Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EPGN
  • Mouse genes Epgn
  • Rat genes Epgn
  • Zfish genes epgn
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Epgn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005154	epidermal growth factor receptor binding	EPGN	IDA		Human	PMID:15611079
Molecular Function	GO:0005154	epidermal growth factor receptor binding	Epgn	IDA		Mouse	MGI:MGI:1934957|PMID:11278323
Molecular Function	GO:0008083	growth factor activity	EPGN	IDA		Human	PMID:15611079
Molecular Function	GO:0008083	growth factor activity	Epgn	IDA		Mouse	PMID:11278323
Molecular Function	GO:0005515	protein binding	EPGN	IPI	UniProtKB:P00533	Human	PMID:28988771
Molecular Function	GO:0048018	receptor ligand activity	Epgn	IDA		Mouse	PMID:11278323
Molecular Function	GO:0048018	receptor ligand activity	Epgn	IGI	MGI:MGI:95294	Mouse	PMID:24891618
Molecular Function	GO:0048018	receptor ligand activity	Epgn	IGI	MGI:MGI:95294	Mouse	PMID:23899604
Cellular Component	GO:0005615	extracellular space	Epgn	IDA		Mouse	PMID:11278323
Cellular Component	GO:0005886	plasma membrane	EPGN	IDA		Human	PMID:15611079
Biological Process	GO:0001525	angiogenesis	EPGN	IDA		Human	PMID:15611079
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Epgn	IGI	MGI:MGI:95294	Mouse	PMID:23899604
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Epgn	IGI	MGI:MGI:95294	Mouse	PMID:24891618
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	Epgn	IDA		Mouse	PMID:11278323
Biological Process	GO:0000165	MAPK cascade	Epgn	IDA		Mouse	PMID:11278323
Biological Process	GO:0008284	positive regulation of cell population proliferation	EPGN	IDA		Human	PMID:15611079
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	EPGN	IDA		Human	PMID:15611079
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	Epgn	IDA		Mouse	MGI:MGI:1934957|PMID:11278323
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Epgn	IDA		Mouse	MGI:MGI:1934957|PMID:11278323
Biological Process	GO:0043406	positive regulation of MAP kinase activity	EPGN	IDA		Human	PMID:15611079
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Epgn	IDA		Mouse	MGI:MGI:1934957|PMID:11278323
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	EPGN	IDA		Human	PMID:15611079
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	Epgn	IDA		Mouse	MGI:MGI:1934957|PMID:11278323

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern