Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EPHA3
  • Mouse genes Epha3
  • Rat genes Epha3
  • Zfish genes epha3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Epha3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005003	ephrin receptor activity	EPHA3	IDA		Human	PMID:11519828
Molecular Function	GO:0005003	ephrin receptor activity	Epha3	IDA		Mouse	PMID:15145949
Molecular Function	GO:0005004	GPI-linked ephrin receptor activity	EPHA3	IDA		Human	PMID:11870224
Molecular Function	GO:0019838	growth factor binding	Epha3	IPI	UniProtKB:P52801	Mouse	MGI:MGI:6478053|PMID:22568954
Molecular Function	GO:0019838	growth factor binding	Epha3	IPI	UniProtKB:P52797	Mouse	MGI:MGI:6478053|PMID:22568954
Molecular Function	GO:0005515	protein binding	EPHA3	IPI	UniProtKB:P20827	Human	PMID:11519828
Molecular Function	GO:0005515	protein binding	EPHA3	IPI	UniProtKB:P52797	Human	PMID:11519828
Molecular Function	GO:0005515	protein binding	EPHA3	IPI	UniProtKB:P52798	Human	PMID:11519828
Molecular Function	GO:0005515	protein binding	EPHA3	IPI	UniProtKB:P52803	Human	PMID:11519828
Molecular Function	GO:0005515	protein binding	EPHA3	IPI	UniProtKB:Q15768	Human	PMID:11519828
Molecular Function	GO:0005515	protein binding	EPHA3	IPI	UniProtKB:P46108	Human	PMID:11870224
Molecular Function	GO:0005515	protein binding	EPHA3	IPI	UniProtKB:P52803	Human	PMID:11870224
Molecular Function	GO:0005515	protein binding	EPHA3	IPI	UniProtKB:Q64010	Human	PMID:11870224
Molecular Function	GO:0005515	protein binding	EPHA3	IPI	UniProtKB:Q8WXA3	Human	PMID:11877430
Molecular Function	GO:0005515	protein binding	EPHA3	IPI	UniProtKB:Q96T51	Human	PMID:11877430
Molecular Function	GO:0005515	protein binding	EPHA3	IPI	UniProtKB:P18031	Human	PMID:21135139
Molecular Function	GO:0005515	protein binding	EPHA3	IPI	UniProtKB:Q15375	Human	PMID:22036564
Molecular Function	GO:0005515	protein binding	EPHA3	IPI	UniProtKB:P29317	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	EPHA3	IPI	UniProtKB:Q15375	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	Epha3	IPI	PR:Q99M51	Mouse	PMID:19505147
Cellular Component	GO:0015629	actin cytoskeleton	EPHA3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	EPHA3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005769	early endosome	EPHA3	IDA		Human	PMID:21135139
Cellular Component	GO:0098982	GABA-ergic synapse	Epha3	IDA		Mouse	PMID:22275477
Cellular Component	GO:0098982	GABA-ergic synapse	Epha3	IMP		Mouse	PMID:22275477
Cellular Component	GO:0098982	GABA-ergic synapse	Epha3	IPI		Mouse	PMID:22275477
Cellular Component	GO:0031965	nuclear membrane	EPHA3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	EPHA3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	EPHA3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	EPHA3	IDA		Human	PMID:11870224
Cellular Component	GO:0005886	plasma membrane	EPHA3	IDA		Human	PMID:21135139
Cellular Component	GO:0098793	presynapse	Epha3	IDA		Mouse	PMID:22275477
Biological Process	GO:0016477	cell migration	Epha3	IMP		Mouse	MGI:MGI:3703403|PMID:17046737
Biological Process	GO:0071372	cellular response to follicle-stimulating hormone stimulus	Epha3	IDA		Mouse	PMID:23242526
Biological Process	GO:0071300	cellular response to retinoic acid	EPHA3	IMP		Human	PMID:17910947
Biological Process	GO:0003197	endocardial cushion development	Epha3	IMP		Mouse	MGI:MGI:3703403|PMID:17046737
Biological Process	GO:0048013	ephrin receptor signaling pathway	EPHA3	IDA		Human	PMID:11870224
Biological Process	GO:0048013	ephrin receptor signaling pathway	Epha3	IDA		Mouse	MGI:MGI:4936768|PMID:21135139
Biological Process	GO:0097156	fasciculation of motor neuron axon	Epha3	IMP		Mouse	MGI:MGI:3783924|PMID:18403711
Biological Process	GO:0097155	fasciculation of sensory neuron axon	Epha3	IMP		Mouse	MGI:MGI:5140627|PMID:21791286
Biological Process	GO:0001660	fever generation	Epha3	IEP		Rat	PMID:15671251|RGD:1581943
Biological Process	GO:0007509	mesoderm migration involved in gastrulation	epha3	IMP		Zfish	PMID:10381569
Biological Process	GO:0045806	negative regulation of endocytosis	EPHA3	IDA		Human	PMID:11877430
Biological Process	GO:0010977	negative regulation of neuron projection development	Epha3	IDA		Mouse	PMID:19505147
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	EPHA3	IDA		Human	PMID:11877430
Biological Process	GO:0010976	positive regulation of neuron projection development	EPHA3	IMP		Human	PMID:17910947
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	EPHA3	IDA		Human	PMID:11877430
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	EPHA3	IDA		Human	PMID:11870224
Biological Process	GO:0030334	regulation of cell migration	Epha3	IGI	MGI:MGI:109601	Mouse	PMID:19505147
Biological Process	GO:0010717	regulation of epithelial to mesenchymal transition	Epha3	IMP		Mouse	MGI:MGI:3703403|PMID:17046737
Biological Process	GO:0051893	regulation of focal adhesion assembly	EPHA3	IDA		Human	PMID:11870224
Biological Process	GO:0043087	regulation of GTPase activity	EPHA3	IDA		Human	PMID:11870224
Biological Process	GO:0070507	regulation of microtubule cytoskeleton organization	EPHA3	IDA		Human	PMID:11870224
Biological Process	GO:0034097	response to cytokine	Epha3	IEP		Rat	PMID:9458884|RGD:68243
Biological Process	GO:0032496	response to lipopolysaccharide	Epha3	IEP		Rat	PMID:15671251|RGD:1581943
Biological Process	GO:0001756	somitogenesis	epha3	IMP		Zfish	PMID:10381569
Biological Process	GO:0099560	synaptic membrane adhesion	Epha3	IDA		Mouse	PMID:22275477
Biological Process	GO:0099560	synaptic membrane adhesion	Epha3	IMP		Mouse	PMID:22275477
Biological Process	GO:0099560	synaptic membrane adhesion	Epha3	IPI		Mouse	PMID:22275477

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern