Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EPHB2
  • Mouse genes Ephb2
  • Rat genes Ephb2
  • Zfish genes ephb2a,ephb2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ephb2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001540	amyloid-beta binding	Ephb2	IPI	UniProtKB:P05067:PRO_0000000092	Mouse	MGI:MGI:4867584|PMID:21113149
Molecular Function	GO:0008046	axon guidance receptor activity	Ephb2	IDA		Mouse	PMID:11532925
Molecular Function	GO:0005003	ephrin receptor activity	Ephb2	IDA		Mouse	PMID:11780069
Molecular Function	GO:0042802	identical protein binding	Ephb2	IPI	UniProtKB:P54763	Mouse	MGI:MGI:5508623|PMID:16977320
Molecular Function	GO:0005515	protein binding	EPHB2	IPI	UniProtKB:P49790	Human	PMID:17255949
Molecular Function	GO:0005515	protein binding	EPHB2	IPI	UniProtKB:Q96A44	Human	PMID:28931592
Molecular Function	GO:0005515	protein binding	EPHB2	IPI	UniProtKB:Q96BD6	Human	PMID:28931592
Molecular Function	GO:0005515	protein binding	EPHB2	IDA		Human	PMID:33280498
Molecular Function	GO:0005515	protein binding	EPHB2	IPI	UniProtKB:P07333	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	EPHB2	IPI	UniProtKB:P54764	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	EPHB2	IPI	UniProtKB:Q15375	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	Ephb2	IPI	UniProtKB:P05480|UniProtKB:P34152	Mouse	MGI:MGI:3694172|PMID:16298995
Molecular Function	GO:0005515	protein binding	Ephb2	IPI	UniProtKB:Q13009	Mouse	MGI:MGI:6092669|PMID:17440041
Molecular Function	GO:0005515	protein binding	Ephb2	IPI	UniProtKB:Q925T6	Mouse	MGI:MGI:1327089|PMID:9883737
Molecular Function	GO:0005515	protein binding	Ephb2	IPI	UniProtKB:Q96A44	Mouse	MGI:MGI:6243331|PMID:28931592
Molecular Function	GO:0005515	protein binding	Ephb2	IPI	UniProtKB:Q03137	Mouse	MGI:MGI:5508623|PMID:16977320
Molecular Function	GO:0005515	protein binding	Ephb2	IPI	UniProtKB:P12023:PRO_0000000118	Mouse	MGI:MGI:4867584|PMID:21113149
Molecular Function	GO:0005515	protein binding	Ephb2	IPI	UniProtKB:Q02013	Mouse	MGI:MGI:1859095|PMID:10839360
Molecular Function	GO:0005515	protein binding	Ephb2	IPI	UniProtKB:Q5FWH6-2	Mouse	MGI:MGI:4881358|PMID:21029865
Molecular Function	GO:0005515	protein binding	Ephb2	IPI	UniProtKB:P52796|UniProtKB:Q62083|UniProtKB:Q925T6	Mouse	MGI:MGI:1327089|PMID:9883737
Molecular Function	GO:0005515	protein binding	Ephb2	IPI	PR:P54761	Mouse	PMID:12971893
Molecular Function	GO:0005515	protein binding	Ephb2	IPI	PR:P52800	Mouse	PMID:11780069
Molecular Function	GO:0005515	protein binding	Ephb2	IPI	PR:P35438	Mouse	PMID:11754835
Molecular Function	GO:0004713	protein tyrosine kinase activity	Ephb2	IMP		Mouse	MGI:MGI:4867584|PMID:21113149
Molecular Function	GO:0004713	protein tyrosine kinase activity	Ephb2	IDA		Mouse	MGI:MGI:1327089|PMID:9883737
Molecular Function	GO:0044877	protein-containing complex binding	Ephb2	IPI	ComplexPortal:CPX-1070|ComplexPortal:CPX-1134	Mouse	MGI:MGI:4867584|PMID:21113149
Molecular Function	GO:0044877	protein-containing complex binding	Ephb2	IPI	ComplexPortal:CPX-1062|ComplexPortal:CPX-1120	Rat	PMID:21113149|RGD:12859080
Molecular Function	GO:0044877	protein-containing complex binding	Ephb2	IPI	ComplexPortal:CPX-1070|ComplexPortal:CPX-1134	Rat	PMID:21113149|RGD:12859080
Molecular Function	GO:0038023	signaling receptor activity	Ephb2	IDA		Mouse	PMID:11780069
Molecular Function	GO:0005102	signaling receptor binding	Ephb2	IPI	PR:P35438	Mouse	PMID:11754835
Molecular Function	GO:0005005	transmembrane-ephrin receptor activity	Ephb2	IDA		Mouse	MGI:MGI:4881358|PMID:21029865
Cellular Component	GO:0030424	axon	Ephb2	IDA		Mouse	MGI:MGI:81675|PMID:8689685
Cellular Component	GO:0009986	cell surface	Ephb2	IDA		Rat	PMID:15965473|RGD:127285651
Cellular Component	GO:0030425	dendrite	Ephb2	IDA		Mouse	MGI:MGI:2683349|PMID:14691139
Cellular Component	GO:0030425	dendrite	Ephb2	IDA		Rat	PMID:15965473|RGD:127285651
Cellular Component	GO:0043197	dendritic spine	Ephb2	IDA		Rat	PMID:16394100|RGD:2302413
Cellular Component	GO:0098978	glutamatergic synapse	Ephb2	IDA		Mouse	PMID:18410519
Cellular Component	GO:0098978	glutamatergic synapse	Ephb2	IEP		Mouse	PMID:18410519
Cellular Component	GO:0098978	glutamatergic synapse	Ephb2	IMP		Mouse	PMID:17122040
Cellular Component	GO:0098978	glutamatergic synapse	Ephb2	IDA		Mouse	PMID:17122040
Cellular Component	GO:0098978	glutamatergic synapse	Ephb2	EXP		Mouse	PMID:17122040
Cellular Component	GO:0098978	glutamatergic synapse	Ephb2	IDA		Rat	PMID:11136979|RGD:13702452
Cellular Component	GO:0098978	glutamatergic synapse	Ephb2	IMP		Rat	PMID:11136979|RGD:13702452
Cellular Component	GO:0005794	Golgi apparatus	Ephb2	IDA		Rat	PMID:15965473|RGD:127285651
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Ephb2	IDA		Mouse	PMID:30185604
Cellular Component	GO:0098686	hippocampal mossy fiber to CA3 synapse	Ephb2	IPI		Mouse	PMID:30185604
Cellular Component	GO:0043025	neuronal cell body	Ephb2	IDA		Mouse	PMID:12971893
Cellular Component	GO:0043025	neuronal cell body	Ephb2	IDA		Rat	PMID:15965473|RGD:127285651
Cellular Component	GO:0005654	nucleoplasm	EPHB2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	EPHB2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Ephb2	IDA		Mouse	MGI:MGI:81675|PMID:8689685
Cellular Component	GO:0098794	postsynapse	Ephb2	IDA		Rat	PMID:19160501|RGD:152998909
Cellular Component	GO:0045211	postsynaptic membrane	Ephb2	IDA		Mouse	PMID:18410519
Cellular Component	GO:0045211	postsynaptic membrane	Ephb2	IEP		Mouse	PMID:18410519
Cellular Component	GO:0045211	postsynaptic membrane	Ephb2	IDA		Mouse	PMID:30185604
Cellular Component	GO:0045211	postsynaptic membrane	Ephb2	IPI		Mouse	PMID:30185604
Cellular Component	GO:0042734	presynaptic membrane	Ephb2	IDA		Mouse	PMID:18410519
Cellular Component	GO:0042734	presynaptic membrane	Ephb2	IEP		Mouse	PMID:18410519
Biological Process	GO:0001525	angiogenesis	Ephb2	IMP		Mouse	MGI:MGI:1331270|PMID:9990854
Biological Process	GO:0009887	animal organ morphogenesis	Ephb2	IMP	MGI:MGI:2149670	Mouse	PMID:15223334
Biological Process	GO:0007411	axon guidance	Ephb2	IMP		Mouse	MGI:MGI:1859095|PMID:10839360
Biological Process	GO:0007411	axon guidance	Ephb2	IMP		Mouse	MGI:MGI:84499|PMID:8947026
Biological Process	GO:0007411	axon guidance	Ephb2	IDA		Mouse	PMID:11532925
Biological Process	GO:0007413	axonal fasciculation	Ephb2	IMP		Mouse	MGI:MGI:84499|PMID:8947026
Biological Process	GO:0007409	axonogenesis	Ephb2	IDA		Mouse	PMID:12971893
Biological Process	GO:0042113	B cell activation	EPHB2	IMP		Human	PMID:24803541
Biological Process	GO:0001568	blood vessel development	ephb2a	IGI	ZFIN:ZDB-GENE-990415-62	Zfish	PMID:24837431
Biological Process	GO:0001568	blood vessel development	ephb2a	IGI	ZFIN:ZDB-GENE-030131-4694	Zfish	PMID:24837431
Biological Process	GO:0048593	camera-type eye morphogenesis	Ephb2	IMP	MGI:MGI:2149765	Mouse	PMID:12971893
Biological Process	GO:0000902	cell morphogenesis	Ephb2	IGI	MGI:MGI:107708	Mouse	PMID:17686994
Biological Process	GO:1904646	cellular response to amyloid-beta	Ephb2	IEP		Rat	PMID:23831214|RGD:127285646
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Ephb2	IEP		Rat	PMID:33794069|RGD:127285659
Biological Process	GO:0021952	central nervous system projection neuron axonogenesis	Ephb2	IMP		Mouse	PMID:12971893
Biological Process	GO:0071679	commissural neuron axon guidance	Ephb2	IMP		Mouse	MGI:MGI:81675|PMID:8689685
Biological Process	GO:0060026	convergent extension	ephb2a	IGI	ZFIN:ZDB-MRPHLNO-070702-1,ZFIN:ZDB-MRPHLNO-070713-1	Zfish	PMID:17412835
Biological Process	GO:0022038	corpus callosum development	Ephb2	IMP		Mouse	MGI:MGI:84499|PMID:8947026
Biological Process	GO:0060996	dendritic spine development	Ephb2	IMP		Mouse	MGI:MGI:2683349|PMID:14691139
Biological Process	GO:0060997	dendritic spine morphogenesis	Ephb2	IMP		Mouse	MGI:MGI:2683349|PMID:14691139
Biological Process	GO:0060997	dendritic spine morphogenesis	Ephb2	IDA		Mouse	PMID:17310244
Biological Process	GO:0048013	ephrin receptor signaling pathway	Ephb2	IDA		Mouse	MGI:MGI:4881358|PMID:21029865
Biological Process	GO:0048013	ephrin receptor signaling pathway	Ephb2	IDA		Mouse	PMID:17310244
Biological Process	GO:0048013	ephrin receptor signaling pathway	Ephb2	IDA		Mouse	PMID:17686994
Biological Process	GO:0048013	ephrin receptor signaling pathway	ephb2a	IGI	ZFIN:ZDB-GENE-030131-4694	Zfish	PMID:24837431
Biological Process	GO:0021934	hindbrain tangential cell migration	Ephb2	IMP		Rat	PMID:28276447|RGD:127285619
Biological Process	GO:0042472	inner ear morphogenesis	Ephb2	IMP		Mouse	MGI:MGI:1859095|PMID:10839360
Biological Process	GO:0007612	learning	Ephb2	IMP	MGI:MGI:2149765	Mouse	PMID:11754835
Biological Process	GO:0007611	learning or memory	Ephb2	IGI	UniProtKB:P05067	Mouse	MGI:MGI:4867584|PMID:21113149
Biological Process	GO:0050771	negative regulation of axonogenesis	Ephb2	IDA		Mouse	PMID:12971893
Biological Process	GO:0007162	negative regulation of cell adhesion	EPHB2	IMP		Human	PMID:23835497
Biological Process	GO:1900016	negative regulation of cytokine production involved in inflammatory response	Ephb2	IDA		Rat	PMID:33722292|RGD:127285641
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Ephb2	IDA		Mouse	MGI:MGI:5905277|PMID:11585923
Biological Process	GO:1904782	negative regulation of NMDA glutamate receptor activity	Ephb2	IMP		Mouse	MGI:MGI:4867584|PMID:21113149
Biological Process	GO:0006469	negative regulation of protein kinase activity	Ephb2	IDA		Mouse	MGI:MGI:5905277|PMID:11585923
Biological Process	GO:0001933	negative regulation of protein phosphorylation	Ephb2	IDA		Mouse	MGI:MGI:5905277|PMID:11585923
Biological Process	GO:0046580	negative regulation of Ras protein signal transduction	Ephb2	IDA		Mouse	MGI:MGI:5905277|PMID:11585923
Biological Process	GO:0106028	neuron projection retraction	Ephb2	IDA		Mouse	MGI:MGI:5905277|PMID:11585923
Biological Process	GO:0021631	optic nerve morphogenesis	Ephb2	IMP	MGI:MGI:2149765	Mouse	PMID:12971893
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Ephb2	IDA		Mouse	MGI:MGI:4881358|PMID:21029865
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Ephb2	IMP		Mouse	MGI:MGI:4867584|PMID:21113149
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Ephb2	IDA		Mouse	PMID:17686994
Biological Process	GO:0016310	phosphorylation	Ephb2	IDA		Mouse	MGI:MGI:1327089|PMID:9883737
Biological Process	GO:0030890	positive regulation of B cell proliferation	EPHB2	IMP		Human	PMID:24803541
Biological Process	GO:0030335	positive regulation of cell migration	EPHB2	IGI	RNAcentral:URS000029D9F1_9606	Human	PMID:23204229
Biological Process	GO:0030335	positive regulation of cell migration	EPHB2	IGI	RNAcentral:URS000024A59E_9606	Human	PMID:23835497
Biological Process	GO:0061003	positive regulation of dendritic spine morphogenesis	Ephb2	IMP		Rat	PMID:21364901|RGD:127285794
Biological Process	GO:0010628	positive regulation of gene expression	Ephb2	IMP		Rat	PMID:21113149|RGD:12859080
Biological Process	GO:0002639	positive regulation of immunoglobulin production	EPHB2	IMP		Human	PMID:24803541
Biological Process	GO:0048170	positive regulation of long-term neuronal synaptic plasticity	Ephb2	IMP	MGI:MGI:2149765	Mouse	PMID:11754836
Biological Process	GO:1900273	positive regulation of long-term synaptic potentiation	Ephb2	IMP		Mouse	MGI:MGI:4867584|PMID:21113149
Biological Process	GO:1904783	positive regulation of NMDA glutamate receptor activity	Ephb2	IMP		Mouse	MGI:MGI:4867584|PMID:21113149
Biological Process	GO:2000010	positive regulation of protein localization to cell surface	Ephb2	IDA		Rat	PMID:19160501|RGD:152998909
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	Ephb2	IMP		Rat	PMID:21113149|RGD:12859080
Biological Process	GO:0051965	positive regulation of synapse assembly	Ephb2	IDA		Mouse	MGI:MGI:4881358|PMID:21029865
Biological Process	GO:0051965	positive regulation of synapse assembly	Ephb2	IMP		Mouse	MGI:MGI:2683349|PMID:14691139
Biological Process	GO:0051965	positive regulation of synapse assembly	Ephb2	IMP		Rat	PMID:21364901|RGD:127285794
Biological Process	GO:0031915	positive regulation of synaptic plasticity	Ephb2	IGI	UniProtKB:P05067	Mouse	MGI:MGI:4867584|PMID:21113149
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	EPHB2	IMP		Human	PMID:24803541
Biological Process	GO:0097104	postsynaptic membrane assembly	Ephb2	IDA		Rat	PMID:11136979|RGD:13702452
Biological Process	GO:0097104	postsynaptic membrane assembly	Ephb2	IEP		Rat	PMID:11136979|RGD:13702452
Biological Process	GO:0097104	postsynaptic membrane assembly	Ephb2	IMP		Rat	PMID:11136979|RGD:13702452
Biological Process	GO:0006468	protein phosphorylation	Ephb2	IDA		Mouse	PMID:12971893
Biological Process	GO:2000785	regulation of autophagosome assembly	EPHB2	IDA		Human	PMID:33280498
Biological Process	GO:0050770	regulation of axonogenesis	Ephb2	IDA		Mouse	PMID:14988728
Biological Process	GO:2000822	regulation of behavioral fear response	Ephb2	IMP		Rat	PMID:26354908|RGD:127285622
Biological Process	GO:0030193	regulation of blood coagulation	EPHB2	IMP		Human	PMID:30213874
Biological Process	GO:0050878	regulation of body fluid levels	Ephb2	IMP		Mouse	MGI:MGI:1859095|PMID:10839360
Biological Process	GO:0051489	regulation of filopodium assembly	Ephb2	IMP		Rat	PMID:21364901|RGD:127285794
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity	Ephb2	IMP	MGI:MGI:2149765	Mouse	PMID:11754835
Biological Process	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	Ephb2	IDA		Rat	PMID:33722292|RGD:127285641
Biological Process	GO:0051963	regulation of synapse assembly	Ephb2	IDA		Mouse	PMID:17122040
Biological Process	GO:0051963	regulation of synapse assembly	Ephb2	IMP		Mouse	PMID:17122040
Biological Process	GO:0051963	regulation of synapse assembly	Ephb2	EXP		Mouse	PMID:17122040
Biological Process	GO:2000316	regulation of T-helper 17 type immune response	Ephb2	IDA		Rat	PMID:33722292|RGD:127285641
Biological Process	GO:0031290	retinal ganglion cell axon guidance	Ephb2	IDA		Mouse	PMID:12971893
Biological Process	GO:0060021	roof of mouth development	Ephb2	IMP		Mouse	MGI:MGI:84499|PMID:8947026
Biological Process	GO:0120192	tight junction assembly	Ephb2	IDA		Rat	PMID:33722292|RGD:127285641
Biological Process	GO:0099557	trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission	Ephb2	IMP		Mouse	MGI:MGI:5819355|PMID:12052960
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Ephb2	IDA		Mouse	PMID:14988728
Biological Process	GO:0001655	urogenital system development	Ephb2	IMP		Mouse	MGI:MGI:3047196|PMID:15223334
Biological Process	GO:0110077	vesicle-mediated intercellular transport	Ephb2	IDA		Rat	PMID:33722292|RGD:127285641

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern