Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EPHB4
  • Mouse genes Ephb4
  • Rat genes Ephb4
  • Zfish genes ephb4a,ephb4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ephb4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005003	ephrin receptor activity	EPHB4	IDA		Human	PMID:12734395
Molecular Function	GO:0005003	ephrin receptor activity	EPHB4	IDA		Human	PMID:15930280
Molecular Function	GO:0005515	protein binding	EPHB4	IPI	UniProtKB:P52799	Human	PMID:16867992
Molecular Function	GO:0005515	protein binding	EPHB4	IPI	UniProtKB:P01588	Human	PMID:26481148
Molecular Function	GO:0005515	protein binding	EPHB4	IPI	UniProtKB:P52799	Human	PMID:26481148
Molecular Function	GO:0005515	protein binding	EPHB4	IPI	UniProtKB:P52799	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	EPHB4	IPI	UniProtKB:P20936	Human	PMID:30578106
Molecular Function	GO:0005515	protein binding	EPHB4	IPI	UniProtKB:P52799	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	EPHB4	IPI	UniProtKB:P54756	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	EPHB4	IPI	UniProtKB:Q15375	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	EPHB4	IPI	UniProtKB:Q9UF33	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	Ephb4	IPI	PR:P54763	Mouse	PMID:12971893
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	EPHB4	IDA		Human	PMID:8188704
Cellular Component	GO:0070062	extracellular exosome	EPHB4	HDA		Human	PMID:23533145
Cellular Component	GO:0005886	plasma membrane	EPHB4	IDA		Human	PMID:8188704
Biological Process	GO:0035475	angioblast cell migration involved in selective angioblast sprouting	ephb4a	IMP	ZFIN:ZDB-MRPHLNO-070702-1	Zfish	PMID:19815777
Biological Process	GO:0001525	angiogenesis	Ephb4	IMP		Mouse	MGI:MGI:1345938|PMID:10518221
Biological Process	GO:0001568	blood vessel development	ephb4a	IGI	ZFIN:ZDB-GENE-030131-4694	Zfish	PMID:24837431
Biological Process	GO:0001568	blood vessel development	ephb4a	IMP	ZFIN:ZDB-MRPHLNO-140709-1	Zfish	PMID:24837431
Biological Process	GO:0001568	blood vessel development	ephb4a	IGI	ZFIN:ZDB-GENE-070713-2	Zfish	PMID:24837431
Biological Process	GO:0001568	blood vessel development	ephb4a	IMP	ZFIN:ZDB-MRPHLNO-140709-2	Zfish	PMID:24837431
Biological Process	GO:0007155	cell adhesion	EPHB4	IDA		Human	PMID:12734395
Biological Process	GO:0002042	cell migration involved in sprouting angiogenesis	EPHB4	IDA		Human	PMID:12734395
Biological Process	GO:0060026	convergent extension	ephb4a	IGI	ZFIN:ZDB-MRPHLNO-070702-1,ZFIN:ZDB-MRPHLNO-070713-1	Zfish	PMID:17412835
Biological Process	GO:0048013	ephrin receptor signaling pathway	EPHB4	IDA		Human	PMID:12734395
Biological Process	GO:0048013	ephrin receptor signaling pathway	Ephb4	IGI		Mouse	MGI:MGI:1345938|PMID:10518221
Biological Process	GO:0048013	ephrin receptor signaling pathway	ephb4a	IGI	ZFIN:ZDB-GENE-030131-4694	Zfish	PMID:24837431
Biological Process	GO:0003007	heart morphogenesis	Ephb4	IMP		Mouse	MGI:MGI:1345938|PMID:10518221
Biological Process	GO:0070121	Kupffer's vesicle development	ephb4b	IMP	ZFIN:ZDB-GENO-161213-2	Zfish	PMID:27287807
Biological Process	GO:0070121	Kupffer's vesicle development	ephb4b	IMP	ZFIN:ZDB-MRPHLNO-161004-2	Zfish	PMID:27287807
Biological Process	GO:0001945	lymph vessel development	ephb4a	IMP	ZFIN:ZDB-MRPHLNO-181204-1	Zfish	PMID:29905864
Biological Process	GO:0001945	lymph vessel development	ephb4a	IMP	ZFIN:ZDB-MRPHLNO-140709-1	Zfish	PMID:29905864
Biological Process	GO:1903849	positive regulation of aorta morphogenesis	Ephb4	IMP	MGI:MGI:2183162	Mouse	PMID:18952909
Biological Process	GO:2000525	positive regulation of T cell costimulation	Ephb4	IGI	MGI:MGI:1096338	Mouse	PMID:15599401
Biological Process	GO:0046777	protein autophosphorylation	EPHB4	IDA		Human	PMID:8188704
Biological Process	GO:0001756	somitogenesis	ephb4b	IMP		Zfish	PMID:9765210|ZFIN:ZDB-PUB-981105-1
Biological Process	GO:0048845	venous blood vessel morphogenesis	Ephb4	IMP	MGI:MGI:2183162	Mouse	PMID:18952909
Biological Process	GO:0048845	venous blood vessel morphogenesis	ephb4a	IMP	ZFIN:ZDB-MRPHLNO-140709-2	Zfish	PMID:29444212

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern