Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EPS15
  • Mouse genes Eps15
  • Rat genes Eps15
  • Zfish genes eps15
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eps15

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045296	cadherin binding	EPS15	HDA		Human	PMID:25468996
Molecular Function	GO:0042802	identical protein binding	Eps15	IPI	UniProtKB:P42567	Mouse	MGI:MGI:5508598|PMID:18154663
Molecular Function	GO:0031593	polyubiquitin modification-dependent protein binding	EPS15	IDA		Human	PMID:24768539
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q15811	Human	PMID:10064583
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q9R0X4	Human	PMID:10383425
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:P52594	Human	PMID:10613896
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q9UMX0	Human	PMID:16159959
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q9P0V3	Human	PMID:16325581
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q9UMX0	Human	PMID:17082820
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q9UHD9	Human	PMID:18199683
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q9UMX0	Human	PMID:18199683
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q8WXE9	Human	PMID:18200045
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q9Y6I3	Human	PMID:18200045
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:P63010	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q0JRZ9	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q8WXE9	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q3UQN2	Human	PMID:20448150
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q0JRZ9	Human	PMID:21762413
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:P98082	Human	PMID:22648170
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:P49757	Human	PMID:23211419
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q9QZS3-1	Human	PMID:23211419
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q9QZS3-2	Human	PMID:23211419
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:P57737	Human	PMID:24768539
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q13492	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q9BQI5	Human	PMID:26822536
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q15811	Human	PMID:32203420
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:P49757	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:P52594	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:P58107	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:P63010	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:P98082	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q13492	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q8WXE9	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q9P0V3	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q9UHD9	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q9UMX0	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	EPS15	IPI	UniProtKB:Q9Y6I3	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Eps15	IPI	UniProtKB:Q60902	Mouse	MGI:MGI:3687718|PMID:9446614
Molecular Function	GO:0005515	protein binding	Eps15	IPI	UniProtKB:Q9UMX0	Mouse	MGI:MGI:5634891|PMID:16159959
Molecular Function	GO:0005515	protein binding	Eps15	IPI	UniProtKB:Q8NFH8	Mouse	MGI:MGI:5508598|PMID:18154663
Molecular Function	GO:0005515	protein binding	Eps15	IPI	UniProtKB:P98078	Mouse	MGI:MGI:5448497|PMID:22648170
Molecular Function	GO:0005515	protein binding	Eps15	IPI	UniProtKB:Q80U87	Mouse	MGI:MGI:4821940|PMID:16771824
Molecular Function	GO:0005515	protein binding	Eps15	IPI	PR:Q8VD37-6	Mouse	PMID:17626015
Molecular Function	GO:0005515	protein binding	Eps15	IPI	RGD:620183	Rat	PMID:11872741|RGD:727348
Molecular Function	GO:0005515	protein binding	Eps15	IPI	RGD:2690	Rat	PMID:19835873|RGD:9685535
Molecular Function	GO:0005515	protein binding	Eps15	IPI	RGD:1306254	Rat	PMID:9920862|RGD:9685534
Molecular Function	GO:0005515	protein binding	Eps15	IPI	RGD:71015	Rat	PMID:9920862|RGD:9685534
Cellular Component	GO:0016235	aggresome	EPS15	IDA		Human	PMID:16159959
Cellular Component	GO:0030122	AP-2 adaptor complex	Eps15	IDA		Mouse	MGI:MGI:4887327|PMID:17626015
Cellular Component	GO:0016324	apical plasma membrane	Eps15	IDA		Rat	PMID:16625367|RGD:1600758
Cellular Component	GO:0009925	basal plasma membrane	Eps15	IDA		Rat	PMID:16625367|RGD:1600758
Cellular Component	GO:0060170	ciliary membrane	Eps15	IDA		Mouse	PMID:20427320
Cellular Component	GO:0030132	clathrin coat of coated pit	Eps15	IDA		Mouse	PMID:18434600
Cellular Component	GO:0005905	clathrin-coated pit	Eps15	IDA		Mouse	PMID:20427320
Cellular Component	GO:0030136	clathrin-coated vesicle	Eps15	IDA		Mouse	MGI:MGI:4887327|PMID:17626015
Cellular Component	GO:0005829	cytosol	EPS15	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Eps15	IDA		Rat	PMID:11872741|RGD:727348
Cellular Component	GO:0005769	early endosome	Eps15	IDA		Rat	PMID:21832070|RGD:9685531
Cellular Component	GO:0098978	glutamatergic synapse	Eps15	IDA		Rat	PMID:25023288|RGD:13702241
Cellular Component	GO:0098978	glutamatergic synapse	Eps15	IMP		Rat	PMID:25023288|RGD:13702241
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	EPS15	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	EPS15	HDA		Human	PMID:19946888
Cellular Component	GO:0005886	plasma membrane	EPS15	IDA		Human	PMID:15465819
Cellular Component	GO:0005886	plasma membrane	Eps15	IDA		Mouse	MGI:MGI:4887327|PMID:17626015
Cellular Component	GO:0045202	synapse	Eps15	IDA		Rat	PMID:25023288|RGD:13702241
Biological Process	GO:0048268	clathrin coat assembly	EPS15	IDA		Human	PMID:12807910
Biological Process	GO:0032456	endocytic recycling	Eps15	IMP		Rat	PMID:21832070|RGD:9685531
Biological Process	GO:0006895	Golgi to endosome transport	EPS15	IMP		Human	PMID:24768539
Biological Process	GO:0001921	positive regulation of receptor recycling	Eps15	IMP		Rat	PMID:21832070|RGD:9685531
Biological Process	GO:0098884	postsynaptic neurotransmitter receptor internalization	Eps15	IDA		Rat	PMID:25023288|RGD:13702241
Biological Process	GO:0098884	postsynaptic neurotransmitter receptor internalization	Eps15	IEP		Rat	PMID:25023288|RGD:13702241
Biological Process	GO:0098884	postsynaptic neurotransmitter receptor internalization	Eps15	IMP		Rat	PMID:25023288|RGD:13702241
Biological Process	GO:0019065	receptor-mediated endocytosis of virus by host cell	EPS15	IMP		Human	PMID:21047970
Biological Process	GO:0042127	regulation of cell population proliferation	Eps15	IMP		Rat	PMID:21832070|RGD:9685531
Biological Process	GO:0032880	regulation of protein localization	Eps15	IMP		Mouse	PMID:17868307
Biological Process	GO:0046718	viral entry into host cell	EPS15	IMP		Human	PMID:20202662

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern