Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ENPP2
  • Mouse genes Enpp2
  • Rat genes Enpp2
  • Zfish genes enpp2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Enpp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity	Enpp2	IDA		Mouse	PMID:15096095
Molecular Function	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity	Enpp2	IDA		Rat	PMID:24747415|RGD:9685414
Molecular Function	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity	enpp2	IDA		Zfish	PMID:30629186
Molecular Function	GO:0005509	calcium ion binding	ENPP2	IDA		Human	PMID:26371182
Molecular Function	GO:0005509	calcium ion binding	Enpp2	IDA		Mouse	MGI:MGI:5050048|PMID:21240269
Molecular Function	GO:0005509	calcium ion binding	Enpp2	IDA		Rat	PMID:21240271|RGD:8553522
Molecular Function	GO:0004622	lysophospholipase activity	ENPP2	IDA		Human	PMID:12354767
Molecular Function	GO:0004622	lysophospholipase activity	ENPP2	IDA		Human	PMID:14500380
Molecular Function	GO:0004622	lysophospholipase activity	ENPP2	IDA		Human	PMID:15280042
Molecular Function	GO:0004622	lysophospholipase activity	ENPP2	IDA		Human	PMID:21240271
Molecular Function	GO:0004622	lysophospholipase activity	ENPP2	IDA		Human	PMID:21393252
Molecular Function	GO:0004622	lysophospholipase activity	ENPP2	IDA		Human	PMID:26371182
Molecular Function	GO:0004622	lysophospholipase activity	Enpp2	IDA		Mouse	MGI:MGI:5050048|PMID:21240269
Molecular Function	GO:0004622	lysophospholipase activity	Enpp2	IDA		Mouse	PMID:25596343
Molecular Function	GO:0004622	lysophospholipase activity	Enpp2	IDA		Rat	PMID:12354767|RGD:15090854
Molecular Function	GO:0004622	lysophospholipase activity	Enpp2	IDA		Rat	PMID:21240271|RGD:8553522
Molecular Function	GO:0004622	lysophospholipase activity	enpp2	IDA		Zfish	PMID:30629186
Molecular Function	GO:0004622	lysophospholipase activity	enpp2	IDA		Zfish	PMID:21971049
Molecular Function	GO:0004528	phosphodiesterase I activity	Enpp2	IMP		Rat	PMID:17307740|RGD:9685416
Molecular Function	GO:0008081	phosphoric diester hydrolase activity	enpp2	IDA		Zfish	PMID:21971049
Molecular Function	GO:0008270	zinc ion binding	ENPP2	IDA		Human	PMID:26371182
Molecular Function	GO:0008270	zinc ion binding	Enpp2	IDA		Mouse	MGI:MGI:5050048|PMID:21240269
Molecular Function	GO:0008270	zinc ion binding	Enpp2	IDA		Rat	PMID:21240271|RGD:8553522
Cellular Component	GO:0005737	cytoplasm	Enpp2	IDA		Rat	PMID:15985467|RGD:9685438
Cellular Component	GO:0005615	extracellular space	ENPP2	IDA		Human	PMID:15280042
Cellular Component	GO:0005615	extracellular space	ENPP2	IDA		Human	PMID:26371182
Cellular Component	GO:0005615	extracellular space	Enpp2	IDA		Mouse	MGI:MGI:5050048|PMID:21240269
Cellular Component	GO:0005615	extracellular space	Enpp2	IDA		Rat	PMID:12837632|RGD:1299196
Cellular Component	GO:0005615	extracellular space	Enpp2	IDA		Rat	PMID:21240271|RGD:8553522
Cellular Component	GO:0005794	Golgi apparatus	Enpp2	IDA		Rat	PMID:15985467|RGD:9685438
Biological Process	GO:0051216	cartilage development	enpp2	IMP	ZFIN:ZDB-MRPHLNO-120123-5	Zfish	PMID:27005960
Biological Process	GO:0051216	cartilage development	enpp2	IMP	ZFIN:ZDB-MRPHLNO-120123-6	Zfish	PMID:27005960
Biological Process	GO:0060326	cell chemotaxis	Enpp2	IMP		Rat	PMID:17307740|RGD:9685416
Biological Process	GO:0071276	cellular response to cadmium ion	Enpp2	IEP		Rat	PMID:24361405|RGD:9685430
Biological Process	GO:0071392	cellular response to estradiol stimulus	Enpp2	IEP		Rat	PMID:18946176|RGD:2311518
Biological Process	GO:0060271	cilium assembly	enpp2	IMP	ZFIN:ZDB-MRPHLNO-130116-2	Zfish	PMID:23095890
Biological Process	GO:0061371	determination of heart left/right asymmetry	enpp2	IMP	ZFIN:ZDB-MRPHLNO-120123-5	Zfish	PMID:23095890
Biological Process	GO:0061371	determination of heart left/right asymmetry	enpp2	IMP	ZFIN:ZDB-MRPHLNO-130116-2	Zfish	PMID:23095890
Biological Process	GO:0007368	determination of left/right symmetry	enpp2	IMP	ZFIN:ZDB-MRPHLNO-130116-2	Zfish	PMID:23095890
Biological Process	GO:0044849	estrous cycle	Enpp2	IEP		Rat	PMID:22122904|RGD:9685419
Biological Process	GO:0060217	hemangioblast cell differentiation	enpp2	IMP	ZFIN:ZDB-MRPHLNO-150827-3	Zfish	PMID:24829209
Biological Process	GO:0070121	Kupffer's vesicle development	enpp2	IMP	ZFIN:ZDB-MRPHLNO-130116-2	Zfish	PMID:23095890
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	Enpp2	IDA		Rat	PMID:12837632|RGD:1299196
Biological Process	GO:0048709	oligodendrocyte differentiation	enpp2	IMP	ZFIN:ZDB-MRPHLNO-121019-1	Zfish	PMID:22821873
Biological Process	GO:0048709	oligodendrocyte differentiation	enpp2	IMP	ZFIN:ZDB-MRPHLNO-121019-2	Zfish	PMID:22821873
Biological Process	GO:0034638	phosphatidylcholine catabolic process	ENPP2	IDA		Human	PMID:21240271
Biological Process	GO:0034638	phosphatidylcholine catabolic process	Enpp2	IDA		Mouse	MGI:MGI:5050048|PMID:21240269
Biological Process	GO:0034638	phosphatidylcholine catabolic process	Enpp2	IDA		Rat	PMID:21240271|RGD:8553522
Biological Process	GO:0009395	phospholipid catabolic process	ENPP2	IDA		Human	PMID:15280042
Biological Process	GO:0009395	phospholipid catabolic process	ENPP2	IDA		Human	PMID:26371182
Biological Process	GO:0006644	phospholipid metabolic process	Enpp2	IDA		Mouse	PMID:25596343
Biological Process	GO:0008284	positive regulation of cell population proliferation	Enpp2	IDA		Rat	PMID:12119361|RGD:632654
Biological Process	GO:0010634	positive regulation of epithelial cell migration	ENPP2	IGI	UniProtKB:P09327	Human	PMID:18054784
Biological Process	GO:0010634	positive regulation of epithelial cell migration	ENPP2	IMP		Human	PMID:18054784
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	Enpp2	IDA		Rat	PMID:22139091|RGD:9685417
Biological Process	GO:2000394	positive regulation of lamellipodium morphogenesis	ENPP2	IGI	UniProtKB:P09327	Human	PMID:18054784
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	Enpp2	IDA		Rat	PMID:22139091|RGD:9685417
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ENPP2	IDA		Human	PMID:18054784
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	Enpp2	IDA		Rat	PMID:22139091|RGD:9685417
Biological Process	GO:0060215	primitive hemopoiesis	enpp2	IMP	ZFIN:ZDB-MRPHLNO-150827-3	Zfish	PMID:24829209
Biological Process	GO:0045765	regulation of angiogenesis	enpp2	IMP	ZFIN:ZDB-MRPHLNO-120123-5	Zfish	PMID:21971049
Biological Process	GO:0050848	regulation of calcium-mediated signaling	enpp2	IMP	ZFIN:ZDB-MRPHLNO-130116-2	Zfish	PMID:23095890
Biological Process	GO:0030334	regulation of cell migration	ENPP2	IDA		Human	PMID:1733949
Biological Process	GO:1903165	response to polycyclic arene	Enpp2	IEP		Rat	PMID:25490995|RGD:9685420
Biological Process	GO:0030149	sphingolipid catabolic process	ENPP2	IDA		Human	PMID:14500380
Biological Process	GO:0001944	vasculature development	enpp2	IMP	ZFIN:ZDB-MRPHLNO-150827-3	Zfish	PMID:24829209

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern