Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EPPK1
  • Mouse genes Eppk1
  • Rat genes
  • Zfish genes eppk1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eppk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019215	intermediate filament binding	EPPK1	IPI	UniProtKB:P02533|UniProtKB:P02533,UniProtKB:P13647|UniProtKB:P05783,UniProtKB:P05787|UniProtKB:P08670	Human	PMID:15671067
Molecular Function	GO:0019215	intermediate filament binding	EPPK1	IPI	UniProtKB:P04264|UniProtKB:P08670|UniProtKB:P17661	Human	PMID:16923132
Molecular Function	GO:1990254	keratin filament binding	Eppk1	IPI	UniProtKB:P05784|UniProtKB:P11679	Mouse	MGI:MGI:5805359|PMID:25617501
Molecular Function	GO:1990254	keratin filament binding	Eppk1	IPI	UniProtKB:Q61781|UniProtKB:Q922U2	Mouse	MGI:MGI:3805230|PMID:18285451
Molecular Function	GO:0005515	protein binding	EPPK1	IPI	UniProtKB:P42566	Human	PMID:35044719
Molecular Function	GO:0003723	RNA binding	EPPK1	HDA		Human	PMID:22681889
Cellular Component	GO:0016327	apicolateral plasma membrane	Eppk1	IDA		Mouse	MGI:MGI:5635761|PMID:25232867
Cellular Component	GO:0045178	basal part of cell	Eppk1	IDA		Mouse	MGI:MGI:5604998|PMID:23599337
Cellular Component	GO:0005923	bicellular tight junction	EPPK1	IDA		Human	PMID:23398049
Cellular Component	GO:0071944	cell periphery	EPPK1	IDA		Human	PMID:23398049
Cellular Component	GO:0005911	cell-cell junction	Eppk1	IDA		Mouse	MGI:MGI:5604998|PMID:23599337
Cellular Component	GO:0005737	cytoplasm	Eppk1	IDA		Mouse	MGI:MGI:5816446|PMID:20926261
Cellular Component	GO:0005737	cytoplasm	Eppk1	IDA		Mouse	PMID:12791695
Cellular Component	GO:0005856	cytoskeleton	EPPK1	IDA		Human	PMID:15671067
Cellular Component	GO:0005856	cytoskeleton	Eppk1	IDA		Mouse	MGI:MGI:5805359|PMID:25617501
Cellular Component	GO:0030056	hemidesmosome	EPPK1	IDA		Human	PMID:23398049
Cellular Component	GO:0045111	intermediate filament cytoskeleton	EPPK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045095	keratin filament	EPPK1	IDA		Human	PMID:23398049
Cellular Component	GO:0045095	keratin filament	Eppk1	IDA		Mouse	MGI:MGI:5816446|PMID:20926261
Cellular Component	GO:0045095	keratin filament	Eppk1	IDA		Mouse	MGI:MGI:3805230|PMID:18285451
Cellular Component	GO:0097356	perinucleolar compartment	EPPK1	IDA		Human	PMID:15671067
Biological Process	GO:0007010	cytoskeleton organization	Eppk1	IMP		Mouse	MGI:MGI:5604998|PMID:23599337
Biological Process	GO:0045110	intermediate filament bundle assembly	Eppk1	IMP		Mouse	MGI:MGI:5816446|PMID:20926261
Biological Process	GO:0045109	intermediate filament organization	EPPK1	IMP		Human	PMID:15671067
Biological Process	GO:0045109	intermediate filament organization	EPPK1	IDA		Human	PMID:23398049
Biological Process	GO:0045109	intermediate filament organization	Eppk1	IDA		Mouse	MGI:MGI:5805359|PMID:25617501
Biological Process	GO:0045109	intermediate filament organization	Eppk1	IMP		Mouse	MGI:MGI:3805230|PMID:18285451
Biological Process	GO:0030336	negative regulation of cell migration	EPPK1	IMP		Human	PMID:23398049
Biological Process	GO:0030336	negative regulation of cell migration	EPPK1	IMP		Human	PMID:27206504
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	EPPK1	IMP		Human	PMID:27206504
Biological Process	GO:0051548	negative regulation of keratinocyte migration	Eppk1	IMP		Mouse	MGI:MGI:3830169|PMID:16382146
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	Eppk1	IMP		Mouse	MGI:MGI:3830169|PMID:16382146
Biological Process	GO:0061045	negative regulation of wound healing	EPPK1	IMP		Human	PMID:23398049
Biological Process	GO:0061045	negative regulation of wound healing	Eppk1	IMP		Mouse	MGI:MGI:5816446|PMID:20926261
Biological Process	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing	Eppk1	IMP		Mouse	MGI:MGI:5604998|PMID:23599337
Biological Process	GO:0030856	regulation of epithelial cell differentiation	Eppk1	IMP		Mouse	MGI:MGI:5604998|PMID:23599337
Biological Process	GO:1905041	regulation of epithelium regeneration	Eppk1	IMP		Mouse	MGI:MGI:3830169|PMID:16382146
Biological Process	GO:0042060	wound healing	EPPK1	IMP		Human	PMID:27206504

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern