Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EOMES
  • Mouse genes Eomes
  • Rat genes Eomes
  • Zfish genes eomesa,eomesb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eomes

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Eomes	IDA		Mouse	PMID:21822279
Molecular Function	GO:0031490	chromatin DNA binding	Eomes	IDA		Mouse	PMID:30186101
Molecular Function	GO:0003677	DNA binding	eomesa	IDA		Zfish	PMID:16198294
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	eomesa	IDA		Zfish	PMID:16198294
Molecular Function	GO:0005515	protein binding	eomesa	IPI	UniProtKB:Q9PTQ9	Zfish	PMID:16198294
Molecular Function	GO:0005515	protein binding	eomesa	IPI	UniProtKB:Q9W6U0	Zfish	PMID:16198294
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Eomes	IDA		Mouse	PMID:20176728
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Eomes	IPI	UniProtKB:Q9WUI0	Mouse	MGI:MGI:5448510|PMID:22164283
Molecular Function	GO:0043565	sequence-specific DNA binding	EOMES	IDA		Human	PMID:20713518
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	EOMES	IDA		Human	PMID:28473536
Cellular Component	GO:0000785	chromatin	Eomes	IDA		Mouse	MGI:MGI:5448510|PMID:22164283
Cellular Component	GO:0005737	cytoplasm	eomesa	IDA		Zfish	PMID:14530296
Cellular Component	GO:0005622	intracellular anatomical structure	Eomes	IDA		Mouse	PMID:16892058
Cellular Component	GO:0005634	nucleus	Eomes	IDA		Mouse	PMID:19409883
Cellular Component	GO:0005634	nucleus	Eomes	IDA		Mouse	PMID:15880683
Cellular Component	GO:0005634	nucleus	Eomes	IDA		Mouse	PMID:19796622
Cellular Component	GO:0005634	nucleus	Eomes	IDA		Mouse	PMID:23434913
Cellular Component	GO:0005634	nucleus	Eomes	IDA		Mouse	PMID:25100583
Cellular Component	GO:0005634	nucleus	eomesa	IDA		Zfish	PMID:14530296
Cellular Component	GO:0005634	nucleus	eomesa	IDA		Zfish	PMID:15765511
Biological Process	GO:0048708	astrocyte differentiation	Eomes	IMP		Mouse	PMID:30186101
Biological Process	GO:0001824	blastocyst development	Eomes	IMP	MGI:MGI:3579497	Mouse	PMID:15788452
Biological Process	GO:0007420	brain development	EOMES	IMP		Human	PMID:17353897
Biological Process	GO:0010002	cardioblast differentiation	Eomes	IMP	MGI:MGI:3774028	Mouse	PMID:21822279
Biological Process	GO:0002302	CD8-positive, alpha-beta T cell differentiation involved in immune response	EOMES	IMP		Human	PMID:17566017
Biological Process	GO:0002302	CD8-positive, alpha-beta T cell differentiation involved in immune response	Eomes	IDA		Mouse	MGI:MGI:4399030|PMID:14605368
Biological Process	GO:0030154	cell differentiation	Eomes	IMP	MGI:MGI:3579497	Mouse	PMID:15788452
Biological Process	GO:0030154	cell differentiation	Eomes	IMP	MGI:MGI:2182814	Mouse	PMID:10716450
Biological Process	GO:0060706	cell differentiation involved in embryonic placenta development	Eomes	IMP		Mouse	MGI:MGI:1354065|PMID:10716450
Biological Process	GO:0042074	cell migration involved in gastrulation	eomesa	IMP		Zfish	PMID:15765511
Biological Process	GO:0021987	cerebral cortex development	Eomes	IMP		Mouse	PMID:30186101
Biological Process	GO:0021895	cerebral cortex neuron differentiation	Eomes	IDA		Mouse	MGI:MGI:3831469|PMID:18940588
Biological Process	GO:0021796	cerebral cortex regionalization	Eomes	IMP		Mouse	PMID:30186101
Biological Process	GO:0021796	cerebral cortex regionalization	Eomes	IMP	MGI:MGI:2176173,MGI:MGI:3802572	Mouse	PMID:23431145
Biological Process	GO:0006338	chromatin remodeling	Eomes	IMP		Mouse	PMID:30186101
Biological Process	GO:0048263	determination of dorsal identity	eomesa	IMP		Zfish	PMID:14530296
Biological Process	GO:0080111	DNA demethylation	Eomes	IMP		Mouse	PMID:30186101
Biological Process	GO:0006306	DNA methylation	Eomes	IMP		Mouse	PMID:30186101
Biological Process	GO:0001706	endoderm formation	Eomes	IMP		Mouse	MGI:MGI:3772748|PMID:18171685
Biological Process	GO:0001706	endoderm formation	Eomes	IMP	MGI:MGI:3774028	Mouse	PMID:21822279
Biological Process	GO:0001706	endoderm formation	Eomes	IMP	MGI:MGI:3774028	Mouse	PMID:21245162
Biological Process	GO:0001706	endoderm formation	eomesa	IMP		Zfish	PMID:16198294
Biological Process	GO:0001706	endoderm formation	eomesa	IGI	ZFIN:ZDB-GENE-000208-20	Zfish	PMID:16198294
Biological Process	GO:0001706	endoderm formation	eomesa	IGI	ZFIN:ZDB-MRPHLNO-051112-1,ZFIN:ZDB-MRPHLNO-051112-3,ZFIN:ZDB-MRPHLNO-051112-4,ZFIN:ZDB-MRPHLNO-051205-3	Zfish	PMID:16198294
Biological Process	GO:0001706	endoderm formation	eomesa	IGI	ZFIN:ZDB-GENE-000208-20,ZFIN:ZDB-GENE-980526-340	Zfish	PMID:16198294
Biological Process	GO:0001706	endoderm formation	eomesa	IGI	ZFIN:ZDB-GENE-980526-340	Zfish	PMID:16198294
Biological Process	GO:0001706	endoderm formation	eomesa	IGI	ZFIN:ZDB-GENE-000208-20,ZFIN:ZDB-GENE-980526-340,ZFIN:ZDB-MRPHLNO-050818-2	Zfish	PMID:16198294
Biological Process	GO:0001714	endodermal cell fate specification	Eomes	IMP	MGI:MGI:3774028	Mouse	PMID:21245162
Biological Process	GO:0001714	endodermal cell fate specification	eomesa	IMP	ZFIN:ZDB-GENO-120208-10	Zfish	PMID:22142964
Biological Process	GO:0090504	epiboly	eomesa	IMP	ZFIN:ZDB-GENO-180917-1	Zfish	PMID:29180568
Biological Process	GO:0010467	gene expression	Eomes	IMP	MGI:MGI:3802572	Mouse	PMID:30186101
Biological Process	GO:0055109	invagination involved in gastrulation with mouth forming second	eomesa	IMP	ZFIN:ZDB-GENO-120208-10	Zfish	PMID:22142964
Biological Process	GO:0048382	mesendoderm development	eomesa	IGI	ZFIN:ZDB-GENO-111207-2	Zfish	PMID:21637786
Biological Process	GO:0001707	mesoderm formation	Eomes	IMP	MGI:MGI:2182814	Mouse	PMID:10716450
Biological Process	GO:0060809	mesodermal to mesenchymal transition involved in gastrulation	Eomes	IMP		Mouse	MGI:MGI:3772748|PMID:18171685
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	Eomes	IDA		Mouse	MGI:MGI:5448510|PMID:22164283
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Eomes	IDA		Mouse	MGI:MGI:5448510|PMID:22164283
Biological Process	GO:0022008	neurogenesis	Eomes	IMP	MGI:MGI:3774027	Mouse	PMID:18794345
Biological Process	GO:0030182	neuron differentiation	Eomes	IMP		Mouse	PMID:30186101
Biological Process	GO:0030182	neuron differentiation	Eomes	IMP	MGI:MGI:3774027	Mouse	PMID:18794345
Biological Process	GO:0001764	neuron migration	Eomes	IMP		Mouse	PMID:30186101
Biological Process	GO:0021772	olfactory bulb development	Eomes	IMP	MGI:MGI:3774027	Mouse	PMID:19435790
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	EOMES	IDA		Human	PMID:20713518
Biological Process	GO:0006355	regulation of DNA-templated transcription	eomesa	IMP		Zfish	PMID:15765511
Biological Process	GO:0010468	regulation of gene expression	Eomes	IMP	MGI:MGI:3774028	Mouse	PMID:21245162
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Eomes	IDA		Mouse	PMID:19796622
Biological Process	GO:0035914	skeletal muscle cell differentiation	Eomes	IMP		Mouse	PMID:22147266
Biological Process	GO:0019827	stem cell population maintenance	Eomes	IMP		Mouse	PMID:20176728
Biological Process	GO:0001829	trophectodermal cell differentiation	Eomes	IDA		Mouse	PMID:16325584
Biological Process	GO:0001829	trophectodermal cell differentiation	Eomes	IGI	MGI:MGI:101893	Mouse	PMID:16325584
Biological Process	GO:0032609	type II interferon production	Eomes	IDA		Mouse	PMID:20399120

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern