Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes EPS8L2
  • Mouse genes Eps8l2
  • Rat genes Eps8l2
  • Zfish genes eps8b,eps8l2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Eps8l2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	EPS8L2	IDA		Human	PMID:14565974
Molecular Function	GO:0045296	cadherin binding	EPS8L2	HDA		Human	PMID:25468996
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	EPS8L2	IDA		Human	PMID:14565974
Molecular Function	GO:0005515	protein binding	EPS8L2	IPI	UniProtKB:Q8IZP0	Human	PMID:14565974
Molecular Function	GO:0005515	protein binding	EPS8L2	IPI	UniProtKB:G5E9A7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EPS8L2	IPI	UniProtKB:O60333-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EPS8L2	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EPS8L2	IPI	UniProtKB:P07196	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EPS8L2	IPI	UniProtKB:P07339	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EPS8L2	IPI	UniProtKB:P28799	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	EPS8L2	IPI	UniProtKB:Q7Z699	Human	PMID:32814053
Cellular Component	GO:0005813	centrosome	EPS8L2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	EPS8L2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	EPS8L2	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	EPS8L2	HDA		Human	PMID:19199708
Cellular Component	GO:0070062	extracellular exosome	EPS8L2	HDA		Human	PMID:23533145
Cellular Component	GO:0032991	protein-containing complex	EPS8L2	IDA		Human	PMID:14565974
Cellular Component	GO:0032587	ruffle membrane	EPS8L2	IDA		Human	PMID:14565974
Cellular Component	GO:0032421	stereocilium bundle	Eps8l2	IDA		Mouse	MGI:MGI:5509070|PMID:23918390
Cellular Component	GO:0032426	stereocilium tip	Eps8l2	IDA		Mouse	MGI:MGI:5509070|PMID:23918390
Cellular Component	GO:0031982	vesicle	EPS8L2	HDA		Human	PMID:19190083
Biological Process	GO:1900029	positive regulation of ruffle assembly	EPS8L2	IGI	UniProtKB:Q08509|UniProtKB:Q8R5F8|UniProtKB:Q91WL0|UniProtKB:Q99K30	Human	PMID:14565974
Biological Process	GO:0035023	regulation of Rho protein signal transduction	EPS8L2	IDA		Human	PMID:14565974
Biological Process	GO:0007266	Rho protein signal transduction	EPS8L2	IDA		Human	PMID:14565974
Biological Process	GO:0007605	sensory perception of sound	Eps8l2	IDA		Mouse	MGI:MGI:5509070|PMID:23918390

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern