Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EPCAM
  • Mouse genes Epcam
  • Rat genes Epcam
  • Zfish genes epcam
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Epcam

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0098641	cadherin binding involved in cell-cell adhesion	Epcam	IPI	RGD:68432	Rat	PMID:19276185|RGD:9685062
Molecular Function	GO:0005515	protein binding	EPCAM	IPI	UniProtKB:O95471	Human	PMID:16054130
Molecular Function	GO:0005515	protein binding	EPCAM	IPI	UniProtKB:P12830	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EPCAM	IPI	UniProtKB:P27797	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EPCAM	IPI	UniProtKB:P36957	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EPCAM	IPI	UniProtKB:Q15078	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EPCAM	IPI	UniProtKB:Q8TDX7	Human	PMID:32814053
Molecular Function	GO:0044877	protein-containing complex binding	EPCAM	IDA		Human	PMID:19136966
Cellular Component	GO:0016324	apical plasma membrane	EPCAM	IDA		Human	PMID:18025791
Cellular Component	GO:0016323	basolateral plasma membrane	EPCAM	IDA		Human	PMID:18025791
Cellular Component	GO:0016323	basolateral plasma membrane	epcam	IDA		Zfish	PMID:19609345
Cellular Component	GO:0005923	bicellular tight junction	EPCAM	IDA		Human	PMID:16054130
Cellular Component	GO:0005923	bicellular tight junction	Epcam	IDA		Rat	PMID:16054130|RGD:8554775
Cellular Component	GO:0009986	cell surface	Epcam	IDA		Mouse	PMID:17599412
Cellular Component	GO:0009986	cell surface	Epcam	IDA		Rat	PMID:19276185|RGD:9685062
Cellular Component	GO:0070062	extracellular exosome	EPCAM	HDA		Human	PMID:11487543
Cellular Component	GO:0070062	extracellular exosome	EPCAM	HDA		Human	PMID:19056867
Cellular Component	GO:0016328	lateral plasma membrane	EPCAM	IDA		Human	PMID:16054130
Cellular Component	GO:0016328	lateral plasma membrane	Epcam	IDA		Rat	PMID:16054130|RGD:8554775
Cellular Component	GO:0016020	membrane	Epcam	IDA		Rat	PMID:10327052|RGD:634200
Cellular Component	GO:0048471	perinuclear region of cytoplasm	epcam	IDA		Zfish	PMID:16552761
Cellular Component	GO:0005886	plasma membrane	EPCAM	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	EPCAM	IDA		Human	PMID:15195135
Cellular Component	GO:0005886	plasma membrane	EPCAM	IDA		Human	PMID:19785009
Cellular Component	GO:0005886	plasma membrane	Epcam	IDA		Rat	PMID:10327052|RGD:634200
Cellular Component	GO:0005886	plasma membrane	epcam	IDA		Zfish	PMID:23484855
Cellular Component	GO:0005886	plasma membrane	epcam	IDA		Zfish	PMID:16552761
Biological Process	GO:0098609	cell-cell adhesion	epcam	IGI	ZFIN:ZDB-MRPHLNO-050421-1	Zfish	PMID:19609345
Biological Process	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	Epcam	IDA		Rat	PMID:19276185|RGD:9685062
Biological Process	GO:0044782	cilium organization	epcam	IMP	ZFIN:ZDB-GENO-221020-4	Zfish	PMID:33693707
Biological Process	GO:0055113	epiboly involved in gastrulation with mouth forming second	epcam	IGI	ZFIN:ZDB-MRPHLNO-050421-1	Zfish	PMID:19609345
Biological Process	GO:0001889	liver development	epcam	IGI	ZFIN:ZDB-MRPHLNO-100308-1	Zfish	PMID:23484855
Biological Process	GO:0001889	liver development	epcam	IGI	ZFIN:ZDB-MRPHLNO-060824-3	Zfish	PMID:23484855
Biological Process	GO:0001889	liver development	epcam	IMP	ZFIN:ZDB-GENO-140424-7	Zfish	PMID:23484855
Biological Process	GO:0001889	liver development	epcam	IGI	ZFIN:ZDB-GENO-111223-13,ZFIN:ZDB-MRPHLNO-130430-1	Zfish	PMID:23484855
Biological Process	GO:0002009	morphogenesis of an epithelium	epcam	IMP	ZFIN:ZDB-GENO-110729-1	Zfish	PMID:19609345
Biological Process	GO:0043066	negative regulation of apoptotic process	Epcam	IDA		Rat	PMID:19276185|RGD:9685062
Biological Process	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin	EPCAM	IDA		Human	PMID:9382878
Biological Process	GO:0032475	otolith formation	epcam	IMP	ZFIN:ZDB-GENO-221020-4	Zfish	PMID:33693707
Biological Process	GO:2000147	positive regulation of cell motility	Epcam	IDA		Rat	PMID:19276185|RGD:9685062
Biological Process	GO:0008284	positive regulation of cell population proliferation	EPCAM	IDA		Human	PMID:15195135
Biological Process	GO:2000648	positive regulation of stem cell proliferation	EPCAM	IMP		Human	PMID:19785009
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	EPCAM	IDA		Human	PMID:15195135
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	EPCAM	IDA		Human	PMID:15922867
Biological Process	GO:0048920	posterior lateral line neuromast primordium migration	epcam	IGI	ZFIN:ZDB-MRPHLNO-070507-5,ZFIN:ZDB-MRPHLNO-080310-1	Zfish	PMID:29945870
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	EPCAM	IMP		Human	PMID:19136966
Biological Process	GO:0048863	stem cell differentiation	EPCAM	IMP		Human	PMID:19785009
Biological Process	GO:0001657	ureteric bud development	Epcam	IEP		Mouse	MGI:MGI:3655805|PMID:16545622

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern