Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Epha2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes EPHA2
- Mouse genes Epha2
- Rat genes Epha2
- Zfish genes epha2a,epha2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Epha2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	EPHA2	HDA		Human	PMID:25468996
Molecular Function	GO:0019838	growth factor binding	EPHA2	IPI	UniProtKB:P52793	Human	PMID:22568954
Molecular Function	GO:0019838	growth factor binding	EPHA2	IPI	UniProtKB:P52797	Human	PMID:22568954
Molecular Function	GO:0019838	growth factor binding	EPHA2	IPI	UniProtKB:P52803	Human	PMID:22568954
Molecular Function	GO:0140677	molecular function activator activity	EPHA2	EXP		Human	PMID:12467573
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:Q05397	Human	PMID:10655584
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:Q06124	Human	PMID:10655584
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:P20827	Human	PMID:15777695
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:P35222	Human	PMID:18948590
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:P20827	Human	PMID:19525919
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:P20827	Human	PMID:19573808
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:P52803	Human	PMID:20228801
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:P20827	Human	PMID:20505120
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:P52803	Human	PMID:20505120
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:Q5VV41	Human	PMID:20679435
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:Q8N1I0	Human	PMID:20679435
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:Q96JJ3	Human	PMID:20679435
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:Q15375	Human	PMID:22036564
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:O15357-1	Human	PMID:22244754
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:P20827	Human	PMID:22244754
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:P16333	Human	PMID:23358419
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:P55196	Human	PMID:27815408
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:Q06124	Human	PMID:28065597
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:P29320	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:P29376	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:P30530	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:P54756	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:Q06124	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:Q15375	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	EPHA2	IPI	UniProtKB:Q9UF33	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	Epha2	IPI	UniProtKB:Q03137	Mouse	MGI:MGI:5508623\|PMID:16977320
Molecular Function	GO:0005515	protein binding	Epha2	IPI	UniProtKB:Q60992\|UniProtKB:Q9R0C8	Mouse	MGI:MGI:3640033\|PMID:16782872
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	EPHA2	IDA		Human	PMID:10655584
Cellular Component	GO:0009986	cell surface	EPHA2	HDA		Human	PMID:19581412
Cellular Component	GO:0009986	cell surface	EPHA2	IDA		Human	PMID:25063885
Cellular Component	GO:0009986	cell surface	Epha2	IDA		Mouse	PMID:27733379
Cellular Component	GO:0005925	focal adhesion	EPHA2	IDA		Human	PMID:10655584
Cellular Component	GO:0005925	focal adhesion	EPHA2	HDA		Human	PMID:21423176
Cellular Component	GO:0030027	lamellipodium	EPHA2	IDA		Human	PMID:26158630
Cellular Component	GO:0031256	leading edge membrane	EPHA2	IDA		Human	PMID:19573808
Cellular Component	GO:0031256	leading edge membrane	EPHA2	IDA		Human	PMID:20679435
Cellular Component	GO:0005886	plasma membrane	EPHA2	IDA		Human	PMID:10655584
Cellular Component	GO:0005886	plasma membrane	EPHA2	IDA		Human	PMID:18794797
Cellular Component	GO:0005886	plasma membrane	EPHA2	IDA		Human	PMID:20861311
Cellular Component	GO:0005886	plasma membrane	EPHA2	IDA		Human	PMID:16862074
Cellular Component	GO:0070160	tight junction	EPHA2	IDA		Human	PMID:27815408
Biological Process	GO:0090630	activation of GTPase activity	EPHA2	IMP		Human	PMID:20679435
Biological Process	GO:0048320	axial mesoderm formation	Epha2	IMP	MGI:MGI:2448472	Mouse	PMID:11287184
Biological Process	GO:0001568	blood vessel development	Epha2	IMP	MGI:MGI:2448472	Mouse	PMID:11287184
Biological Process	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis	Epha2	IMP	MGI:MGI:3040415	Mouse	PMID:19443703
Biological Process	GO:0048514	blood vessel morphogenesis	Epha2	IMP	MGI:MGI:3040415	Mouse	PMID:19443703
Biological Process	GO:0046849	bone remodeling	Epha2	IMP		Mouse	MGI:MGI:5284751\|PMID:19299512
Biological Process	GO:0060444	branching involved in mammary gland duct morphogenesis	Epha2	IMP		Mouse	MGI:MGI:5284750\|PMID:19321667
Biological Process	GO:0046058	cAMP metabolic process	EPHA2	IMP		Human	PMID:27385333
Biological Process	GO:0060326	cell chemotaxis	EPHA2	IMP		Human	PMID:19573808
Biological Process	GO:0060326	cell chemotaxis	EPHA2	IMP		Human	PMID:20679435
Biological Process	GO:0016477	cell migration	EPHA2	IMP		Human	PMID:23358419
Biological Process	GO:0048870	cell motility	EPHA2	IMP		Human	PMID:26158630
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Epha2	IMP	MGI:MGI:3040415	Mouse	PMID:19443703
Biological Process	GO:0048013	ephrin receptor signaling pathway	EPHA2	IDA		Human	PMID:10655584
Biological Process	GO:0048013	ephrin receptor signaling pathway	EPHA2	IDA		Human	PMID:20861311
Biological Process	GO:0048013	ephrin receptor signaling pathway	Epha2	IMP		Mouse	MGI:MGI:3831440\|PMID:18948590
Biological Process	GO:0048013	ephrin receptor signaling pathway	Epha2	IDA		Mouse	PMID:14988728
Biological Process	GO:0006954	inflammatory response	Epha2	IMP	MGI:MGI:3040415	Mouse	PMID:19443703
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	EPHA2	IDA		Human	PMID:18339848
Biological Process	GO:0030216	keratinocyte differentiation	EPHA2	IMP		Human	PMID:20861311
Biological Process	GO:0070309	lens fiber cell morphogenesis	Epha2	IDA		Mouse	MGI:MGI:3831440\|PMID:18948590
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	Epha2	IMP		Mouse	MGI:MGI:5284750\|PMID:19321667
Biological Process	GO:0016525	negative regulation of angiogenesis	Epha2	IMP	MGI:MGI:3040415	Mouse	PMID:19443703
Biological Process	GO:0032682	negative regulation of chemokine production	Epha2	IMP	MGI:MGI:3040415	Mouse	PMID:19443703
Biological Process	GO:0001818	negative regulation of cytokine production	Epha2	IMP	MGI:MGI:3040415	Mouse	PMID:19443703
Biological Process	GO:1901491	negative regulation of lymphangiogenesis	Epha2	IMP	MGI:MGI:3040415	Mouse	PMID:19443703
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	EPHA2	IDA		Human	PMID:19573808
Biological Process	GO:0021915	neural tube development	Epha2	IMP	MGI:MGI:2448472	Mouse	PMID:11287184
Biological Process	GO:0030182	neuron differentiation	Epha2	IDA		Mouse	PMID:15145949
Biological Process	GO:0030182	neuron differentiation	Epha2	IMP		Mouse	PMID:15145949
Biological Process	GO:0060035	notochord cell development	Epha2	IMP	MGI:MGI:2448472	Mouse	PMID:11287184
Biological Process	GO:0014028	notochord formation	Epha2	IGI	MGI:MGI:103236	Mouse	PMID:11287184
Biological Process	GO:0014028	notochord formation	Epha2	IMP	MGI:MGI:2448472	Mouse	PMID:11287184
Biological Process	GO:0048570	notochord morphogenesis	Epha2	IMP	MGI:MGI:2448472	Mouse	PMID:11287184
Biological Process	GO:0001649	osteoblast differentiation	Epha2	IMP		Mouse	MGI:MGI:5284751\|PMID:19299512
Biological Process	GO:0030316	osteoclast differentiation	Epha2	IDA		Mouse	MGI:MGI:5284751\|PMID:19299512
Biological Process	GO:1904238	pericyte cell differentiation	Epha2	IMP	MGI:MGI:3040415	Mouse	PMID:19443703
Biological Process	GO:1903348	positive regulation of bicellular tight junction assembly	EPHA2	IMP		Human	PMID:27815408
Biological Process	GO:0030335	positive regulation of cell migration	EPHA2	IDA		Human	PMID:24002999
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	EPHA2	IMP		Human	PMID:20679435
Biological Process	GO:0036342	post-anal tail morphogenesis	Epha2	IMP	MGI:MGI:2448472	Mouse	PMID:11287184
Biological Process	GO:0043491	protein kinase B signaling	EPHA2	IDA		Human	PMID:19573808
Biological Process	GO:0072659	protein localization to plasma membrane	EPHA2	IMP		Human	PMID:27815408
Biological Process	GO:0045765	regulation of angiogenesis	Epha2	IDA		Mouse	MGI:MGI:3640033\|PMID:16782872
Biological Process	GO:0043535	regulation of blood vessel endothelial cell migration	Epha2	IDA		Mouse	MGI:MGI:3640033\|PMID:16782872
Biological Process	GO:0033628	regulation of cell adhesion mediated by integrin	EPHA2	IDA		Human	PMID:10655584
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	EPHA2	IMP		Human	PMID:20861311
Biological Process	GO:0010591	regulation of lamellipodium assembly	EPHA2	IMP		Human	PMID:19573808
Biological Process	GO:0070848	response to growth factor	EPHA2	IMP		Human	PMID:19573808
Biological Process	GO:0001501	skeletal system development	Epha2	IMP	MGI:MGI:2448472	Mouse	PMID:11287184
Biological Process	GO:0001570	vasculogenesis	Epha2	IMP	MGI:MGI:2448472	Mouse	PMID:11287184

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.