Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EPHX2
  • Mouse genes Ephx2
  • Rat genes Ephx2
  • Zfish genes ephx2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ephx2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004301	epoxide hydrolase activity	EPHX2	IDA		Human	PMID:10862610
Molecular Function	GO:0004301	epoxide hydrolase activity	EPHX2	IDA		Human	PMID:21217101
Molecular Function	GO:0004301	epoxide hydrolase activity	EPHX2	IDA		Human	PMID:22798687
Molecular Function	GO:0004301	epoxide hydrolase activity	EPHX2	IDA		Human	PMID:8342951
Molecular Function	GO:0004301	epoxide hydrolase activity	Ephx2	IMP		Mouse	MGI:MGI:4947022|PMID:21217101
Molecular Function	GO:0004301	epoxide hydrolase activity	Ephx2	IDA		Rat	PMID:21217101|RGD:21201254
Molecular Function	GO:0004301	epoxide hydrolase activity	Ephx2	IDA		Rat	PMID:8349641|RGD:728835
Molecular Function	GO:0004301	epoxide hydrolase activity	ephx2	IDA		Zfish	PMID:22665795
Molecular Function	GO:0042577	lipid phosphatase activity	EPHX2	IDA		Human	PMID:12574510
Molecular Function	GO:0052642	lysophosphatidic acid phosphatase activity	EPHX2	IDA		Human	PMID:22217705
Molecular Function	GO:0052642	lysophosphatidic acid phosphatase activity	EPHX2	IDA		Human	PMID:22387545
Molecular Function	GO:0000287	magnesium ion binding	EPHX2	IDA		Human	PMID:12574510
Molecular Function	GO:0000287	magnesium ion binding	Ephx2	IMP		Rat	PMID:12574508|RGD:1581955
Molecular Function	GO:0016791	phosphatase activity	EPHX2	IDA		Human	PMID:12574508
Molecular Function	GO:0016791	phosphatase activity	EPHX2	IDA		Human	PMID:15196990
Molecular Function	GO:0016791	phosphatase activity	Ephx2	IDA		Rat	PMID:12574508|RGD:1581955
Molecular Function	GO:0042803	protein homodimerization activity	EPHX2	IDA		Human	PMID:15096040
Molecular Function	GO:0042803	protein homodimerization activity	EPHX2	IDA		Human	PMID:18513744
Molecular Function	GO:0015643	toxic substance binding	EPHX2	IDA		Human	PMID:15096040
Cellular Component	GO:0005829	cytosol	EPHX2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	EPHX2	IDA		Human	PMID:16314446
Cellular Component	GO:0005829	cytosol	EPHX2	IDA		Human	PMID:18513744
Cellular Component	GO:0005829	cytosol	EPHX2	IDA		Human	PMID:8342951
Cellular Component	GO:0005829	cytosol	Ephx2	IDA		Rat	PMID:10445750|RGD:1581957
Cellular Component	GO:0070062	extracellular exosome	EPHX2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	EPHX2	HDA		Human	PMID:23533145
Cellular Component	GO:0005777	peroxisome	EPHX2	IDA		Human	PMID:16314446
Cellular Component	GO:0005777	peroxisome	EPHX2	IDA		Human	PMID:18513744
Cellular Component	GO:0005777	peroxisome	Ephx2	IDA		Rat	PMID:3181162|RGD:1581960
Biological Process	GO:0042632	cholesterol homeostasis	EPHX2	IDA		Human	PMID:18974052
Biological Process	GO:0042632	cholesterol homeostasis	Ephx2	IDA		Mouse	MGI:MGI:3829349|PMID:18974052
Biological Process	GO:0016311	dephosphorylation	EPHX2	IDA		Human	PMID:12574508
Biological Process	GO:0016311	dephosphorylation	EPHX2	IDA		Human	PMID:22217705
Biological Process	GO:0097176	epoxide metabolic process	EPHX2	IDA		Human	PMID:21217101
Biological Process	GO:0097176	epoxide metabolic process	EPHX2	IDA		Human	PMID:22798687
Biological Process	GO:0097176	epoxide metabolic process	Ephx2	IMP		Mouse	MGI:MGI:4947022|PMID:21217101
Biological Process	GO:0097176	epoxide metabolic process	Ephx2	IDA		Rat	PMID:21217101|RGD:21201254
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	ephx2	IMP	ZFIN:ZDB-MRPHLNO-120718-1	Zfish	PMID:22665795
Biological Process	GO:0006954	inflammatory response	Ephx2	IMP		Rat	PMID:15684051|RGD:1581952
Biological Process	GO:0043651	linoleic acid metabolic process	Ephx2	IMP		Rat	PMID:16962614|RGD:5688387
Biological Process	GO:0046839	phospholipid dephosphorylation	EPHX2	IDA		Human	PMID:12574510
Biological Process	GO:0045777	positive regulation of blood pressure	Ephx2	IMP		Rat	PMID:11882632|RGD:728682
Biological Process	GO:0010628	positive regulation of gene expression	EPHX2	IDA		Human	PMID:18974052
Biological Process	GO:0010628	positive regulation of gene expression	Ephx2	IDA		Mouse	MGI:MGI:3829349|PMID:18974052
Biological Process	GO:0002539	prostaglandin production involved in inflammatory response	Ephx2	IMP		Rat	PMID:16962614|RGD:5688387
Biological Process	GO:0090181	regulation of cholesterol metabolic process	EPHX2	IMP		Human	PMID:18974052
Biological Process	GO:0090181	regulation of cholesterol metabolic process	Ephx2	IMP		Mouse	MGI:MGI:3829349|PMID:18974052
Biological Process	GO:0019233	sensory perception of pain	Ephx2	IMP		Rat	PMID:16962614|RGD:5688387
Biological Process	GO:0046272	stilbene catabolic process	EPHX2	IDA		Human	PMID:8342951
Biological Process	GO:0060841	venous blood vessel development	ephx2	IMP	ZFIN:ZDB-MRPHLNO-120718-1	Zfish	PMID:22665795
Biological Process	GO:0060841	venous blood vessel development	ephx2	IMP	ZFIN:ZDB-MRPHLNO-120718-2	Zfish	PMID:22665795

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern