	PMID:24770645
Biological Process	GO:0036076	ligamentous ossification	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:22927960
Biological Process	GO:0036076	ligamentous ossification	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:21935678
Biological Process	GO:0036076	ligamentous ossification	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:28798354
Biological Process	GO:0036076	ligamentous ossification	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:25260930
Biological Process	GO:0036076	ligamentous ossification	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:32980560
Biological Process	GO:0001889	liver development	Enpp1	IEP		Rat	PMID:10231554|RGD:13204733
Biological Process	GO:0060291	long-term synaptic potentiation	Enpp1	IMP	MGI:MGI:5607149	Mouse	PMID:31730234
Biological Process	GO:0030225	macrophage differentiation	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:23717624
Biological Process	GO:0010960	magnesium ion homeostasis	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:28402956
Biological Process	GO:0030318	melanocyte differentiation	ENPP1	IMP		Human	PMID:28964717
Biological Process	GO:0014004	microglia differentiation	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:23717624
Biological Process	GO:1904124	microglial cell migration	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:31666661
Biological Process	GO:0042474	middle ear morphogenesis	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:27959908
Biological Process	GO:0007005	mitochondrion organization	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:25368121
Biological Process	GO:0002009	morphogenesis of an epithelium	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:27959908
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:25260930
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:22359666
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:25368121
Biological Process	GO:0070254	mucus secretion	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:27959908
Biological Process	GO:0035264	multicellular organism growth	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:9541520
Biological Process	GO:0035264	multicellular organism growth	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:26624227
Biological Process	GO:0035264	multicellular organism growth	Enpp1	IMP	MGI:MGI:6402836	Mouse	PMID:24770645
Biological Process	GO:0046716	muscle cell cellular homeostasis	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:15625282
Biological Process	GO:0030502	negative regulation of bone mineralization	Enpp1	IMP		Mouse	MGI:MGI:5607146|PMID:25479107
Biological Process	GO:0030502	negative regulation of bone mineralization	Enpp1	IMP		Mouse	MGI:MGI:6294341|PMID:22510396
Biological Process	GO:0030502	negative regulation of bone mineralization	Enpp1	IMP		Mouse	MGI:MGI:6220772|PMID:30111653
Biological Process	GO:0030308	negative regulation of cell growth	ENPP1	IDA		Human	PMID:17849011
Biological Process	GO:0045599	negative regulation of fat cell differentiation	ENPP1	IDA		Human	PMID:17849011
Biological Process	GO:0045599	negative regulation of fat cell differentiation	Enpp1	IMP		Mouse	MGI:MGI:3777520|PMID:17849011
Biological Process	GO:0046325	negative regulation of glucose import	ENPP1	IDA		Human	PMID:17849011
Biological Process	GO:0045719	negative regulation of glycogen biosynthetic process	ENPP1	IDA		Human	PMID:11289049
Biological Process	GO:1990787	negative regulation of hh target transcription factor activity	Enpp1	IMP		Mouse	MGI:MGI:6220772|PMID:30111653
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	ENPP1	IDA		Human	PMID:17849011
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	ENPP1	IDA		Human	PMID:7830796
Biological Process	GO:0030279	negative regulation of ossification	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:9662402
Biological Process	GO:0031953	negative regulation of protein autophosphorylation	ENPP1	IDA		Human	PMID:11289049
Biological Process	GO:0051402	neuron apoptotic process	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:21935678
Biological Process	GO:0006807	nitrogen compound metabolic process	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:28798354
Biological Process	GO:0090305	nucleic acid phosphodiester bond hydrolysis	ENPP1	IDA		Human	PMID:22285541
Biological Process	GO:0009143	nucleoside triphosphate catabolic process	ENPP1	IDA		Human	PMID:10513816
Biological Process	GO:0042476	odontogenesis	Enpp1	IMP	MGI:MGI:5607149	Mouse	PMID:29533727
Biological Process	GO:0021772	olfactory bulb development	Enpp1	IEP		Rat	PMID:18565716|RGD:13204724
Biological Process	GO:0097252	oligodendrocyte apoptotic process	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:21935678
Biological Process	GO:0019634	organic phosphonate metabolic process	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:26763447
Biological Process	GO:0001503	ossification	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:27959908
Biological Process	GO:0001503	ossification	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:9662402
Biological Process	GO:0001649	osteoblast differentiation	Enpp1	IMP		Mouse	PMID:21930712
Biological Process	GO:0001649	osteoblast differentiation	Enpp1	IMP	MGI:MGI:2183411	Mouse	PMID:15920156
Biological Process	GO:0001649	osteoblast differentiation	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:21930712
Biological Process	GO:0001649	osteoblast differentiation	Enpp1	IDA		Mouse	PMID:21930712
Biological Process	GO:0030316	osteoclast differentiation	Enpp1	IMP	MGI:MGI:5607149	Mouse	PMID:29533727
Biological Process	GO:0055062	phosphate ion homeostasis	ENPP1	IDA		Human	PMID:28652107
Biological Process	GO:0055062	phosphate ion homeostasis	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:26624227
Biological Process	GO:0055062	phosphate ion homeostasis	Enpp1	IGI	MGI:MGI:87983	Mouse	PMID:12082181
Biological Process	GO:0055062	phosphate ion homeostasis	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:22359666
Biological Process	GO:0055062	phosphate ion homeostasis	Enpp1	IMP	MGI:MGI:2183411	Mouse	PMID:12082181
Biological Process	GO:0055062	phosphate ion homeostasis	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:28402956
Biological Process	GO:0055062	phosphate ion homeostasis	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:28701330
Biological Process	GO:0055062	phosphate ion homeostasis	Enpp1	IDA		Mouse	PMID:28701330
Biological Process	GO:0055062	phosphate ion homeostasis	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:23798568
Biological Process	GO:0055062	phosphate ion homeostasis	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:12817751
Biological Process	GO:0055062	phosphate ion homeostasis	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:28652107
Biological Process	GO:0055062	phosphate ion homeostasis	Enpp1	IMP		Mouse	PMID:12082181
Biological Process	GO:0055062	phosphate ion homeostasis	Enpp1	IMP	MGI:MGI:3614409	Mouse	PMID:28701330
Biological Process	GO:0055062	phosphate ion homeostasis	Enpp1	IGI	MGI:MGI:97370	Mouse	PMID:12082181
Biological Process	GO:0055062	phosphate ion homeostasis	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:21490328
Biological Process	GO:0055062	phosphate ion homeostasis	enpp1	IMP	ZFIN:ZDB-GENO-130411-6	Zfish	PMID:24906371
Biological Process	GO:0006796	phosphate-containing compound metabolic process	ENPP1	IDA		Human	PMID:10513816
Biological Process	GO:0006796	phosphate-containing compound metabolic process	ENPP1	IDA		Human	PMID:11159191
Biological Process	GO:0002317	plasma cell differentiation	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:29259245
Biological Process	GO:0035128	post-embryonic forelimb morphogenesis	Enpp1	IMP	MGI:MGI:6402836	Mouse	PMID:24770645
Biological Process	GO:0070212	protein poly-ADP-ribosylation	Enpp1	IDA		Mouse	PMID:27406238
Biological Process	GO:0030500	regulation of bone mineralization	enpp1	IMP	ZFIN:ZDB-GENO-130411-6	Zfish	PMID:25758222
Biological Process	GO:0030500	regulation of bone mineralization	enpp1	IMP	ZFIN:ZDB-GENO-130411-6	Zfish	PMID:24906371
Biological Process	GO:0033198	response to ATP	ENPP1	IDA		Human	PMID:25644539
Biological Process	GO:0002021	response to dietary excess	Enpp1	IMP	MGI:MGI:5607149	Mouse	PMID:31730234
Biological Process	GO:0002021	response to dietary excess	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:25368121
Biological Process	GO:0140459	response to Gram-positive bacterium	Enpp1	IMP		Mouse	PMID:23169635
Biological Process	GO:0010035	response to inorganic substance	ENPP1	IDA		Human	PMID:25644539
Biological Process	GO:0032868	response to insulin	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:25368121
Biological Process	GO:0033591	response to L-ascorbic acid	Enpp1	IMP		Mouse	PMID:21930712
Biological Process	GO:0033591	response to L-ascorbic acid	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:21930712
Biological Process	GO:0032026	response to magnesium ion	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:23798568
Biological Process	GO:0032026	response to magnesium ion	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:24732453
Biological Process	GO:0032026	response to magnesium ion	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:28402956
Biological Process	GO:0032026	response to magnesium ion	Enpp1	IMP	MGI:MGI:3045236	Mouse	PMID:24732453
Biological Process	GO:0032026	response to magnesium ion	Enpp1	IGI	MGI:MGI:1351634	Mouse	PMID:24732453
Biological Process	GO:0032026	response to magnesium ion	Enpp1	IGI	MGI:MGI:97370	Mouse	PMID:24732453
Biological Process	GO:0009612	response to mechanical stimulus	Enpp1	IEP		Rat	PMID:26746151|RGD:13204708
Biological Process	GO:0036119	response to platelet-derived growth factor	Enpp1	IMP	MGI:MGI:2654034	Mouse	PMID:24530784
Biological Process	GO:1904383	response to sodium phosphate	Enpp1	IMP	MGI:MGI:3045236	Mouse	PMID:24732453
Biological Process	GO:1904383	response to sodium phosphate	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:24732453
Biological Process	GO:1904383	response to sodium phosphate	Enpp1	IGI	MGI:MGI:97370	Mouse	PMID:24732453
Biological Process	GO:1904383	response to sodium phosphate	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:12817751
Biological Process	GO:1904383	response to sodium phosphate	Enpp1	IMP		Mouse	PMID:12082181
Biological Process	GO:1904383	response to sodium phosphate	Enpp1	IGI	MGI:MGI:1345284	Mouse	PMID:28704395
Biological Process	GO:1904383	response to sodium phosphate	Enpp1	IMP	MGI:MGI:2386786	Mouse	PMID:28704395
Biological Process	GO:1904383	response to sodium phosphate	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:23798568
Biological Process	GO:1904383	response to sodium phosphate	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:23523568
Biological Process	GO:1904383	response to sodium phosphate	Enpp1	IGI	MGI:MGI:97370	Mouse	PMID:28704395
Biological Process	GO:1904383	response to sodium phosphate	Enpp1	IGI	MGI:MGI:87983	Mouse	PMID:12082181
Biological Process	GO:1904383	response to sodium phosphate	Enpp1	IGI	MGI:MGI:1351634	Mouse	PMID:24732453
Biological Process	GO:0034516	response to vitamin B6	Enpp1	IGI	MGI:MGI:87983	Mouse	PMID:12082181
Biological Process	GO:0009611	response to wounding	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:24530784
Biological Process	GO:0050954	sensory perception of mechanical stimulus	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:31666661
Biological Process	GO:0007605	sensory perception of sound	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:27959908
Biological Process	GO:0050951	sensory perception of temperature stimulus	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:31666661
Biological Process	GO:0030730	sequestering of triglyceride	ENPP1	IDA		Human	PMID:17849011
Biological Process	GO:0043588	skin development	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:28798354
Biological Process	GO:0007224	smoothened signaling pathway	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:32980560
Biological Process	GO:0021510	spinal cord development	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:21935678
Biological Process	GO:0021510	spinal cord development	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:31666661
Biological Process	GO:0021510	spinal cord development	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:23717624
Biological Process	GO:0021756	striatum development	Enpp1	IEP		Rat	PMID:18565716|RGD:13204724
Biological Process	GO:0030217	T cell differentiation	Enpp1	IMP		Mouse	PMID:23169635
Biological Process	GO:0034505	tooth mineralization	Enpp1	IMP	MGI:MGI:5607149	Mouse	PMID:29533727
Biological Process	GO:0032609	type II interferon production	Enpp1	IMP		Mouse	PMID:23169635
Biological Process	GO:1904738	vascular associated smooth muscle cell migration	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:24530784
Biological Process	GO:1990874	vascular associated smooth muscle cell proliferation	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:24530784
Biological Process	GO:0001570	vasculogenesis	Enpp1	IMP	MGI:MGI:2385534	Mouse	PMID:25260930
Biological Process	GO:0070640	vitamin D3 metabolic process	Enpp1	IMP	MGI:MGI:1857079	Mouse	PMID:28798354
Biological Process	GO:0016055	Wnt signaling pathway	Enpp1	IMP	MGI:MGI:3785162	Mouse	PMID:32980560

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern